Results 51 to 60 of about 367,883 (311)

The Role of ATRX and TERT Expressions in Determining Aggressiveness of Neuroblastoma

Journal of Behçet Uz Children's Hospital
Objective: Neuroblastoma (NB) is a common childhood tumour, affecting telomerase enzyme activity. Expression of telomerase reverse transcriptase (TERT) protein is crucial for the fuınctioning of telomerase activity, but its association with risk ...
Murat Tuncel, Selen Kum Özşengezer, Gamze Sanlav, Deniz Kızmazoğlu, Safiye Aktaş, Zekiye Altun, Tekincan Çağrı Aktaş, Erdener Özer, Nur Olgun   +8 more
doaj   +1 more source

Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers

Molecular Oncology, 2020
Telomerase reverse transcriptase (TERT) is pathologically expressed in the vast majority of human cancers, but the epigenetic regulation of its expression is only beginning to be understood.
Teisha J. Rowland, Andrew J. Bonham, Thomas R. Cech   +2 more
doaj   +1 more source

Structural features of alkylphenolic chemicals associated with estrogenic activity [PDF]

, 1997
The ability of certain man-made chemicals to mimic the effects of natural steroid hormones and their potential to disrupt the delicate balance of the endocrine system in animals are of increasing concern.
Routledge, EJ, Sumpter, JP
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma

Cell Death and Disease, 2020
Hepatocellular carcinoma (HCC) has a high mortality rate and lacks an effective therapeutic target. Elevated expression of human telomerase reverse transcriptase (TERT) is an important hallmark in cancers, but the mechanism by which TERT is activated ...
Wenbin Li, Yue Yan, Zongheng Zheng, Qiaohua Zhu, Qian Long, Silei Sui, Meihua Luo, Miao Chen, Yizhuo Li, Yijun Hua, Wuguo Deng, Renchun Lai, Liren Li   +12 more
doaj   +1 more source

Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness

Molecular Oncology, 2021
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described.
Manuel Bernabé‐García, Elena Martínez‐Balsalobre, Diana García‐Moreno, Jesús García‐Castillo, Beatriz Revilla‐Nuin, Elena Blanco‐Alcaina, Victoriano Mulero, Francisca Alcaraz‐Pérez, María L. Cayuela   +8 more
doaj   +1 more source

Double and triple calix[4]arenis connected via the oxygen functions [PDF]

, 1990
New macrocyclic molecules are described containing two or three p-tert-butylcalix[4]arene subunits connected via their oxygen atoms. These macrocycles are available by two general methods which are capable of producing assemblies with bridges of varying ...
Böhmer, Volker, Kraft, Dagmar, Loon, Jan-Dirk van, McKervey, M. Anthony, Owens, Michael, Reinhoudt, David N., Verboom, Willem, Vogt, Walter   +7 more
core   +4 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

A telomerase with novel non-canonical roles: TERT controls cellular aggregation and tissue size in Dictyostelium.

PLoS Genetics, 2019
Telomerase, particularly its main subunit, the reverse transcriptase, TERT, prevents DNA erosion during eukaryotic chromosomal replication, but also has poorly understood non-canonical functions. Here, in the model social amoeba Dictyostelium discoideum,
Nasna Nassir, Geoffrey J Hyde, Ramamurthy Baskar   +2 more
doaj   +1 more source

Isolation and characterisation of 2-Tert-butyl-8-hydroxyquinoline as a crystalline solid and its blue fluorescent Li complex [PDF]

, 2014
Copyright © 2014 Poopathy Kathirgamanathan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is ...
Blake, AJ, Kathirgamanathan, P, Ravichandran, S, Surendrakumar, S   +3 more
core   +5 more sources