Results 21 to 30 of about 28,516 (233)

Expression of telomerase reverse transcriptase in adult goldfish retina

Journal of Molecular Neuroscience, 2007
Telomerase, a specialized reverse transcriptase that maintains telomere during cell division, is commonly associated with cell proliferation. Increasing evidence suggests that telomerase may bear functions other than telomere elongation.
Yip, HK, Tsao, GSW, So, KF, Lau, BWM
core   +5 more sources

Human telomerase reverse transcriptase expression in ovarian tumors

Indian Journal of Pathology and Microbiology, 2012
Background : Ovarian cancer is the 6 th most common cancer among women. In ovarian tumors, the borderline category is not well defined due to the difficulty in assessing stromal invasion. The World Health Organization (WHO) defined it as tumor that lacks
Awadh Ali Makhashen Maraei, Ahmad Zailani Hatta, Mohd Sidik Shiran, Geok Chin Tan   +3 more
doaj   +3 more sources

Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage [PDF]

PeerJ, 2022
Background Angiogenesis is an endogenous repair mechanism following hypoxic-ischemic brain damage (HIBD). Interestingly, recent studies have shown that angiogenesis can be regulated by telomerase reverse transcriptase (TERT), a critical component of ...
Jiao Li, Yi Feng, Jing Zhao, Zhi Fang, Haiting Liu   +4 more
doaj   +2 more sources

Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. [PDF]

Bioorg Med Chem Lett
Expression of telomerase reverse transcriptase (TERT) is a hallmark of cancer, maintaining telomere length and integrity to enable replicative immortality.
Frost GB, Liu Y, Kron SJ, Scheidt KA.
europepmc   +2 more sources

Mitochondrial Telomerase Reverse Transcriptase, a Target for Cardiovascular Disease? [PDF]

Function, 2022
Keiichi Torimoto, Satoru Eguchi
doaj   +2 more sources

The telomerase reverse transcriptase: components and regulation [PDF]

Genes & Development, 1998
The idea that chromosomes have special terminal structures first arose as a consequence of experiments conducted by Muller, who found that treatment of Drosophila with X-rays rarely resulted in terminal deletions or inversions of the chromosomes (Muller 1938).
C I, Nugent, V, Lundblad
openaire   +2 more sources

TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly

Cell Reports, 2023
Summary: Localization of a variety of RNAs to non-membrane-bound cellular compartments such as nucleoli and Cajal bodies is critical for their stability and function.
Basma M. Klump, Gloria I. Perez, Eric M. Patrick, Kate Adams-Boone, Scott B. Cohen, Li Han, Kefei Yu, Jens C. Schmidt   +7 more
doaj   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis

Nature Communications, 2022
Most eukaryotes maintain telomeres using a specialized reverse transcriptase. Here the authors report that Thc1 (Telomerase Holoenzyme Component 1) and Bmc1 (Bin3/MePCE 1) form a complex with Pof8, a constitutive member of telomerase in fission yeast.
Diego J. Páez-Moscoso, David V. Ho, Lili Pan, Katie Hildebrand, Kristi L. Jensen, Michaella J. Levy, Laurence Florens, Peter Baumann   +7 more
doaj   +1 more source

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo [PDF]

Current Biology, 2000
Mammalian telomerase is essential for the maintenance of telomere length [1–5]. Its catalytic core comprises a reverse transcriptase component (TERT) and an RNA component. While the biochemical role of mammalian TERT is well established [6–11], it is unknown whether it is sufficient for telomere-length maintenance, chromosome stability or other ...
Liu, Y, Snow, B.E, Hande, M.P, Yeung, D, Erdmann, N.J, Wakeham, A, Itie, A, Siderovski, D.P, Lansdorp, P.M, Robinson, M.O, Harrington, L   +10 more
openaire   +2 more sources