Results 21 to 30 of about 24,987 (188)

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo [PDF]

Current Biology, 2000
Mammalian telomerase is essential for the maintenance of telomere length [1–5]. Its catalytic core comprises a reverse transcriptase component (TERT) and an RNA component. While the biochemical role of mammalian TERT is well established [6–11], it is unknown whether it is sufficient for telomere-length maintenance, chromosome stability or other ...
Liu, Y, Snow, B.E, Hande, M.P, Yeung, D, Erdmann, N.J, Wakeham, A, Itie, A, Siderovski, D.P, Lansdorp, P.M, Robinson, M.O, Harrington, L   +10 more
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QSAR, pharmacophore modeling and molecular docking studies to identify structural alerts for some nitrogen heterocycles as dual inhibitor of telomerase reverse transcriptase and human telomeric G-quadruplex DNA

Future Journal of Pharmaceutical Sciences, 2021
Background Telomerase reverse transcriptase (TERT) and human telomeric G-quadruplex DNA are amongst the favorable target for researchers to discover novel and more effective anticancer agents.
R. D. Jawarkar, R. L. Bakal, P. N. Khatale, Israa Lewaa, Chetan M. Jain, Jagdish V. Manwar, Minal S. Jaiswal   +6 more
doaj   +1 more source

Regulation of the human telomerase reverse transcriptase gene [PDF]

Oncogene, 2002
Most somatic human cells lack telomerase activity because they do not express the telomerase reverse transcriptase (hTERT) gene. Conversely, most cancer cells express hTERT and are telomerase positive. For most tumors it is not clear whether hTERT expression is due to their origin from telomerase positive stem cells or to reactivation of the gene ...
Ducrest, A. L., Szutorisz, H., Lingner, J., Nabholz, M.   +3 more
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RNA Binding Domain of Telomerase Reverse Transcriptase [PDF]

Molecular and Cellular Biology, 2001
Telomerase is a ribonucleoprotein reverse transcriptase that extends the ends of chromosomes. The two telomerase subunits essential for catalysis in vitro are the telomerase reverse transcriptase (TERT) and the telomerase RNA. Using truncations and site-specific mutations, we identified sequence elements of TERT and telomerase RNA required for ...
Lai, Cary, Mitchell, James R, Collins, Kathleen   +2 more
openaire   +3 more sources

Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. [PDF]

PLoS Genetics, 2011
The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component. During telomere synthesis, telomerase adds multiple short DNA repeats successively, a property known ...
Jonathan K Alder, Joy D Cogan, Andrew F Brown, Collin J Anderson, William E Lawson, Peter M Lansdorp, John A Phillips, James E Loyd, Julian J-L Chen, Mary Armanios   +9 more
doaj   +1 more source

Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast

Nature Communications, 2018
The core of the telomerase holoenzyme is composed of the reverse transcriptase and the non-coding RNA template. Here the authors identify Pof8 as a new constitutive component of fission yeast telomerase, loss of which causes telomerase assembly defects ...
Diego J. Páez-Moscoso, Lili Pan, Rutendo F. Sigauke, Morgan R. Schroeder, Wen Tang, Peter Baumann   +5 more
doaj   +1 more source

Functional Multimerization of the Human Telomerase Reverse Transcriptase [PDF]

Molecular and Cellular Biology, 2001
The telomerase enzyme exists as a large complex (approximately 1,000 kDa) in mammals and at minimum is composed of the telomerase RNA and the catalytic subunit telomerase reverse transcriptase (TERT). In Saccharomyces cerevisiae, telomerase appears to function as an interdependent dimer or multimer in vivo (J. Prescott and E. H.
T L, Beattie, W, Zhou, M O, Robinson, L, Harrington   +3 more
openaire   +2 more sources

Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia

Haematologica, 2012
Background Chronic idiopathic neutropenia is characterized by immune-mediated suppression of neutrophil production. Because patients with immune-mediated bone marrow failure syndromes display age-inappropriate telomere shortening in leukocytes, we ...
Konstantia I. Pavlaki, Maria-Christina Kastrinaki, Michail Klontzas, Maria Velegraki, Irene Mavroudi, Helen A. Papadaki   +5 more
doaj   +1 more source

Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases

Biomedicines, 2021
Telomerase is an enzyme that in its canonical function extends and maintains telomeres, the ends of chromosomes. This reverse transcriptase function is mainly important for dividing cells that shorten their telomeres continuously.
Gabriele Saretzki, Tengfei Wan
doaj   +1 more source

Telomerase and retrotransposons: Reverse transcriptases that shaped genomes [PDF]

Proceedings of the National Academy of Sciences, 2011
“Two independent groups of investigators have found evidence of an enzyme… which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications… information transfer from DNA to RNA can be inverted.” 1970, preamble to refs. 1 and 2.
Marlene, Belfort, M Joan, Curcio, Neal F, Lue   +2 more
openaire   +2 more sources