Results 21 to 30 of about 570,627 (165)

Telomeres in Evolution and Development from Biosemiotic Perspective [PDF]

, 2007
Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
core   +1 more source

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

Nature Communications, 2020
Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for ...
Mami Yasukawa, Yoshinari Ando, Taro Yamashita, Yoko Matsuda, Shisako Shoji, Masaki Suimye Morioka, Hideya Kawaji, Kumiko Shiozawa, Mitsuhiro Machitani, Takaya Abe, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Yasuhide Furuta, Tadashi Kondo, Mikako Shirouzu, Yoshihide Hayashizaki, Shuichi Kaneko, Kenkichi Masutomi   +18 more
doaj   +1 more source

In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs.

PLoS ONE, 2012
Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular ...
Kyle R Hukezalie, Naresh R Thumati, Hélène C F Côté, Judy M Y Wong   +3 more
doaj   +1 more source

Insertion of retrotransposons at chromosome ends: adaptive response to chromosome maintenance

Frontiers in Genetics, 2016
The telomerase complex is a specialized reverse transcriptase that inserts tandem DNA arrays at the linear chromosome ends and contributes to the protection of the genetic information in eukaryotic genomes.
Geraldine eServant, Prescott L Deininger
doaj   +1 more source

Telomerase Reverse Transcriptase Regulates microRNAs

International Journal of Molecular Sciences, 2015
MicroRNAs are small non-coding RNAs that inhibit the translation of target mRNAs. In humans, most microRNAs are transcribed by RNA polymerase II as long primary transcripts and processed by sequential cleavage of the two RNase III enzymes, DROSHA and DICER, into precursor and mature microRNAs, respectively.
Lassmann, Timo, Maida, Yoshiko, Tomaru, Yasuhiro, Yasukawa, Mami, Ando, Yoshinari, Kojima, Miki, Kasim, Vivi, Simon, Christophe, Daub, Carsten, Carninci, Piero, Hayashizaki, Yoshihide, Masutomi, Kenkichi   +11 more
openaire   +2 more sources

A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.

PLoS Biology, 2019
Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells.
Wilnelly Hernandez-Sanchez, Wei Huang, Brian Plucinsky, Nelson Garcia-Vazquez, Nathaniel J Robinson, William P Schiemann, Anthony J Berdis, Emmanuel Skordalakes, Derek J Taylor   +8 more
doaj   +1 more source

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo [PDF]

Current Biology, 2000
Mammalian telomerase is essential for the maintenance of telomere length [1–5]. Its catalytic core comprises a reverse transcriptase component (TERT) and an RNA component. While the biochemical role of mammalian TERT is well established [6–11], it is unknown whether it is sufficient for telomere-length maintenance, chromosome stability or other ...
Liu, Y, Snow, B.E, Hande, M.P, Yeung, D, Erdmann, N.J, Wakeham, A, Itie, A, Siderovski, D.P, Lansdorp, P.M, Robinson, M.O, Harrington, L   +10 more
openaire   +2 more sources

Structural studies of three enzymes: telomerase, the methyltransferase CobJ and pectate lyase [PDF]

, 2011
PhDThis thesis investigates the structure and function of three enzymes of biotechnological and biomedical interest: telomerase from Caenorhabtidis elegans, pectate lyase from Bacillus subtilis and the methyltransferase CobJ from Rhodobacter capsulatus.
To, Teng Teng
core   +4 more sources

QSAR, pharmacophore modeling and molecular docking studies to identify structural alerts for some nitrogen heterocycles as dual inhibitor of telomerase reverse transcriptase and human telomeric G-quadruplex DNA

Future Journal of Pharmaceutical Sciences, 2021
Background Telomerase reverse transcriptase (TERT) and human telomeric G-quadruplex DNA are amongst the favorable target for researchers to discover novel and more effective anticancer agents.
R. D. Jawarkar, R. L. Bakal, P. N. Khatale, Israa Lewaa, Chetan M. Jain, Jagdish V. Manwar, Minal S. Jaiswal   +6 more
doaj   +1 more source

Regulation of the human telomerase reverse transcriptase gene [PDF]

Oncogene, 2002
Most somatic human cells lack telomerase activity because they do not express the telomerase reverse transcriptase (hTERT) gene. Conversely, most cancer cells express hTERT and are telomerase positive. For most tumors it is not clear whether hTERT expression is due to their origin from telomerase positive stem cells or to reactivation of the gene ...
Ducrest, A. L., Szutorisz, H., Lingner, J., Nabholz, M.   +3 more
openaire   +2 more sources