Results 61 to 70 of about 130,112 (263)

Oncolytic Adenovirus RCA-TERT-Ad35 Carrying Human Telomerase Reverse Transcriptase Promoter Targets Breast Cancer Stem Cells

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the role of oncolytic adenovirus RCA-TERT-Ad35 carrying human telomerase reverse transcriptase promoter in targeting breast cancer stem cells.
WANG Weichuan, CHEN Lulu, QUAN Xianglan, LI Ying, JIN Yongmin, JIN Wenbiao, YU Kexin, ZHANG Songnan   +7 more
doaj   +1 more source

Packed Hydrogel Microfibers as Scaffolds Supporting Dynamic Cellular Behavior and Biomaterial Inks in 3D Printing

Advanced Healthcare Materials, EarlyView.
Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal, Remington M. Martinez, Georgia T. Helein, Montserrath G. Ibarra Rivera, Rodolfo Martinez Jr., Jenna L. Sumey, Steven R. Caliari, Christopher B. Highley   +7 more
wiley   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Pan-cancer experimental characteristic of human transcriptional patterns connected with telomerase reverse transcriptase (TERT) gene expression status

Frontiers in Genetics
The TERT gene encodes the reverse transcriptase subunit of telomerase and is normally transcriptionally suppressed in differentiated human cells but reactivated in cancers where its expression is frequently associated with poor survival prognosis.
Aleksey Drobyshev, Aleksey Drobyshev, Alexander Modestov, Maria Suntsova, Maria Suntsova, Elena Poddubskaya, Elena Poddubskaya, Alexander Seryakov, Aleksey Moisseev, Maksim Sorokin, Maksim Sorokin, Victor Tkachev, Galina Zakharova, Aleksander Simonov, Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Anton Buzdin, Anton Buzdin, Anton Buzdin, Anton Buzdin   +20 more
doaj   +1 more source

Expression of the Reverse Transcriptase Domain of Telomerase Reverse Transcriptase Induces Lytic Cellular Response in DNA-Immunized Mice and Limits Tumorigenic and Metastatic Potential of Murine Adenocarcinoma 4T1 Cells

Vaccines, 2020
Telomerase reverse transcriptase (TERT) is a classic tumor-associated antigen overexpressed in majority of tumors. Several TERT-based cancer vaccines are currently in clinical trials, but immune correlates of their antitumor activity remain largely ...
Juris Jansons, Ekaterina Bayurova, Dace Skrastina, Alisa Kurlanda, Ilze Fridrihsone, Dmitry Kostyushev, Anastasia Kostyusheva, Alexander Artyuhov, Erdem Dashinimaev, Darya Avdoshina, Alla Kondrashova, Vladimir Valuev-Elliston, Oleg Latyshev, Olesja Eliseeva, Stefan Petkov, Maxim Abakumov, Laura Hippe, Irina Kholodnyuk, Elizaveta Starodubova, Tatiana Gorodnicheva, Alexander Ivanov, Ilya Gordeychuk, Maria Isaguliants   +22 more
doaj   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

TERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer

Cancer Cell International
Background DNA hypermethylation and hotspot mutations were frequently observed in the upstream and core promoter of telomerase reverse transcriptase (TERT), respectively, and they were associated with increased TERT expression and adverse clinical ...
Shiyong Li, Guanghui Hu, Yulu Chen, Ye Sang, Qin Tang, Rengyun Liu   +5 more
doaj   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Ferroelectric Quantum Dots for Retinomorphic In‐Sensor Computing

Advanced Materials, EarlyView.
This work has provided a protocol for fabricating retinomorphic phototransistors by integrating ferroelectric ligands with quantum dots. The resulting device combines ferroelectricity, optical responsiveness, and low‐power operation to enable adaptive signal amplification and high recognition accuracy under low‐light conditions, while supporting ...
Tingyu Long, Huanyu Zhou, Jaewan Ko, Hongwei Tan, Jaemin Lim, Yanfei Zhao, Daehan Kang, Eojin Yoon, Gyeong‐Tak Go, Somin Kim, Seung‐Woo Lee, Chan‐Yul Park, Hyojun Choi, Hyeran Kim, Hyung Joong Yun, Sung Hyuk Park, Kwan Sik Park, Jeong Woo Park, Mungeun Kim, Yong Soo Cho, Ho Won Jang, Wenqiang Yang, Min Hyuk Park, Wan Ki Bae, Sebastiaan van Dijken, Joona Bang, Tae‐Woo Lee   +26 more
wiley   +1 more source

Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development

Stem Cell Reports, 2017
Summary: The molecular mechanism of memory formation remains a mystery. Here, we show that TERT, the catalytic subunit of telomerase, gene knockout (Tert−/−) causes extremely poor ability in spatial memory formation.
Qi-Gang Zhou, Meng-Ying Liu, Han-Woong Lee, Fuyuki Ishikawa, Sushil Devkota, Xin-Ru Shen, Xin Jin, Hai-Yin Wu, Zhigang Liu, Xiao Liu, Xun Jin, Hai-Hui Zhou, Eun Jeoung Ro, Jing Zhang, Yu Zhang, Yu-Hui Lin, Hoonkyo Suh, Dong-Ya Zhu   +17 more
doaj   +1 more source