Results 1 to 10 of about 116,020 (268)
Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers
Cancers, 2021 Activating mutations in KRAS are present in 25% of human cancers. When mutated, the KRAS protein becomes constitutively active, stimulating various effector pathways and leading to the deregulation of key cellular processes, including the suppression of apoptosis and enhancement of proliferation.
Yuta Adachi +3 more
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Ewolucja pozycji Narodowego Banku Polskiego w polityce makroostrożnościowej
Seminare, 2022 Artykuł poświęcony jest pozycji Narodowego Banku Polskiego w nadzorze makroostrożnościowym. Pierwotnie za nadzór makroostrożnościowy w Polsce miała odpowiadać Rada Ryzyka Systemowego, w której próbowano zagwarantować wiodącą rolę NBP z różnym nasileniem.
Ireneusz Kraś
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Structure, 2017 Mutations in members of the RAS family of small GTPases have been associated with numerous human cancers. However, RAS family members are notoriously difficult to target. In this issue of Structure, Lu et al. (2017) examine the effects of two compounds with distinct chemical scaffolds on the structure and dynamics of an oncogenic KRAS mutant, thus ...
Daniel J, Deredge, Patrick L, Wintrode
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Evaluation of the Role of the KRAS Gene Polymorphism LCS6 (rs61764370) in Iraqi Women with Ovarian Cancer [PDF]
Archives of Razi Institute, 2022 In carcinogenesis, KRAS is an essential oncogene that plays a key function. The polymorphism of rs61764370 is a candidate for cancer susceptibility in KRAS3' untranslated region.
M Ghazi Jumaa
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Cold Spring Harbor Perspectives in Medicine, 2018 Oncogenic Kras are genetic dependencies for the majority of pancreatic and colorectal adenocarcinomas; however, much remains to be understood regarding its tropism to these carcinomas. Recently developed organoid technology presents a more representative model culture system for pancreatic and colon epithelial tissues as well as better fostering the ...
Derek, Cheng, David, Tuveson
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Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2022 Colorectal cancer is one of the most frequently diagnosed malignant tumors in men and women, which is a highly heterogeneous group of neoplasms consisting of subclasses with different molecular and clinical characteristics, and, as a consequence ...
A. N. Toropovskiy +5 more
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The prevalence of KRAS and BRAF mutation in colorectal cancer patients in Bali
Indonesian Journal of Biotechnology, 2022 Mutations in the KRAS (Kirsten rat sarcoma viral oncogene homolog gene) and BRAF (v‐Raf murine sarcoma viral oncogene homolog B1) gene play a significant role in primary resistance to colorectal cancer therapy.
Ayu Dewi Ni Nyoman +4 more
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Gradišča Komenskega Krasa v starejši železni dobi
Arheološki Vestnik, 2021 Prispevek prinaša nova spoznanja o poselitvi Komenskega Krasa v starejši železni dobi. Podrobneje so obravnavana tri v arheološki literaturi že znana najdišča, to so Tomaj, Štanjel in Zagrajec, kjer so bile v zadnjih desetletjih izvedene arheološke ...
Patricija BRATINA
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Notranjska v pozni bronasti in starejši železni dobi
Arheološki Vestnik, 2021 Prispevek v uvodnem delu prinaša pregled zgodovine raziskav prazgodovinskih najdišč na Notranjskem. V nadaljevanju so predstavljene tri arheološke lokacije, ki dobro zaobjamejo pozno bronasto in starejšo železno dobo notranjske halštatske skupnosti ...
Alma BAVDEK
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Menulis Teks Eksplanasi Ilmiah Dengan Menggunakan Media Media Flash Card
Ibriez: Jurnal Kependidikan Dasar Islam Berbasis Sains, 2019 Kemampuan menulis kelas VI sekolah dasar adalah kemampuan menulis teks penjelasan (eksplanasi) dengan menggunakan kosa kata baku dan kalimat efektif. Namun pada kenyataannya, siswa kelas VI SDN Rejomulyo 1 Kras Kediri masih kesulitan menulis karangan ...
Bambang Setyawan
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