Given their ubiquitous progressive nature and unfavorable prognosis, interstitial lung diseases (ILD), especially such common variants as idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP), rightly attract considerable attention ...
E. E. Arkhangelskaya +5 more
doaj +1 more source
Background: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li +7 more
doaj +1 more source
Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract
Agung H Karsono,1 Olivia M Tandrasasmita,1 Guntur Berlian,1 Raymond R Tjandrawinata2,3 1Section of Molecular Pharmacology, Research Innovation and Invention, Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Cikarang, West Java 17550, Indonesia ...
Karsono AH +3 more
doaj
Expression of telomerase reverse transcriptase in peripheral T‐cell lymphoma
Telomere length is maintained by the activation of telomerase, which causes continuous cell division and proliferation in many carcinomas. A catalytic reverse transcriptase protein (TERT) encoded by the TERT gene plays a critical role in the activation ...
Fumiko Arakawa +13 more
doaj +1 more source
Total synthesis of an isoflavone C-glycoside: 6-tert-butylpuerarin [PDF]
The first total synthesis of an isoflavone C-glycoside (6-tert-butylpuerarin) using commercially available 4,6-di-tert-butylbenzene-1,3-diol as starting material was achieved in five steps with an overall yield of 2.8%.
Tao Peng (81319) +7 more
core +1 more source
The Role of ATRX and TERT Expressions in Determining Aggressiveness of Neuroblastoma
Objective: Neuroblastoma (NB) is a common childhood tumour, affecting telomerase enzyme activity. Expression of telomerase reverse transcriptase (TERT) protein is crucial for the fuınctioning of telomerase activity, but its association with risk ...
Murat Tuncel +8 more
doaj +1 more source
Mutations in Non–Small Cell Lung Cancer: Clinicopathologic Features and Prognostic Implications
Introduction: The associations between the clinical characteristics of non–small cell lung cancer (NSCLC) and mutations in telomerase reverse transcriptase ( TERT ) gene remain unclear.
Liu Yang +8 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Tert-Butoxide-Mediated Protodeformylation of Tertiary Homobenzaldehydes [PDF]
Tert-butoxide mediates the protodeformylation of tertiary homobenzaldehydes and related compounds at ambient temperature. Both geminal dialkyl and geminal diaryl substituents are tolerated.
Benjamin J., Stokes, Xiao, Cai
core +1 more source
Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms. [PDF]
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though
Alan E Bilsland +6 more
doaj +1 more source

