Results 61 to 70 of about 119,295 (311)

BRAF mutations in low-grade serous ovarian cancer and response to BRAF inhibition

, 2018
© 2019 American Society of Clinical Oncology. Purpose Low-grade serous ovarian carcinoma (LGSC) responds poorly to chemotherapy and is characterized by activating mutations in the Ras sarcoma-mitogen-activated protein kinase (RAS-MAPK) pathway, including
Wain, GV, Kennedy, CJ, Saunders, C, Balleine, RL, Gao, B, Hogg, R, Kan, C, Traficante, N, Etemadmoghadam, D, Srirangan, S, Hung, J, Fereday, S, Chiew, YE, Moujaber, T, et al.   +14 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Dabrafenib: A narrative drug review

Cancer Research, Statistics, and Treatment, 2020
Activating mutations in the BRAF gene lead to an unregulated downstream signaling of the MAPK/extracellular-signal-regulated kinase pathway. This pathway is implicated in a range of solid tumors, and BRAF inhibitors are an attractive option in the ...
Lakhan Kashyap, Saswata Saha, Anne Srikanth   +2 more
doaj   +1 more source

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion [PDF]

, 2013
Background Prevalence of colorectal cancer (CRC) in the British Bangladeshi population (BAN) is low compared to British Caucasians (CAU). Genetic background may influence mutations and disease features.
Sengupta, N, Silver Andrew, Suraweera, Nirosha, Sieber, O, Sakthianandeswaren, A, Oliver Sieber, Suraweera, N, Yau, C, Jean-Baptiste Cazier, Yau, Christopher, Andrew Silver, Sieber Oliver, Lai, Cecilia, Yau Christopher, Guadalupe Polanco-Echeverry, Mouradov, Dmitri, Neel Sengupta, Sieber, Oliver, Suraweera Nirosha, Christopher Yau, Sengupta Neel, Dorudi, Sina, Feakins, R, Cazier, Jean-Baptiste, Feakins Roger, Gibbs, Peter, Sina Dorudi, Cecilia Lai, Cazier, J-B, Silver, Andrew, Peter Gibbs, Ahmed Shafi, Ahmed, Shafi, David Propper, Propper David, Thaha, M, Sakthianandeswaren Anuratha, Silver, A, Anil Ghosh, Roger Feakins, Polanco-Echeverry Guadalupe, Ghosh, Anil, Sengupta, Neel, Mohamed Thaha, Ghosh Anil, Mouradov Dmitri, Cazier Jean-Baptiste, Propper, David, Thaha Mohamed, Nirosha Suraweera, Cazier, Jean-Baptiste; id_orcid, Cazier, JB, Lai Cecilia, Dorudi, S, Anuratha Sakthianandeswaren, Ghosh, A, Shafi Ahmed, Mouradov, D, Ahmed, S, Gibbs Peter, Lai, C, Feakins, Roger, Polanco-Echeverry, G, Thaha, Mohamed, Dorudi Sina, Polanco-Echeverry, Guadalupe, Sakthianandeswaren, Anuratha, Gibbs, P, Propper, D, Dmitri Mouradov   +69 more
core   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Melanoma: clinical-pathological and molecular analysis in patients of Ibague city, Colombia

Duazary, 2020
This study aimed to establish the clinicopathological characteristics of patients with melanoma and its association with BRAF gene mutations. The pathology reports and paraffin-embedded tumor samples from 47 women and 30 men with melanoma, with an ...
Carlos Puentes, Ana Estrada, Mabel Bohórquez, Anggi Vélez, Carlos Giraldo, Magdalena Echeverry   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients

Acta Medica Bulgarica, 2021
Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development.
Vidinov K., Dodova R., Mitev P., Mitkova A., Dimitrova I., Shinkov A., Ivanova R., Mitev V., Kaneva R.   +8 more
doaj   +1 more source

A Hybrid Bioprinting–Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity

Advanced Healthcare Materials, EarlyView.
This work introduces a “cancer‐in‐a‐well” technology that recreates tumor heterogeneity in vitro using multitype spheroid arrays. Combining bioprinting/microdispensing with microstructured culture devices, the system improves drug screening and modeling of tumor complexity.
Simone Bonetti, Eva Clemente, Emanuela Mensà, Marco de Maria, Fulvia Farabegoli, Emanuela Saracino, Barbara Bortolani, Emanuela Marcelli, Renato Brandimarti, Dario de Biase, Giampaolo Zuccheri   +10 more
wiley   +1 more source

Comparison of First-Line FOLFOX versus FOLFIRI in RAS Mutant Metastatic Colorectal Cancer Patients

Journal of Oncological Sciences
Objective: Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality, with rat sarcoma (RAS) and proto-oncogene B-raf (BRAF) mutations associated with worse prognosis in metastatic settings.
Alper TOPAL, Goncagül AKDAĞ, Ayşegül DUMLUDAĞ, Çağlar KÖSEOĞLU, Ömer Faruk KUZU, Hüseyin ATACAN, Baran Can AYTAÇ, Gizem YILDIRIM, Sedat YILDIRIM, Hacer Şahika YILDIZ, Gülsema YILDIRAN KESKİN, Nuri KARADURMUŞ   +11 more
doaj   +1 more source