Results 41 to 50 of about 62,250 (302)

Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters. [PDF]

PLoS ONE, 2015
Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa ...
Laura Staffa, Fabian Echterdiek, Nina Nelius, Axel Benner, Wiebke Werft, Bernd Lahrmann, Niels Grabe, Martin Schneider, Mirjam Tariverdian, Magnus von Knebel Doeberitz, Hendrik Bläker, Matthias Kloor   +11 more
doaj   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Durable response to pembrolizumab in microsatellite instability‐high advanced adrenocortical carcinoma

IJU Case Reports, 2023
Introduction Advanced adrenocortical carcinoma has a poor prognosis and is treated with chemotherapy that includes mitotane with etoposide, doxorubicin, and cisplatin as first‐line therapy.
Masaya Senda, Kohei Hashimoto, Tetsuya Shindo, Ko Kobayashi, Toshiaki Tanaka, Naoya Masumori   +5 more
doaj   +1 more source

Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy

Journal of Hematology & Oncology, 2019
Immunotherapies have led to substantial changes in cancer treatment and have been a persistently popular topic in cancer research because they tremendously improve the efficacy of treatment and survival of individuals with various cancer types.
Pengfei Zhao, Li Li, Xiaoyue Jiang, Qin Li   +3 more
doaj   +1 more source

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs

Journal of Veterinary Internal Medicine, 2022
Background Microsatellite instability (MSI) is a type of genomic instability caused by mismatch repair deficiency (dMMR) in tumors. Studies on dMMR/MSI are limited, and the relationship between dMMR and MSI is unknown in tumors of dogs.
Sakuya Inanaga, Masaya Igase, Yusuke Sakai, Kenji Hagimori, Hiroshi Sunahara, Hiro Horikirizono, Kazuhito Itamoto, Kenji Baba, Yoshiharu Ohsato, Takuya Mizuno   +9 more
doaj   +1 more source

Analysis of microsatellite instability in medulloblastoma [PDF]

Neuro-Oncology, 2009
Medulloblastoma is the most common malignant brain tumor in children. The presence of microsatellite instability (MSI) in brain tumors, particularly medulloblastomas, has not been properly addressed. The aim of the present study was to evaluate the role of MSI in medulloblastoma carcinogenesis. MSI status was determined in 36 patients using a pentaplex
Pereira, Marta Sofia Carvalho Ribeiro Viana, Almeida, Inês, Sousa, Sónia, Mahler-Araújo, Bethânia, Seruca, Raquel, Pimentel, José, Reis, R. M.   +6 more
openaire   +3 more sources

Uterine carcinosarcoma with microsatellite instability - does immunotherapy modify the therapeutic scenario? A case report and literature review

, 2023
Carcinosarcomas were reclassified by World Health Organization as high-grade uterine carcinomas in 2014. Due to its rare histology, comprising only 5% of uterine carcinomas, there is a small representation of this tumor in studies that evaluate ...
Isabela Panzeri Carlotti Buzatto, Angelica Nogueira-Rodrigues, Danilo Tadao Wada, Diocesio Alves Pinto Andrade, Andreia Cristina Melo, Eduardo Paulino, Warne Pedro Andrade   +6 more
core   +1 more source

High prevalence of NTRK fusions in sporadic dMMR/MSI mCRC RAS/RAF wild-type: an opportunity for a post-immune checkpoint inhibitors progression rescue strategy

ESMO Gastrointestinal Oncology
Background: Currently, mismatch repair deficient/microsatellite instable (dMMR/MSI) status constitutes a validated predictive marker of response to immune checkpoint inhibitors (ICIs) in patients with metastatic colorectal cancer (mCRC).
M. Svrcek, A. Cayre, T. Samaille, R. Colle, L. Mas, P. Bourgoin, E. Guillerm, R. Cohen, F. Penault-Llorca, T. André, N. Radosevic-Robin   +10 more
doaj   +1 more source

Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity

, 2004
Background Colorectal cancers displaying high-degree microsatellite instability (MSI-H) have an improved prognosis compared to microsatellite stable (MSS) cancers.
Huang Fei, Bustin, SA, Shaw Peter M, Roger Feakins, Hands Rebecca E, Banerjea, A, Fei Huang, Stephen A Bustin, Bustin Stephen A, Han Xia, Dorudi, S, Shafi Ahmed, Ayan Banerjea, Hands, RE, Ahmed, S, Feakins, R, Han, X, Feakins Roger, Sina Dorudi, Shaw, PM, Peter M Shaw, Banerjea Ayan, Xia Han, Huang, F, Rebecca E Hands, Dorudi Sina, Ahmed Shafi   +26 more
core   +1 more source

A molecular portrait of microsatellite instability across multiple cancers

Nature Communications, 2017
Some cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to
Isidro Cortes-Ciriano, Sejoon Lee, Woong-Yang Park, Tae-Min Kim, Peter J. Park   +4 more
doaj   +1 more source