Results 41 to 50 of about 5,368 (169)
Кубанский научный медицинский вестник, 2016 This study identified associations between mutation status of the BRAF gene and the clinico-morphological features of melanoma patients in the South of Russia of the age group over 55 years.
O. I. Kit +5 more
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The Role and Importance of Molecular Tests in Approach to Thyroid Nodules
Turkish Archives of Otorhinolaryngology, 2016 Although there is a significant increase in the detection of thyroid cancer because of the widespread utilization of ultrasound and fine needle aspiration biopsy, sometimes these techniques prove inefficient for diagnosis.
Levent Gürbüzler
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Advanced Science, EarlyView.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source
Development of animal models to study aggressive thyroid cancers
European Thyroid JournalThe development of mouse models for thyroid cancer has significantly advanced over the years, enhancing our understanding of thyroid tumorigenesis, molecular pathways and treatment responses. The earliest mouse models of thyroid cancer relied on hormone,
Shovan Dutta, Jeffrey A Knauf
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Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
KRAS and BRAF mutations in Iranian colorectal cancer patients: A systematic review and meta-analysis
Caspian Journal of Internal Medicine, 2020 Background: Mutations in the EGFR signaling pathway play an important role in the development of colorectal cancer (CRC). Mutations in these genes, like KRAS and BRAF, affect the treatment strategies and associated with poor prognosis and relative ...
Abolfazl Yari +4 more
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Advanced Science, EarlyView.Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang +12 more
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BRAF Mutation Heterogeneity in Melanoma Lesions
Acta Dermato-Venereologica, 2020 is missing (Short communication)
Kaori Sakaizawa +3 more
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Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Клиническая и экспериментальная тиреоидология, 2020 Autophagy is an important intracellular process that supports cell death and survival. Oncogenesis is associated with a change in the AKT/mTOR signaling pathway status.
Liudmila V. Spirina +3 more
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