Results 51 to 60 of about 187,148 (306)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Remarkable Transformation of 2,4,6-Tri-tert-butyl-1,3,5-triphosphabenzene into the 2,4,5-Tri-tert -butyl-1,3-diphosphacyclopentadienide Anion [PDF]

, 2000
In an unprecedented reaction, the reduction of 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene over a potassium mirror in toluene resulted in the abstraction of P3- and generation of the 2,4,5-tri-tert-butyl-1,3-diphosphacyclopentadienide anion, P2C3Bu3t ...
D James Wilson (16062635), Geoff Cloke (4460350), Peter B Hitchcock (16057433), John F Nixon (16060778)   +3 more
core   +2 more sources

Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant TERT promoter methylation, but not hot-spot mutations

Epigenetics, 2019
Telomere maintenance is a critical requirement for enabling replicative immortality and tumour development. Here, telomerase expression and activity, telomere length (TL) and potential regulatory factors that can underlie telomerase machinery alterations
Omid Fotouhi, Mehran Ghaderi, Na Wang, Jan Zedenius, Magnus Kjellman, Dawei Xu, C. Christofer Juhlin, Catharina Larsson   +7 more
doaj   +1 more source

Hyperpolarized δ-[1- 13C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma

Scientific Reports, 2023
TERT promoter mutations are a hallmark of glioblastoma (GBM). Accordingly, TERT and GABPB1, a subunit of the upstream mutant TERT promoter transcription factor GABP, are being considered as promising therapeutic targets in GBM.
Noriaki Minami, Donghyun Hong, Celine Taglang, Georgios Batsios, Anne Marie Gillespie, Pavithra Viswanath, Nicholas Stevers, Carter J. Barger, Joseph F. Costello, Sabrina M. Ronen   +9 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers

Molecular Oncology, 2020
Telomerase reverse transcriptase (TERT) is pathologically expressed in the vast majority of human cancers, but the epigenetic regulation of its expression is only beginning to be understood.
Teisha J. Rowland, Andrew J. Bonham, Thomas R. Cech   +2 more
doaj   +1 more source

Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness

Molecular Oncology, 2021
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described.
Manuel Bernabé‐García, Elena Martínez‐Balsalobre, Diana García‐Moreno, Jesús García‐Castillo, Beatriz Revilla‐Nuin, Elena Blanco‐Alcaina, Victoriano Mulero, Francisca Alcaraz‐Pérez, María L. Cayuela   +8 more
doaj   +1 more source

Über die Reaktion von tert-Butyl(tert-butylimino)phosphan mit tert-Butyl-(tert-butylimino)boran

, 2012
Contrary to the [2 + 2] cycloaddition reaction of aminoiminophosphanes with iminoboranes, the title compounds react to yield the heterocyclic products 7 and 9, the structures of which were determined by means of spectroscopic methods and, in the case of 9, additionally by X-ray structural analysis.
Gudat, Dietrich, Niecke, Edgar, Nieger, Martin, Paetzold, Peter   +3 more
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source