The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth
Neoplasia: An International Journal for Oncology Research, 2013 Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies.
Agni Christodoulidou +7 more
doaj +1 more source
Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia [PDF]
, 2017 Telomeres are protective repeats of TTAGGG sequences located at the end of human chromosomes. They are essential to maintain chromosomal integrity and genome stability.
Bezares, Raimundo F. +6 more
core +1 more source
Relationship between hTERT levels and oxidative stress in epilepsy patients
Epilepsia Open, EarlyView.Abstract Objective Human telomerase reverse transcriptase (hTERT) is a key determinant of telomere maintenance and cellular aging. Oxidative stress plays a role in neurodegenerative processes by causing cellular damage through increased reactive oxygen species.
Muhammed Mehdi Üremiş +3 more
wiley +1 more source
Nature CommunicationsIn most eukaryotes, the reverse transcriptase telomerase counteracts telomere shortening by processively adding telomeric DNA repeat sequences to chromosome ends.
Sebastian Balch +5 more
doaj +1 more source
The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo [PDF]
PeerJ, 2016 Telomerase core enzyme minimally consists of the telomerase reverse transcriptase domain-containing protein (Est2 in budding yeast S. cerevisiae) and telomerase RNA, which contains the template specifying the telomeric repeat sequence synthesized.
Tet Matsuguchi, Elizabeth Blackburn
doaj +2 more sources
The correlation between telomerase activity and BaX/BcL-2 ratio in valproic acid-treated MCF-7 breast cancer cell line [PDF]
, 2015 Objective(s): Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms.
Asadi, J., Gharaei, R., Vafaiyan, Z.
core +2 more sources
Advanced Genetics, Volume 6, Issue 1, March 2025.This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley +1 more source
Telomerase: An exploration toward the end of cancer
Indian Journal of Dental Research, 2017 Background: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells.
Deepika Bablani Popli +2 more
doaj +1 more source
The T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase wild-type A case report
Acta Radiologica Open, 2023 We present a case of the T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase (IDH )-wild type. The T2-FLAIR mismatch sign is known as a highly specific imaging finding of astrocytoma, IDH -mutant.
Shunsuke Nishimura +7 more
doaj +1 more source
Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells [PDF]
, 2017 Aberrant activation of telomerase occurs in 85-90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal.
Hiyama K +4 more
core +1 more source