Results 41 to 50 of about 367,883 (311)

Idiopathic Pulmonary Fibrosis and Hypersensitive Pneumonitis: A Fresh View on The Role of Genetic and Epigenetic Factors in The Development and Course of Diseases

Архивъ внутренней медицины
Given their ubiquitous progressive nature and unfavorable prognosis, interstitial lung diseases (ILD), especially such common variants as idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP), rightly attract considerable attention ...
E. E. Arkhangelskaya, S. V. Lyamina, E. O. Kozhevnikova, I. V. Kozlova, T. G. Shapovalova, G. L. Yurenev   +5 more
doaj   +1 more source

Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract

Journal of Experimental Pharmacology, 2021
Agung H Karsono,1 Olivia M Tandrasasmita,1 Guntur Berlian,1 Raymond R Tjandrawinata2,3 1Section of Molecular Pharmacology, Research Innovation and Invention, Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Cikarang, West Java 17550, Indonesia ...
Karsono AH, Tandrasasmita OM, Berlian G, Tjandrawinata RR   +3 more
doaj  

Mutations in Non–Small Cell Lung Cancer: Clinicopathologic Features and Prognostic Implications

Clinical Medicine Insights: Oncology, 2023
Introduction: The associations between the clinical characteristics of non–small cell lung cancer (NSCLC) and mutations in telomerase reverse transcriptase ( TERT ) gene remain unclear.
Liu Yang, Meng Wang, Na Li, Lu-Da Yan, Wen Zhou, Zhi-Qiong Yu, Xiao-Chun Peng, Jun Cai, Yong-Hua Yang   +8 more
doaj   +1 more source

TERT Promoter Mutations in Papillary Thyroid Microcarcinomas [PDF]

, 2015
Small papillary thyroid carcinomas have contributed to the worldwide increased incidence of differentiated thyroid cancer observed over the past decades.
Bruno, Rocco, Casadei, Gianpaolo, Ciarrocchi, Alessia, Costante, Giuseppe, de Biase, Dario, Durante, Cosimo, Eszlinger, Markus, Filetti, Sebastiano, Frasoldati, Andrea, Gandolfi, Greta, Gugnoni, Mila, Paschke, Ralf, Pession, Annalisa, Piana, Simonetta, Ragazzi, Moira, Sancisi, Valentina, Tallini, Giovanni, Torlontano, Massimo, Visani, Michela   +18 more
core   +1 more source

Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis

Frontiers in Bioscience-Landmark
Background: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li, Hua Tao, Yini Wei, Ru Meng, Yushan Li, Lifang Nie, Yu Zhang, Jinjun Chang   +7 more
doaj   +1 more source

Comparison of stabilization by Vitamin E and 2,6-di-tert-butylphenols during polyethylene radio-thermal-oxidation [PDF]

, 2014
This paper reports a compilation of data for PE+Vitamin E and 2,6-di-tert-butylphenols oxidation in radio-thermal ageing. Data unambiguously show that Vitamin E reacts with P° and POO° whereas 2,6-di-tert-butyl phenols only react with POO°.
RICHAUD, Emmanuel
core   +6 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant TERT promoter methylation, but not hot-spot mutations

Epigenetics, 2019
Telomere maintenance is a critical requirement for enabling replicative immortality and tumour development. Here, telomerase expression and activity, telomere length (TL) and potential regulatory factors that can underlie telomerase machinery alterations
Omid Fotouhi, Mehran Ghaderi, Na Wang, Jan Zedenius, Magnus Kjellman, Dawei Xu, C. Christofer Juhlin, Catharina Larsson   +7 more
doaj   +1 more source

Hyperpolarized δ-[1- 13C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma

Scientific Reports, 2023
TERT promoter mutations are a hallmark of glioblastoma (GBM). Accordingly, TERT and GABPB1, a subunit of the upstream mutant TERT promoter transcription factor GABP, are being considered as promising therapeutic targets in GBM.
Noriaki Minami, Donghyun Hong, Celine Taglang, Georgios Batsios, Anne Marie Gillespie, Pavithra Viswanath, Nicholas Stevers, Carter J. Barger, Joseph F. Costello, Sabrina M. Ronen   +9 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source