Impeding Transcription of Expanded Microsatellite Repeats by Deactivated Cas9 [PDF]
Molecular Cell, 2017 SummaryTranscription of expanded microsatellite repeats is associated with multiple human diseases, including myotonic dystrophy, Fuchs’ endothelial corneal dystrophy, andC9orf72-ALS/FTD.
Tanvi Saxena +2 more
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RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration [PDF]
Frontiers in Genetics, 2022 Short repeated sequences of 3−6 nucleotides are causing a growing number of over 50 microsatellite expansion disorders, which mainly present with neurodegenerative features. Although considered rare diseases in relation to the relatively low number of cases, these primarily adult-onset conditions, often debilitating and fatal in absence of a cure ...
Lydia M. Castelli +4 more
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Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors. [PDF]
Cell Genom, 2022 Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1.
Tak YE +16 more
europepmc +2 more sources
MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion
Science, 2021 International audienceThe Rett syndrome protein MeCP2 was described as a methyl-CpG-binding protein, but its exact function remains unknown. Here we show that mouse MeCP2 is a microsatellite binding protein that specifically recognizes hydroxymethylated ...
Abdulkhaleg Ibrahim +2 more
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Chromosomal distribution of microsatellite repeats in Amazon cichlids genome (Pisces, Cichlidae). [PDF]
Comp Cytogenet, 2015 Schneider CH +5 more
europepmc +3 more sources
MRD: a microsatellite repeats database for prokaryotic and eukaryotic genomes. [PDF]
, 2002 MRD is a database system to access the microsatellite repeats information of genomes such as archea, eubacteria, and other eukaryotic genomes whose sequence information is available in public domains. MRD stores information about simple tandemly repeated
Subbaya Subramanian +6 more
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, 2011 Two approaches to modeling microsatellite DNA repeats are considered. The former is an infinite dimensional system based on the theory of branching random walks which dynamic properties are characterized using Laplace transforms and Laplace asymptotic ...
Małgorzata Białka
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Stabilization of Microsatellite Sequences by Variant Repeats in the Yeast Saccharomyces Cerevisiae
, 2020 We examined the effect of a single variant repeat on the stability of a 51-base pair (bp) microsatellite (poly GT). We found that the insertion stabilizes the microsatellite about fivefold in wild-type strains.
The University of North Carolina at Chapel Hill University Libraries
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Combined Microsatellite Instability and Elevated Microsatellite Alterations at Selected Tetranucleotide Repeats (EMAST) Might Be a More Promising Immune Biomarker in Colorectal Cancer [PDF]
Oncologist, 2019 Ming-Huang Chen +2 more
exaly +2 more sources
Distribution of Polymorphic and Non-Polymorphic Microsatellite Repeats in
Bioinformatics and Biology Insights, 2008 The results of our bioinformatics analysis have found over 91,000 di-, tri-, and tetranucleotide microsatellites in our survey of 25% of the X. tropicalis genome, suggesting there may be over 360,000 within the entire genome. Within the X.
Dan E. Wells +5 more
core +3 more sources