Results 31 to 40 of about 52,582 (257)

Mitochondrial DNA alteration in primary and metastatic colorectal cancer: Different frequency and association with selected clinicopathological and molecular markers

Tumor Biology, 2017
This study attempts to determine whether primary tumor tissue could reliably represent metastatic colorectal cancer in therapy-guiding analysis of mitochondrial microsatellite instability.
Britta Kleist, Thuja Meurer, Micaela Poetsch   +2 more
doaj   +1 more source

Mismatch Repair Deficiency and Microsatellite Instability

Encyclopedia, 2022
Mismatch repair deficiency (MMRd) is caused by the biallelic inactivation of an MMR gene, which can be attributed either to an inherited or an acquired pathway.
Sandra Schöniger, Josef Rüschoff
doaj   +1 more source

Analysis of microsatellite instability in medulloblastoma [PDF]

Neuro-Oncology, 2009
Medulloblastoma is the most common malignant brain tumor in children. The presence of microsatellite instability (MSI) in brain tumors, particularly medulloblastomas, has not been properly addressed. The aim of the present study was to evaluate the role of MSI in medulloblastoma carcinogenesis. MSI status was determined in 36 patients using a pentaplex
Pereira, Marta Sofia Carvalho Ribeiro Viana, Almeida, Inês, Sousa, Sónia, Mahler-Araújo, Bethânia, Seruca, Raquel, Pimentel, José, Reis, R. M.   +6 more
openaire   +3 more sources

Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage

Gut Pathogens, 2020
Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP).
Yoshiki Okita, Minoru Koi, Koki Takeda, Ryan Ross, Bhramar Mukherjee, Erika Koeppe, Elena M. Stoffel, Joseph A. Galanko, Amber N. McCoy, Temitope O. Keku, Yoshinaga Okugawa, Takahito Kitajima, Yuji Toiyama, Eric Martens, John M. Carethers   +14 more
doaj   +1 more source

Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report

JTO Clinical and Research Reports
Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly ...
Emna Haddad, MD, Benjamin Bottet, MD, Pierre-Alain Thiebaut, MD, PhD, Samira Morin, MD, Hélène Dreyfus, MD, Élise Vannier, MD, Colette Vincent, MD, Florent Marguet, MD, PhD, Aude Lamy, PhD, Hagay Sobol, MD, PhD, Jean-Marc Baste, MD, PhD, Florian Guisier, MD, PhD, Jean-Christophe Sabourin, MD, PhD, Nicolas Piton, MD, PhD   +13 more
doaj   +1 more source

Instability of a dinucleotide repeat in the 3′‐untranslated region (UTR) of the microsomal prostaglandin E synthase‐1 (mPGES‐1) gene in microsatellite instability‐high (MSI‐H) colorectal carcinoma

Molecular Oncology, 2015
DNA mismatch‐repair gene mutations, with consequent loss of functional protein expression, result in microsatellite instability (MSI). Microsatellite sequences are found in coding regions and in regulatory regions of genes (i.e., 5′‐UTRs and 3′‐UTRs). In
Durga Prasad Cherukuri, Joshua L. Deignan, Kingshuk Das, Wayne W. Grody, Harvey Herschman   +4 more
doaj   +1 more source

High incidence of microsatellite instability and loss of heterozygosity in three loci in breast cancer patients receiving chemotherapy: a prospective study

BMC Cancer, 2012
Background The aim of the study was to evaluate potential chemotherapy-induced microsatellite instability, loss of heterozygosity, loss of expression in mismatch repair proteins and associations with clinical findings in breast cancer patients ...
Kamat Nasir, Khidhir Mohammed A, Jaloudi Mohammed, Hussain Sabir, Alashari Mouied M, Al Qawasmeh Khaled H, Rannug Ulf   +6 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration

Biotechnology & Biotechnological Equipment, 2023
Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendritic ...
Maya Gulubova, Elina Aleksandrova, Yovcho Yovchev, Dimitar Chonov, Petio Chilingirov, Tatyana Vlaykova   +5 more
doaj   +1 more source

Microsatellite instability in colorectal cancer

EXCLI journal, 2018
EXCLI Journal; 17:Doc159; ISSN 1611 ...
Nojadeh, Jafar Nouri, Sharif, Shahin Behrouz, Sakhinia, Ebrahim   +2 more
openaire   +3 more sources