Results 31 to 40 of about 151,900 (300)
Active vibration control unit with a flywheel inertial actuator
, 2020 This paper presents simulation and experimental results on the implementation of a velocity feedback control unit with a new flywheel inertial actuator, which can be used to reduce flexural vibration of distributed structures. The actuator incorporates
Kras A., Gardonio P.
core +1 more source
KRAS-G12C in the crosshairs [PDF]
Nature Reviews Cancer, 2019 Two papers report the discovery and preclinical analyses of two different covalent inhibitors of KRAS-G12C (AMG 510 and MRTX849) as well as the first data on the efficacy of these inhibitors in cancer patients.
openaire +2 more sources
Research Progress of Proteolysis Targeting Chimeria in NSCLC Therapy
Chinese Journal of Lung Cancer, 2022 Proteolysis targeting chimeria (PROTAC) degrades target proteins by utilizing the ubiquitin-proteasome pathway, subverting the concept of traditional small molecule inhibitors.
Lin JIANG +4 more
doaj +1 more source
The Oncologist, 2023 The approval of adagrasib for non–small cell lung cancer is a milestone in drug development. This commentary highlights the history of the research that led to this breakthrough that will help many patients with KRAS-mutated cancers to live longer and better.
Benjamin O Herzberg, Gulam A Manji
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ANALYSIS OF MUTATIONS IN KRAS AND BRAF GENES IN COLORECTAL CANCER IN RUSSIAN PATIENTS
Сибирский онкологический журнал, 2016 Mutations in KRAS and BRAF genes in 80 colorectal cancer (CRC) samples from Russian patients were tested using two methods: 1) allele-specific real-time PCR (as-rt PCR) and 2) wild-type blocking PCR with Sanger sequencing (WTBS).
E. E. Pisareva +3 more
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PolitejaThe article is devoted to the Financial Stability Committee, which bridged the institutional gap that emerged after the 2008 crisis. The purpose of the paper is to analyse its institutional and legal capacity for macro-prudential supervision.
Ireneusz Kraś
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Somatic mutation testing: the role in differential diagnosis of thyroid neoplasms [PDF]
Эндокринная хирургия, 2019 Background: In the preoperative diagnosis of thyroid tumors the cytological examination of the material of fine needle aspiration biopsy is the gold standard and serves as the basis for planning of treatment strategy.
Vera A. Kachko +5 more
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Biological Resectability in Colorectal Liver Metastases: A Nomogram-Based Continuous Risk Model to Define Borderline Disease. [PDF]
Ann Gastroenterol SurgKRAS mutation demonstrated a prognostic impact according to primary tumor sidedness, independent of tumor morphology, in patients undergoing hepatectomy for colorectal liver metastases. A nomogram integrating biological and clinicopathological factors was developed to provide continuous biological risk assessment.
Umeda Y +9 more
europepmc +2 more sources
Roczniki HistoryczneW styczniu 1480 r., przed sądem biskupa włocławskiego Zbigniewa Oleśnickiego rozpoczęły się przesłuchania mieszkańców Inowrocławia w sprawie miejscowych sympatyków husytyzmu.
Paweł Kras
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Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer
OncoImmunology, 2020 Oncogenic KRAS-mutant lung cancers remain treatment refractory. A better understanding of the immune response of KRAS-mutant lung cancers is required to facilitate the development of potential therapeutic strategies.
Byung-Seok Kim +3 more
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