Results 51 to 60 of about 119,295 (311)

HER2 Status in RAS and BRAF Wild-Type Metastatic Colorectal Cancer: A Portuguese Study [PDF]

, 2023
Introduction: Colorectal cancer (CRC) is the second-most deadly cancer worldwide. However, there remains a scarcity of precision treatments available for this type of cancer.
Bonito, Nuno, Sousa, Maria João, Magalhães, José Paulo, Basto, Raquel, Sousa, Gabriela M, Paulo, Judy, Figueiredo, Paulo, Fraga, Teresa, Magalhães, Joana   +8 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Molecular genetics of follicular cell thyroid carcinoma

Клиническая и экспериментальная тиреоидология, 2016
Thyroid cancer is the most frequent endocrine malignancy. In the most cases thyroid cancer arises from follicular cells. Diagnosis of the cancer is based on the cytological analysis of fine needle aspiration biopsy of thyroid nodes.
Valentina D. Yakushina, Larisa V. Lerner, Tatiana P. Kazubskaya, Tatiana T. Kondrat'ieva, Somasundaram - Subramanian, Alexander V. Lavrov   +5 more
doaj   +1 more source

BRAF mutation in colorectal cancer: An update [PDF]

Archive of Oncology, 2023
Colon cancer is a leading cause of cancer-related deaths worldwide. About 10% of all colon cancer patients are found to have a mutation in BRAF proto-oncogene that arise as a result of a substitution of amino acid valine with glutamate at position 600 ...
Colombo Alfredo, Porretto Concetta Maria, Rosati Gerardo   +2 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Molecular landscape of borderline ovarian tumours: A systematic review

Open Medicine
Borderline ovarian tumours (BOTs) show intriguing characteristics distinguishing them from other ovarian tumours. The aim of the systematic review was to analyse the spectrum of molecular changes found in BOTs and discuss their significance in the ...
Sadlecki Pawel, Walentowicz-Sadlecka Malgorzata   +1 more
doaj   +1 more source

Phenotype-Genotype Correlation in Colorectal Cancer: A Real-Life Study

GE: Portuguese Journal of Gastroenterology, 2021
Background and Aims: Colorectal cancer (CRC) is a heterogeneous disease with distinctive genetic pathways, such as chromosomal instability, microsatellite instability and methylator pathway.
Catarina Frias-Gomes, Ana Carla Sousa, Inês Rolim, Ana Raquel Henriques, Francisco Branco, André Janeiro, Sara Malveiro, Ana Rita Dário, Maria Helena Oliveira, Paula Borralho, José Alberto Teixeira, Ana Faria, Rui Maio, Isabel Fonseca, Marília Cravo   +14 more
doaj   +1 more source

Prevalence of BRAF and NRAS mutations in cutaneous melanoma patients in Taiwan

, 2017
Background/Purpose: BRAF and NRAS mutations have been described in melanomas among Caucasians and some Asian populations. However, few large-scale studies have investigated the status and clinical significance of BRAF and NRAS mutations in a Taiwanese ...
紀秀華;廖怡華;朱家瑜;廖肇裕;沈宜萱, Sheen, Yi-Shuan;Liao, Yi-Hua;Liau, Jau-Yu;Lin, Ming-Hsien;Hsieh, Yi-Chun;Jee, Shiou-Hwa;Chu, Chia-Yu   +1 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition

JCO Precision Oncology, 2020
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes with current chemoradiotherapy strategies. Our aim was to study the role of targeted BRAF inhibition in these tumors. PATIENTS AND METHODS We collected clinical, imaging, molecular, and outcome information from patients with BRAF V600E–mutated glioma treated with
Nobre L., Zapotocky M., Ramaswamy V., Ryall S., Bennett J., Alderete D., Guill J. B., Baroni L., Bartels U., Bavle A., Bornhorst M., Boue D. R., Canete A., Chintagumpala M., Coven S. L., Cruz O., Dahiya S., Dirks P., Dunkel I. J., Eisenstat D., Conter C. F., Finch E., Finlay J. L., Frappaz D., Garre M. L., Gauvain K., Bechensteen A. G., Hansford J. R., Harting I., Hauser P., Hazrati L. -N., Huang A., Injac S. G., Iurilli V., Karajannis M., Kaur G., Kyncl M., Krskova L., Laperriere N., Larouche V., Lassaletta A., Leary S., Lin F., Mascelli S., McKeown T., Milde T., la Madrid A. M., Morana G., Morse H., Mushtaq N., Osorio D. S., Packer R., Pavelka Z., Quiroga-Cantero E., Rutka J., Sabel M., Salgado D., Solano P., Sterba J., Su J., Sumerauer D., Taylor M. D., Toledano H., Tsang D. S., Fernandes M. V., van Landeghem F., van Tilburg C. M., Wilson B., Witt O., Zamecnik J., Bouffet E., Hawkins C., Tabori U.   +72 more
openaire   +6 more sources