Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9 [PDF]
Molecular Cell, 2017 Summary Transcription of expanded microsatellite repeats is associated with multiple human diseases, including myotonic dystrophy, Fuchs’ endothelial corneal dystrophy, and C9orf72 -ALS/FTD.
Maurice Swanson +2 more
exaly +6 more sources
Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors [PDF]
Cell Genomics, 2022 Summary: Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1.
Y. Esther Tak +16 more
doaj +2 more sources
Discrepancy variation of dinucleotide microsatellite repeats in eukaryotic genomes [PDF]
Biological Research, 2009 To address whether there are differences of variation among repeat motif types and among taxonomic groups, we present here an analysis of variation and correlation of dinucleotide microsatellite repeats in eukaryotic genomes.
HUAN GAO +4 more
doaj +4 more sources
Development and characterization of microsatellite markers for Chaeturichthys stigmatias (Actinopterygii: Gobiiformes: Gobiidae) based on restriction site-associated DNA sequencing (RAD-seq) [PDF]
Acta Ichthyologica et Piscatoria, 2022 Chaeturichthys stigmatias Richardson, 1844, a fish species of the family Gobiidae, is an offshore warm-temperate fish species and a dominant component of estuarine ecosystems.
Bingjie Chen +4 more
doaj +3 more sources
Genomic microsatellite characteristics analysis of Dysomma anguillare (Anguilliformes, Dysommidae), based on high-throughput sequencing technology [PDF]
Biodiversity Data Journal, 2023 Microsatellite loci were screened from the genomic data of Dysomma anguillare and their composition and distribution were analysed by bioinformatics for the first time.
Ziyan Zhu +4 more
doaj +3 more sources
Fast and cost-effective mining of microsatellite markers using NGS technology: an example of a Korean water deer Hydropotes inermis argyropus. [PDF]
PLoS ONE, 2011 BACKGROUND: Microsatellites, a special class of repetitive DNA sequence, have become one of the most popular genetic markers for population/conservation genetic studies.
Jeong-Nam Yu +4 more
doaj +1 more source
BMC Genomics, 2021 Background Microsatellite repeats are ubiquitous in organism genomes and play an important role in the chromatin organization, regulation of gene activity, recombination and DNA replication. Although microsatellite distribution patterns have been studied
Yi Lei +3 more
doaj +1 more source
Microsatellite repeat instability and neurological disease [PDF]
BioEssays, 2009 AbstractOver 20 unstable microsatellite repeats have been identified as the cause of neurological disease in humans. The repeat nucleotide sequences, their location within the genes, the ranges of normal and disease‐causing repeat length and the clinical outcomes differ.
Brouwer, JR (Jaap) +2 more
openaire +3 more sources
Systematic microsatellite repeat expansion cloning and validation [PDF]
Human Genetics, 2020 Approximately 3% of the human genome is composed of short tandem repeat (STR) DNA sequence known as microsatellites, which can be found in both coding and non-coding regions. When associated with genic regions, expansion of microsatellite repeats beyond a critical threshold causes dozens of neurological repeat expansion disorders.
Kushal J. Rohilla +5 more
openaire +2 more sources
Genome-wide distribution and organization of microsatellites in plants: an insight into marker development in Brachypodium. [PDF]
PLoS ONE, 2011 Plant genomes are complex and contain large amounts of repetitive DNA including microsatellites that are distributed across entire genomes. Whole genome sequences of several monocot and dicot plants that are available in the public domain provide an ...
Humira Sonah +8 more
doaj +1 more source