Results 41 to 50 of about 187,148 (306)

Idiopathic Pulmonary Fibrosis and Hypersensitive Pneumonitis: A Fresh View on The Role of Genetic and Epigenetic Factors in The Development and Course of Diseases

open access: yesАрхивъ внутренней медицины
Given their ubiquitous progressive nature and unfavorable prognosis, interstitial lung diseases (ILD), especially such common variants as idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP), rightly attract considerable attention ...
E. E. Arkhangelskaya   +5 more
doaj   +1 more source

Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis

open access: yesFrontiers in Bioscience-Landmark
Background: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li   +7 more
doaj   +1 more source

Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract

open access: yesJournal of Experimental Pharmacology, 2021
Agung H Karsono,1 Olivia M Tandrasasmita,1 Guntur Berlian,1 Raymond R Tjandrawinata2,3 1Section of Molecular Pharmacology, Research Innovation and Invention, Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Cikarang, West Java 17550, Indonesia ...
Karsono AH   +3 more
doaj  

Expression of telomerase reverse transcriptase in peripheral T‐cell lymphoma

open access: yesCancer Medicine, 2021
Telomere length is maintained by the activation of telomerase, which causes continuous cell division and proliferation in many carcinomas. A catalytic reverse transcriptase protein (TERT) encoded by the TERT gene plays a critical role in the activation ...
Fumiko Arakawa   +13 more
doaj   +1 more source

Total synthesis of an isoflavone C-glycoside: 6-tert-butylpuerarin [PDF]

open access: yes, 2017
The first total synthesis of an isoflavone C-glycoside (6-tert-butylpuerarin) using commercially available 4,6-di-tert-butylbenzene-1,3-diol as starting material was achieved in five steps with an overall yield of 2.8%.
Tao Peng (81319)   +7 more
core   +1 more source

The Role of ATRX and TERT Expressions in Determining Aggressiveness of Neuroblastoma

open access: yesJournal of Behçet Uz Children's Hospital
Objective: Neuroblastoma (NB) is a common childhood tumour, affecting telomerase enzyme activity. Expression of telomerase reverse transcriptase (TERT) protein is crucial for the fuınctioning of telomerase activity, but its association with risk ...
Murat Tuncel   +8 more
doaj   +1 more source

Mutations in Non–Small Cell Lung Cancer: Clinicopathologic Features and Prognostic Implications

open access: yesClinical Medicine Insights: Oncology, 2023
Introduction: The associations between the clinical characteristics of non–small cell lung cancer (NSCLC) and mutations in telomerase reverse transcriptase ( TERT ) gene remain unclear.
Liu Yang   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Tert-Butoxide-Mediated Protodeformylation of Tertiary Homobenzaldehydes [PDF]

open access: yes, 2021
Tert-butoxide mediates the protodeformylation of tertiary homobenzaldehydes and related compounds at ambient temperature. Both geminal dialkyl and geminal diaryl substituents are tolerated.
Benjamin J., Stokes, Xiao, Cai
core   +1 more source

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms. [PDF]

open access: yesPLoS Computational Biology, 2014
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though
Alan E Bilsland   +6 more
doaj   +1 more source

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