Expression of Telomerase Activity, Human Telomerase RNA, and Telomerase Reverse Transcriptase in Gastric Adenocarcinomas [PDF]
Modern Pathology, 2003 Telomerase is an RNA-dependent DNA polymerase that synthesizes TTAGGG telomeric DNA onto chromosome ends to compensate for sequence loss during DNA replication. It has been detected in 85-90% of all primary human cancers, implicating that the telomerase seems to be reactivated in tumors and that such activity may play a role in the tumorigenic process.
Jinyoung, Yoo +5 more
openaire +2 more sources
Prognostic Relevance of hTERT mRNA Expression in Ductal Adenocarcinoma of the Pancreas
Neoplasia: An International Journal for Oncology Research, 2008 Telomerase is thought to play an essential role in tumorigenesis and progression. Its activity is directly correlated with the expression of its catalytic subunit, human telomerase reverse transcriptase (hTERT).
Lukasz-Filip Grochola +7 more
doaj +1 more source
Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. [PDF]
PLoS ONE, 2013 The Hedgehog (HH) signaling pathway is critical for normal embryonic development, tissue patterning and cell differentiation. Aberrant HH signaling is involved in multiple human cancers.
Tapati Mazumdar +7 more
doaj +1 more source
Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma
World Journal of Gastroenterology, 2006 To study the activity of telomerase and the expression of human telomerase reverse transcriptase (hTERT) in colorectal carcinoma and its adjacent tissues, normal mucosa and adenomatoid polyp, and to evaluate their relation with carcinogenesis and progression of colorectal carcinoma.Telomerase activity and hTERT expression were determined in 30 samples ...
Jian-Lun, Liu +2 more
openaire +2 more sources
Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng +10 more
wiley +2 more sources
How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript
Biomedicines, 2022 Telomerase RNA has been uncovered as a component of the telomerase enzyme, which acts as a reverse transcriptase and maintains the length of telomeres in proliferated eukaryotic cells.
Maria Rubtsova, Olga Dontsova
doaj +1 more source
Expression of Telomerase Catalytic Component, Telomerase Reverse Transcriptase, in Human Gastric Carcinomas [PDF]
Japanese Journal of Cancer Research, 1998 Telomerase activity is believed to be crucial for cellular immortality, which is considered to participate in the development of a majority of human cancers. Human telomerase reverse transcriptase (TERT) has recently been identified as a catalytic subunit of telomerase.
Yasui, Wataru +7 more
openaire +2 more sources
The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth
Neoplasia: An International Journal for Oncology Research, 2013 Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies.
Agni Christodoulidou +7 more
doaj +1 more source
An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity
Neoplasia: An International Journal for Oncology Research, 2000 Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence.
Xiaoming Yi +5 more
doaj +1 more source
Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma
World Journal of Gastroenterology, 2004 Most cancer cells acquire immortal capability by telomerase activation. The human telomerase reverse transcriptase gene (hTERT) is considered to be the major determinant of the enzymatic activity of human telomerase, and the hTERT promoter contains several c-Myc binding sites that mediate hTERT transcriptional activation.
Cheng-Jueng, Chen +7 more
openaire +2 more sources