Results 1 to 10 of about 5,368 (169)

Study on relationship between genetic abnormalities and clinicopathological features in K hospital's patients with colorectal cancer

Journal of Advanced Biotechnology and Experimental Therapeutics, 2022
The MAPK-ERK, as well as PI3K-AKT signaling transduction pathway, represents a pivotal function in tumorigenesis. Genetic alterations of potential tumor-driven genes, for instance, KRAS, BRAF, NRAS, and PIK3CA can result in uncontrolled cell ...
Linh Dieu Vuong, Ha Hoang Chu, Quang Ngoc Nguyen   +2 more
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DETECTION OF SOMATIC MUTATIONS IN THE BRAF GENE BY PYROSEQUENCING

Сибирский онкологический журнал, 2021
Introduction. Detection of somatic mutations in the BRAF gene can be used in clinical oncology to clarify the diagnosis, select therapy and assess the prognosis of the disease.
O. P. Dribnokhodova, E. A. Dunaeva, G. V. Leshkina, E. A. Yarygina, A. Yu. Bukharina, Ya. A. Voiciehovskaya, E. V. Borisova, S. K. Bormotova, A. I. Daoud, V. N. Khlavich, K. O. Mironov   +10 more
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Deep and lasting response and acquired resistance to BRAFV600E targeting in a low-grade ovarian cancer patient

Cancer Biology & Therapy, 2023
The treatment of BRAFV600E mutant melanoma has been revolutionized by BRAF inhibitors. Furthermore, the BRAF/MEK combination has shown further improvement in clinical outcomes in advanced and in adjuvant melanoma patients.
Sandro Anchisi, Anita Wolfer, Bettina Bisig, Edoardo Missiglia, Amine Tiab, Ehab Mohamed Kamel, Olivier Michielin, George Coukos, Krisztian Homicsko   +8 more
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KRAS and BRAF Concomitant Mutations in a Patient with Metastatic Colon Adenocarcinoma: An Interesting Case Report

Case Reports in Oncology, 2020
A 68-year-old female patient with tenesmus and blood in the stool was admitted to the S.G. Moscati Hospital of Taranto. Investigations revealed infiltrative mucinous colon adenocarcinoma accompanied by lymph node metastases.
Concetta Cafiero, Agnese Re, Gerardo D’Amato, Pier Luigi Surico, Giammarco Surico, Michele Pirrelli, Salvatore Pisconti   +6 more
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Evaluation of mutations in KRAS and BRAF genes in Iranian population with diffuse gastric cancer [PDF]

World Cancer Research Journal, 2019
OBJECTIVE: RAS proteins control signaling pathways which are the main regulators of the normal cell growth and malignant transformation cells. The point mutations in the KRAS gene are current event in numerous human cancers including pancreatic, lung ...
M. Saneipour, A. Moridnia
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Somatic mutations in colorectal cancer: regional experience

Consilium Medicum, 2022
Introduction. Colorectal cancer is one of the most common malignant neoplasms in economically developed countries, ranking 3rd and 2nd in the structure of morbidity and mortality, respectively. Current knowledge about the molecular features of colorectal
Nikolai A. Ognerubov, Elena N. Ezhova
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REQUIREMENTS FOR EFFICIENT PCR CLAMPING BY LOCKED NUCLEIC ACID OLIGONUCLEOTIES FOR SIMPLE AND SENSITIVE DETECTION OF SOMATIC MUTATIONS

Сибирский онкологический журнал, 2018
PCR clamping/wild-type blocking PCR with non-extendable locked nucleic acid (LNA) oligonucleotides is used for sensitive detection of somatic mutations in tumors.
V. A. Shamanin, I. V. Karpov, E. E. Pisareva, N. I. Gutkina, S. P. Kovalenko   +4 more
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Prognostic value of somatic mutation testing and different methods of treatment of low-risk differentiated thyroid cancer [PDF]

Эндокринная хирургия, 2019
Background: Using molecular testing for prediction the course of the disease could possibly help doctors in making therapeutic decisions about the management of patients, because it remains controversial issues in low-risk differentiated thyroid cancer ...
Vera A. Kachko, Vladimir E. Vanushko, Nadezhda M. Platonova   +2 more
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Current Advance in Targeted Treatment and Immunotherapy for BRAF-mutant 
Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2021
With the development of precision medicine, therapies of targeting driver genes have significantly prolonged survival in advanced non-small cell lung cancer (NSCLC) patients.
Na LI, Yanjun XU, Yun FAN
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Ameloblastic Fibrosarcoma of the Jaw: Case Report, Genetic Profiling, and Literature Review

Case Reports in Oncology, 2023
Ameloblastic fibrosarcoma (AFS) is considered a malignant progression resulting from dysplastic changes in an ameloblastic fibroma (AF). Both tumors are extremely rare, with only a few cases reported in the scientific literature.
Duna Barakeh, Afaf Alsolami, Malak Abedalthagafi   +2 more
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