Results 1 to 10 of about 62,250 (302)

Mitochondrial DNA alteration in primary and metastatic colorectal cancer: Different frequency and association with selected clinicopathological and molecular markers

Tumor Biology, 2017
This study attempts to determine whether primary tumor tissue could reliably represent metastatic colorectal cancer in therapy-guiding analysis of mitochondrial microsatellite instability.
Britta Kleist, Thuja Meurer, Micaela Poetsch   +2 more
doaj   +1 more source

Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage

Gut Pathogens, 2020
Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP).
Yoshiki Okita, Minoru Koi, Koki Takeda, Ryan Ross, Bhramar Mukherjee, Erika Koeppe, Elena M. Stoffel, Joseph A. Galanko, Amber N. McCoy, Temitope O. Keku, Yoshinaga Okugawa, Takahito Kitajima, Yuji Toiyama, Eric Martens, John M. Carethers   +14 more
doaj   +1 more source

Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report

JTO Clinical and Research Reports
Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly ...
Emna Haddad, MD, Benjamin Bottet, MD, Pierre-Alain Thiebaut, MD, PhD, Samira Morin, MD, Hélène Dreyfus, MD, Élise Vannier, MD, Colette Vincent, MD, Florent Marguet, MD, PhD, Aude Lamy, PhD, Hagay Sobol, MD, PhD, Jean-Marc Baste, MD, PhD, Florian Guisier, MD, PhD, Jean-Christophe Sabourin, MD, PhD, Nicolas Piton, MD, PhD   +13 more
doaj   +1 more source

High incidence of microsatellite instability and loss of heterozygosity in three loci in breast cancer patients receiving chemotherapy: a prospective study

BMC Cancer, 2012
Background The aim of the study was to evaluate potential chemotherapy-induced microsatellite instability, loss of heterozygosity, loss of expression in mismatch repair proteins and associations with clinical findings in breast cancer patients ...
Kamat Nasir, Khidhir Mohammed A, Jaloudi Mohammed, Hussain Sabir, Alashari Mouied M, Al Qawasmeh Khaled H, Rannug Ulf   +6 more
doaj   +1 more source

Microsatellite instability in endometrial polyps [PDF]

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2010
To investigate the prevalence of microsatellite instability (MSI) in endometrial polyps and to evaluate whether there are clinical and histopathological parameters associated with this kind of instability.Between September 2008 and April 2009, endometrial polyps were collected from 109 patients. MSI was evaluated using the NCI recommended markers BAT25,
Salete S, Rios, Rosângela V, Andrade, Rinaldo W, Pereira, Nathan R, Wall, Khaled, Bahjri, Érica, Caldas, Larissa, Cavalcante, Florêncio, Figueiredo   +7 more
openaire   +2 more sources

Instability of a dinucleotide repeat in the 3′‐untranslated region (UTR) of the microsomal prostaglandin E synthase‐1 (mPGES‐1) gene in microsatellite instability‐high (MSI‐H) colorectal carcinoma

Molecular Oncology, 2015
DNA mismatch‐repair gene mutations, with consequent loss of functional protein expression, result in microsatellite instability (MSI). Microsatellite sequences are found in coding regions and in regulatory regions of genes (i.e., 5′‐UTRs and 3′‐UTRs). In
Durga Prasad Cherukuri, Joshua L. Deignan, Kingshuk Das, Wayne W. Grody, Harvey Herschman   +4 more
doaj   +1 more source

Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration

Biotechnology & Biotechnological Equipment, 2023
Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendritic ...
Maya Gulubova, Elina Aleksandrova, Yovcho Yovchev, Dimitar Chonov, Petio Chilingirov, Tatyana Vlaykova   +5 more
doaj   +1 more source

Low incidence of microsatellite instability in gastric cancers and its association with the clinicopathological characteristics: a comparative study

Scientific Reports, 2023
Gastric cancer is a complex heterogeneous disease with different molecular subtypes that have clinical implications. It is characterized by high mortality rates and limited effective therapies.
Fateme Fooladi Talari, Ali Bozorg, Sirous Zeinali, Mohammadreza Zali, Zhale Mohsenifar, Hamid Asadzadeh Aghdaei, Kaveh Baghaei   +6 more
doaj   +1 more source

Microsatellite instability in sacral chordoma [PDF]

Journal of Surgical Oncology, 2000
Microsatellite instability (MIN) is an indirect marker of globally defective DNA mismatch repair in the neoplastic cells of cancer patients. Chordomas are rare, primary skeletal malignancies for which few characteristic molecular genetic markers have been identified.
L, Klingler, J, Shooks, P N, Fiedler, A, Marney, M G, Butler, H S, Schwartz   +5 more
openaire   +2 more sources

Detection of mutator phenotype in Brazilian patients with acute and chronic myeloid leukemia

Genetics and Molecular Biology, 2004
The multisteps of tumorigenesis involve the classic chromosomal instability and the mutator phenotype pathways featured by a predisposition to acquire mutations in tumor suppressor genes and oncogenes.
Flávio Monteiro Ayres, Euza Guimarães Momotuk, Celso da Cunha Bastos, Aparecido Divino da Cruz   +3 more
doaj   +1 more source