Results 21 to 30 of about 40,478 (236)

Expression of Telomerase Catalytic Component, Telomerase Reverse Transcriptase, in Human Gastric Carcinomas [PDF]

Japanese Journal of Cancer Research, 1998
Telomerase activity is believed to be crucial for cellular immortality, which is considered to participate in the development of a majority of human cancers. Human telomerase reverse transcriptase (TERT) has recently been identified as a catalytic subunit of telomerase.
Yasui, Wataru, Tahara, Hidetoshi, Tahara, Eiji, Fujimoto, Junya, Nakayama, Jun‐ichi, Ishikawa, Fuyuki, Ide, Toshinori, Tahara, Eiichi   +7 more
openaire   +2 more sources

Expression of Telomerase Activity, Human Telomerase RNA, and Telomerase Reverse Transcriptase in Gastric Adenocarcinomas [PDF]

Modern Pathology, 2003
Telomerase is an RNA-dependent DNA polymerase that synthesizes TTAGGG telomeric DNA onto chromosome ends to compensate for sequence loss during DNA replication. It has been detected in 85-90% of all primary human cancers, implicating that the telomerase seems to be reactivated in tumors and that such activity may play a role in the tumorigenic process.
Jinyoung, Yoo, Sonya Y, Park, Seok Jin, Kang, Byung Kee, Kim, Sang In, Shim, Chang Suk, Kang   +5 more
openaire   +2 more sources

LARP7 family proteins have conserved function in telomerase assembly [PDF]

, 2018
Understanding the intricacies of telomerase regulation is crucial due to the potential health benefits of modifying its activity. Telomerase is composed of an RNA component and reverse transcriptase. However, additional factors required during biogenesis
Alenazi, A, Amelina, H, Armstrong, CA, Collopy, LC, Goncalves, T, Moiseeva, V, Pearson, SR, Pinder, C, Tomita, K, Ware, TL, Yang, Q, Í Kongsstovu, S   +11 more
core   +2 more sources

The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids. [PDF]

, 2015
Telomerase is an enzyme that adds repetitive DNA sequences to the ends of chromosomes and consists of two main subunits: the telomerase reverse transcriptase (TERT) protein and an associated telomerase RNA (TER). The telomerase essential N-terminal (TEN)
Akiyama, Benjamin M, Parks, Joseph W, Stone, Michael D   +2 more
core   +2 more sources

Telomerase Activity Reconstituted in Vitro with Purified Human Telomerase Reverse Transcriptase and Human Telomerase RNA Component [PDF]

Journal of Biological Chemistry, 2000
Telomerase is a specialized reverse transcriptase that catalyzes elongation of the telomeric tandem repeat, TTAGGG, by addition of this sequence to the ends of existing telomeres. Human telomerase reverse transcriptase (hTERT) has been identified as a catalytic enzyme involved in telomere elongation that requires telomerase RNA, human telomerase RNA ...
K, Masutomi, S, Kaneko, N, Hayashi, T, Yamashita, Y, Shirota, K, Kobayashi, S, Murakami   +6 more
openaire   +2 more sources

AZT as a telomerase inhibitor

Frontiers in Oncology, 2012
Telomerase is a highly specialized reverse transcriptase and the maintenance of telomeric length is determined by this specific enzyme. The human holoenzyme telomerase is a ribonucleoprotein composed by a catalytic subunit, hTERT, an RNA component, hTR ...
Daniel E Gomez, Romina G Armando, Daniel F. eAlonso   +2 more
doaj   +1 more source

The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients [PDF]

, 2018
Background: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable.
A Celeghin, A Habr-Gama, AL Appelt, Alessandro Perin, AM Mandard, Angela Buonadonna, Anita De Rossi, Antonino De Paoli, C Alix-Panabières, C Belluco, Caterina Boso, Claudio Belluco, D Beddy, D Hanahan, D Lin, D Tural, E Rampazzo, E Rampazzo, E Rampazzo, EH Blackburn, Elisa Palazzari, Enrica Rampazzo, Francesca Bergamo, G Saretzki, G Spolverato, Giovanna Spiro, I Gingras, J Buijsen, J Maláska, JA March-Villalba, JF Bosset, JM Lewis, JP Gerard, K Bujko, K Kojima, L Moureau-Zabotto, L Terrin, L Terrin, LA Torre, M Maas, M Spornraft, MB Amin, MS Roh, N Miura, N Tani, P Boscolo-Rizzo, Paola Del Bianco, R Bertorelle, R Bertorelle, R Sauer, R Siegel, RK Deblakshmi, Roberta Bertorelle, S Giunco, S Pucciarelli, S Pucciarelli, Salvatore Pucciarelli, Sara Leonardi, SB Edge, SH Lim, SM Lledó, T El-Hefnawy, Y Kang   +62 more
core   +1 more source

Human Papillomavirus E2 Down-regulates the Human Telomerase Reverse Transcriptase Promoter [PDF]

Journal of Biological Chemistry, 2002
The transcriptional regulation of the human telomerase reverse transcriptase (hTERT) gene is a critical step in transformation and differentiation. Human papillomavirus E2 protein inhibits cell growth in HPV-infected cells and triggers apoptosis in HeLa cells.
Lee, D Lee, Daeyoup, Kim, HZ Kim, Hak-Zoo, Jeong, KW Jeong, Kwi Wan, Shim, YS Shim, Young Sam, Horikawa, I Horikawa, Izumi, Barrett, JC Barrett, J. Carl, Choe, J Choe, Joonho   +6 more
openaire   +2 more sources

Structural basis of template-boundary definition in Tetrahymena telomerase. [PDF]

, 2015
Telomerase is required to maintain repetitive G-rich telomeric DNA sequences at chromosome ends. To do so, the telomerase reverse transcriptase (TERT) subunit reiteratively uses a small region of the integral telomerase RNA (TER) as a template.
Akiyama, Ben M, Jansson, Linnea I, Lu, Cheng, Ooms, Alexandra, Rubin, Seth M, Stone, Michael D   +5 more
core   +2 more sources

Investigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitors [PDF]

, 2018
The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/164022/article, DOI : 10.2174/1570163815666180724113208. © 2018 Bentham ScienceA series of 1,3,4-oxadiazole derivatives with significant broad-spectrum anticancer ...
Almerico, Anna Maria, Pecoraro, Beatrice, Tutone, Marco   +2 more
core   +2 more sources