Results 31 to 40 of about 62,250 (302)
Experimental Hematology & Oncology, 2021 The development of programmed cell death-1 inhibitor (PD-1) has shed light on the treatment of tumors with deficiencies in DNA mismatch repair system or microsatellite instability (dMMR/MSI). However, predicting the subset in this group that will benefit
Qiao-Xuan Wang +6 more
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Microsatellite Instability in Colorectal Cancer [PDF]
Gastroenterology, 2010 Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of these are associated with Lynch syndrome and the other 12% are caused by sporadic, acquired hypermethylation of the promoter of the MLH1 gene, which occurs in tumors with the ...
C Richard, Boland, Ajay, Goel
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Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]
, 2004 Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Gross, M. +9 more
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Microsatellite instability analysis.
, 2022 (A) Examples of microsatellite loci analyzed using the Agilent 2100 Bioanalyzer. Blue and red lines represent tumor tissue and normal tissue, respectively.
Fernando Benavides (29259) +14 more
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Microsatellite Instability in Yeast: Dependence on the Length of the Microsatellite [PDF]
Genetics, 1997 One of the most common microsatellites in eukaryotes consists of tandem arrays [usually 15-50 base pairs (bp) in length] of the dinucleotide GT. We examined the rates of instability for poly GT tracts of 15, 33, 51, 99 and 105 bp in wild-type and mismatch repair-deficient strains of Saccharomyces cerevisiae. Rates of instability increased more than two
M, Wierdl, M, Dominska, T D, Petes
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Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer. [PDF]
, 2012 Thus, we evaluated the immunofluorescence pattern of TRAIL-receptors and E-cadherin to assess the fraction of membrane-bound TRAIL-receptors in 231 selected patients with early-stage CRC undergoing surgical treatment only.
Göke, Burkhard +32 more
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Microsatellite Instability in Malignant Melanoma [PDF]
Cancer Genetics and Cytogenetics, 1998 Defective mismatch repair has been detected in human colorectal and endometrial carcinomas which exhibit microsatellite instability (MIN). The purpose of this study was to search for MIN in melanoma. Paraffin-embedded neoplastic and non-neoplastic control cells were obtained from 20 untreated individuals with cutaneous malignant melanoma.
V R, Talwalkar +4 more
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Genome Medicine, 2021 We developed a sensitive sequencing approach that simultaneously profiles microsatellite instability, chromosomal instability, and subclonal structure in cancer. We assessed diverse repeat motifs across 225 microsatellites on colorectal carcinomas.
GiWon Shin +10 more
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BMC Cancer, 2022 Background As a transmembrane protein, C-type lectin-like receptor 2 (CLEC-2) is mainly expressed on platelets and released into plasma after platelet activation. Activated platelets participate in the regulation of innate immune cells.
Xin Zhang +5 more
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Tumor Biology, 2017 Postreplicative mismatch repair safeguards the stability of our genome. The defects in its functioning will give rise to microsatellite instability. In this study, 50 meningiomas were investigated for microsatellite instability. Two major mismatch repair
Nives Pećina-Šlaus +5 more
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