Results 91 to 100 of about 28,516 (233)

Structure of telomerase reverse transcriptase (TERT).

, 2017
TERT contains a long NTE1 linked with a central catalytic RT domain and a short carboxy CTE, (TEN, yellow; TRBD, orange; fingers, gray; RT, blue; CTE, magenta) with conserved motifs in TRBD (T, green; CP, red) or RT motifs (IFD, cyan) or black.
Huy Tran (441825), Zhaowen Zhu (3617351), Warren N. Schmidt (3617348), M. Meleah Mathahs (3617354), Thomas O. Moninger (496889)   +4 more
core   +1 more source

TRIM32 controls timely cell cycle exit in muscular differentiation through downregulation of c‐Myc mRNA

The FEBS Journal, EarlyView.
Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong, Elisa Lazzari, Sabrina Pacor, Simeone Dal Monego, Erica Piovesan, Danilo Licastro, Germana Meroni   +6 more
wiley   +1 more source

Transcriptional regulation of the human telomerase reverse transcriptase [PDF]

Transcription, 2010
hTERT and NFAT were thought until recently to belong to separate metabolic compartments. The involvement of NFAT in the induction of hTERT transcription suggested by hTERT expression variations during lymphocyte stimulation and immunosuppressive treatments explains the link between hTERT expression and cell stimulation and offers new insights for ...
Amel, Chebel, Martine, Ffrench
openaire   +2 more sources

Telomere-independent functions of telomerase in nuclei, cytoplasm and mitochondria

Frontiers in Oncology, 2012
Telomerase canonical activity at telomeres prevents telomere shortening, allowing chromosome stability and cellular proliferation. To perform this task, the catalytic subunit (TERT) of the enzyme works as a reverse transcriptase together with the ...
Ilaria eChiodi, Chiara eMondello
doaj   +1 more source

Mucosal Melanoma of Head and Neck: A Rare and Aggressive Disease—A Register‐Based Cohort Study

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Mucosal melanomas of the head and neck are rare and often diagnosed in the advanced stage. This study examines the incidence, survival and histology of mucosal melanoma compared to its cutaneous counterpart. Methods This register‐based cohort study reviews head and neck melanomas at Helsinki University Hospital, Finland, from 2002 ...
Sara C. Degerholm, Tuula A. Salo, Matti O. Mauramo   +2 more
wiley   +1 more source

Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma

World Journal of Gastroenterology, 2006
To study the activity of telomerase and the expression of human telomerase reverse transcriptase (hTERT) in colorectal carcinoma and its adjacent tissues, normal mucosa and adenomatoid polyp, and to evaluate their relation with carcinogenesis and progression of colorectal carcinoma.Telomerase activity and hTERT expression were determined in 30 samples ...
Jian-Lun, Liu, Lian-Ying, Ge, Gui-Nian, Zhang   +2 more
openaire   +2 more sources

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Immunohistochemical Detection of Telomerase (hTERT) Protein in Human Cancer Tissues and a Subset of Cells in Normal Tissues

Neoplasia: An International Journal for Oncology Research, 2001
We examined human telomerase reverse transcriptase (hTERT) protein distribution by immunohistochemistry in cultured cells and tissue sections. Cells with telomerase activity had nuclear positive signals whereas cells without telomerase activity did not ...
Eiso Hiyama, Keiko Hiyama, Takashi Yokoyama, Jerry W. Shay   +3 more
doaj   +1 more source

Highly Polygenic Control of Photosynthetic Responses to Nighttime Temperature Studied by Genomic Prediction

Plant, Cell &Environment, EarlyView.
ABSTRACT Rising nighttime temperature (Tnight) can reduce crop yields while low Tnight may restrict plant growth and development. Despite quantifiable effects of Tnight, genetic basis underlying plant responses to Tnight remains unclear. We investigated natural variation in long‐term response of effective photosynthetic efficiency (Fq’/Fm’) to Tnight ...
Ana Carolina dos Santos Sá, Alina Bazarova, Andreas Fischbach, Stefan Kesselheim, Benjamin Stich, Shizue Matsubara   +5 more
wiley   +1 more source

Messenger RNA From Canine Cytology Lymph Node Specimens Can Be Utilised for Gene Expression Profiling Using Digital RNA Counting

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Gene expression profiling (GEP) is being used with increasing frequency to characterise canine tumours, but canine samples are often not collected in a medium to preserve RNA. Cytology samples from human tumours have been shown to provide adequate RNA for GEP using NanoString nCounter technology, suggesting a similar approach might be viable ...
McKenzie Olsen, Emily Rout, Kelly Hughes, Janna Yoshimoto, Anne Avery, R. Adam Harris   +5 more
wiley   +1 more source