Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy [PDF]
Molecular Cancer, 2019 Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets KRAS may provide a more attractive option for the treatment of KRAS-mutant lung cancer.Here we identified a small molecule ...
Ke Xu +8 more
openaire +3 more sources
Nesting of Eurasian Crag Martin (Ptyonoprogne rupestris) in the Malá Fatra Mts. in Slovakia
Tichodroma, 2022 We detected occurrence and nesting of Eurasian Craig Martin (Ptyonoprogne rupestris) for the first time in Slovakia. One nesting pair with four juveniles was detected during the 2022 nesting season in the Malá Fatra mountains.
Štefan Matis +2 more
doaj +1 more source
Molecular genetic testing in colon cancer: clinical aspects
Alʹmanah Kliničeskoj Mediciny, 2022 Molecular genetic diagnostics is an essential element to plan for management of colorectal cancer (CRC) patients. The choice of systemic treatment for CRC is impossible without molecular testing of the tumor.
Aleksandr S. Martianov +3 more
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High-Resolution Three-Dimensional NMR Structure Of The KRAS Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation [PDF]
, 2017 Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4).
Ivashchenko, S. +5 more
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Acta Historica Universitatis Klaipedensis, 2014 The article examines the role of the last Jagiellonian monarchs, Sigismund I (1506-1548) and his son Sigismund II Augustus (1548-1572), in promoting and securing religious peace in the multi-confessional society of the 16th-century Rzeczpospolita.
Paweł Kras
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Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
OncoImmunology, 2021 T-cell receptor (TCR) redirected T cells are considered as the next generation of care for the treatment of numerous solid tumors. KRAS mutations are driver neoantigens that are expressed in over 25% of all cancers and are thus regarded as ideal targets ...
Pierre Dillard +7 more
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RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis [PDF]
, 2016 Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here,
Algül, Hana +17 more
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Biomarker series: KRAS- A narrative review
Cancer Research, Statistics, and Treatment, 2021 Non-small cell lung cancer (NSCLC) has emerged as the poster child of molecular medicine. Kirsten rat sarcoma (KRAS)-mutated NSCLC is a common yet heterogeneous entity with distinct clinical and prognostic characteristics.
Ullas Batra, Shrinidhi Nathany
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Katalog husytów i osób podejrzewanych o husytyzm w piętnastowiecznej Polsce
Archiwa, Biblioteki i Muzea Kościelne, 2000 -
Paweł Kras
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Retreatment with anti-EGFR based therapies in metastatic colorectal cancer: impact of intervening time interval and prior anti-EGFR response. [PDF]
, 2015 BackgroundThis retrospective study aims to investigate the activity of retreatment with anti-EGFR-based therapies in order to explore the concept of clonal evolution by evaluating the impact of prior activity and intervening time interval.MethodsEighty ...
Eng, C +20 more
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