Results 21 to 30 of about 24,740 (216)

Telomerase Activity Reconstituted in Vitro with Purified Human Telomerase Reverse Transcriptase and Human Telomerase RNA Component [PDF]

Journal of Biological Chemistry, 2000
Telomerase is a specialized reverse transcriptase that catalyzes elongation of the telomeric tandem repeat, TTAGGG, by addition of this sequence to the ends of existing telomeres. Human telomerase reverse transcriptase (hTERT) has been identified as a catalytic enzyme involved in telomere elongation that requires telomerase RNA, human telomerase RNA ...
Masutomi, Kenichi, Kaneko, Shuichi, Hayashi, Naoyuki, Yamashita, Tatsuya, Shirota, Yukihiro, Kobayashi, Kenichi, Murakami, Seishi   +6 more
openaire   +3 more sources

In silico Analysis of Human Telomerase Reverse Transcriptase (hTERT ) Gene: Identification of a Distant Homolog of Melanoma Antigen Family Gene (MAGE)

Cancer Informatics, 2009
Melanoma antigen family (MAGE) genes are widely expressed in various tumor types but silent in normal cells except germ-line cells lacking human leukocyte antigen (HLA) expression.
Ruhul Amin, Jesmin, Hasan Jamil, M. Anwar Hossain   +3 more
doaj   +1 more source

Transcriptional regulation of the human telomerase reverse transcriptase [PDF]

Transcription, 2010
hTERT and NFAT were thought until recently to belong to separate metabolic compartments. The involvement of NFAT in the induction of hTERT transcription suggested by hTERT expression variations during lymphocyte stimulation and immunosuppressive treatments explains the link between hTERT expression and cell stimulation and offers new insights for ...
Amel, Chebel, Martine, Ffrench
openaire   +2 more sources

Expression of Telomerase Activity, Human Telomerase RNA, and Telomerase Reverse Transcriptase in Gastric Adenocarcinomas [PDF]

Modern Pathology, 2003
Telomerase is an RNA-dependent DNA polymerase that synthesizes TTAGGG telomeric DNA onto chromosome ends to compensate for sequence loss during DNA replication. It has been detected in 85-90% of all primary human cancers, implicating that the telomerase seems to be reactivated in tumors and that such activity may play a role in the tumorigenic process.
Jinyoung, Yoo, Sonya Y, Park, Seok Jin, Kang, Byung Kee, Kim, Sang In, Shim, Chang Suk, Kang   +5 more
openaire   +2 more sources

Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis

, 2021
Telomeres protect genomic stability and shortening is one of the hallmarks of ageing. Telomerase reverse transcriptase (TERT) is the major protein component of telomerase, which elongates telomeres.
Denham, Joshua, Sellami, Maha
core   +1 more source

Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma

World Journal of Gastroenterology, 2006
To study the activity of telomerase and the expression of human telomerase reverse transcriptase (hTERT) in colorectal carcinoma and its adjacent tissues, normal mucosa and adenomatoid polyp, and to evaluate their relation with carcinogenesis and progression of colorectal carcinoma.Telomerase activity and hTERT expression were determined in 30 samples ...
Jian-Lun, Liu, Lian-Ying, Ge, Gui-Nian, Zhang   +2 more
openaire   +2 more sources

Expression of Telomerase Catalytic Component, Telomerase Reverse Transcriptase, in Human Gastric Carcinomas [PDF]

Japanese Journal of Cancer Research, 1998
Telomerase activity is believed to be crucial for cellular immortality, which is considered to participate in the development of a majority of human cancers. Human telomerase reverse transcriptase (TERT) has recently been identified as a catalytic subunit of telomerase.
Yasui, Wataru, Tahara, Hidetoshi, Tahara, Eiji, Fujimoto, Junya, Nakayama, Jun‐ichi, Ishikawa, Fuyuki, Ide, Toshinori, Tahara, Eiichi   +7 more
openaire   +2 more sources

In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs.

PLoS ONE, 2012
Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular ...
Kyle R Hukezalie, Naresh R Thumati, Hélène C F Côté, Judy M Y Wong   +3 more
doaj   +1 more source

Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. [PDF]

PLoS ONE, 2013
The Hedgehog (HH) signaling pathway is critical for normal embryonic development, tissue patterning and cell differentiation. Aberrant HH signaling is involved in multiple human cancers.
Tapati Mazumdar, Ranjodh Sandhu, Maha Qadan, Jennifer DeVecchio, Victoria Magloire, Akwasi Agyeman, Bibo Li, Janet A Houghton   +7 more
doaj   +1 more source

Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. [PDF]

, 2004
The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear.
Beverley, PCL, Catherine H. Orteu, Peter C.L. Beverley, Graham R. Foster, Jackson, SE, Fletcher, JM, Reed, JR, Maria Vieira D. Soares, Soares, MVD, Salmon, Michael, Katie E. Birch, Orteu, CH, John R. Reed, Mike Salmon, Birch, KE, Milica Vukmanovic-Stejic, Jean M. Fletcher, Arne N. Akbar, Beverley, Peter, Soarees, MV, Akbar, AN, Joanne E. Cook, Soares, MV, Rustin, MH, Cook, JE, Beverley, PC, Foster, GR, Salmon, M, Vukmanovic-Stejic, M, Malcolm H.A. Rustin, Rustin, MHA, Sarah E. Jackson   +31 more
core   +1 more source