Results 11 to 20 of about 116,020 (268)

The Religious Policy of Sigismund I and Sigismund II Augustus in the Reformation Period: status quaestionis

open access: yesActa Historica Universitatis Klaipedensis, 2014
The article examines the role of the last Jagiellonian monarchs, Sigismund I (1506-1548) and his son Sigismund II Augustus (1548-1572), in promoting and securing religious peace in the multi-confessional society of the 16th-century Rzeczpospolita.
Paweł Kras
doaj   +1 more source

INFLUENCE OF SOMATIC MUTATIONS OF KRAS, NRAS, BRAF AND MICROSATELLITE INSTABILITY STATUS ON SURVIVAL OF COLORECTAL CANCER PATIENTS WITH PERITONAL CARCINO

open access: yesСибирский онкологический журнал, 2020
Purpose: to evaluate the effect of somatic mutations of the KRAS, NRAS, BRAF genes and the status of microsatellite instability on the overall and disease-free survival of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal ...
V. P. Shubin   +6 more
doaj   +1 more source

Malignant Melanoma within a Cellular Blue Nevi Presenting as a Vascular Malformation and the Connection to Sporadic KRAS Mutations

open access: yesCase Reports in Dermatology, 2021
We present a case of malignant melanoma (MM) developing within a vascular malformation showing features of cellular blue nevi. A 47-year-old male presented with acute symptoms of a temporal and zygomatic mass, which were both previously asymptomatic upon
Felicia Tai   +5 more
doaj   +1 more source

Detection of activating mutations in RAS/RAF/MEK/ERK and JAK/STAT signaling pathways [PDF]

open access: yesТерапевтический архив, 2020
Issue.The study of activating mutations (NRAS,KRAS,FLT3,JAK2,CRLF2genes) of RAS/RAF/MEK/ERK and JAK/STAT signaling pathways in B-cell acute lymphoblastic leukemia (B-ALL) in adult patients which are included in Russian multicenter clinical trials ...
K. I. Zarubina   +13 more
doaj   +1 more source

KRAS: Druggable at Last

open access: yesThe Oncologist, 2023
The approval of adagrasib for non–small cell lung cancer is a milestone in drug development. This commentary highlights the history of the research that led to this breakthrough that will help many patients with KRAS-mutated cancers to live longer and better.
Benjamin O Herzberg, Gulam A Manji
openaire   +2 more sources

Nesting of Eurasian Crag Martin (Ptyonoprogne rupestris) in the Malá Fatra Mts. in Slovakia

open access: yesTichodroma, 2022
We detected occurrence and nesting of Eurasian Craig Martin (Ptyonoprogne rupestris) for the first time in Slovakia. One nesting pair with four juveniles was detected during the 2022 nesting season in the Malá Fatra mountains.
Štefan Matis   +2 more
doaj   +1 more source

Molecular genetic testing in colon cancer: clinical aspects

open access: yesAlʹmanah Kliničeskoj Mediciny, 2022
Molecular genetic diagnostics is an essential element to plan for management of colorectal cancer (CRC) patients. The choice of systemic treatment for CRC is impossible without molecular testing of the tumor.
Aleksandr S. Martianov   +3 more
doaj   +1 more source

„Jak chwytać lisy w Pańskiej winnicy”? Treści antyheretyckie w kazaniach św. Bernarda z Clairvaux i Hélinanda z Froidmont

open access: yesRoczniki Historyczne, 2014
„Wie sollen die Füchse im Weinberg des Herrn gefangen werden?” Antihäretische Inhalte in den Predigten Bernhards von Clairvaux und Helinands von Froidmont Zusammenfassung Seit der Mitte des 12.
Paweł Kras
doaj   +1 more source

Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors

open access: yesOncoImmunology, 2021
T-cell receptor (TCR) redirected T cells are considered as the next generation of care for the treatment of numerous solid tumors. KRAS mutations are driver neoantigens that are expressed in over 25% of all cancers and are thus regarded as ideal targets ...
Pierre Dillard   +7 more
doaj   +1 more source

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