Results 81 to 90 of about 203,484 (292)
Frontiers in GeneticsThe TERT gene encodes the reverse transcriptase subunit of telomerase and is normally transcriptionally suppressed in differentiated human cells but reactivated in cancers where its expression is frequently associated with poor survival prognosis.
Aleksey Drobyshev +20 more
doaj +1 more source
Vaccines, 2020 Telomerase reverse transcriptase (TERT) is a classic tumor-associated antigen overexpressed in majority of tumors. Several TERT-based cancer vaccines are currently in clinical trials, but immune correlates of their antitumor activity remain largely ...
Juris Jansons +22 more
doaj +1 more source
TERT promoter mutations in soft tissue sarcomas
, 2016 Introduction Oncogenic hotspot mutations in the promoter region of the TERT gene have been identified in several cancer types as being associated with a worse outcome.
Scapulatempo-Neto, Cristovam +8 more
core +1 more source
Phase Engineering of Atomically Precise Nanoclusters (APNCs) of Gold and Beyond
Advanced Materials, EarlyView.Engineering the structural phase of materials is of paramount importance for both fundamental research and practical applications. In this Review, we summarize the recent progress in controlling the phases of atomically precise nanoclusters (APNCs) of gold, silver and copper, as well as bimetallic systems. The phase‐enabled material properties of APNCs
Yitong Wang +4 more
wiley +1 more source
Cancer Cell InternationalBackground DNA hypermethylation and hotspot mutations were frequently observed in the upstream and core promoter of telomerase reverse transcriptase (TERT), respectively, and they were associated with increased TERT expression and adverse clinical ...
Shiyong Li +5 more
doaj +1 more source
Engineering Metal‐Pocket Cooperativity in Single‐Atom COF Nanozymes for Selective Cascade Catalysis
Advanced Materials, EarlyView.A multilevel programming strategy is developed to engineer single‐atom COF nanozymes with tunable metal centers and chiral pockets inspired by heme–pocket cooperativity. This approach enables controlled metal–pocket interplay for asymmetric cascade catalysis, delivering high activity, selectivity, and recyclability in an asymmetric oxidation–aldol ...
Ziping Li +7 more
wiley +1 more source
Metastable Polymers for Circular 3D Printing
Advanced Materials, EarlyView.3D‐printed polymers are usually permanent and hard to recycle. Here, metastable polymers are designed to fall apart on demand. A chemical trigger unzips the printed material back into its original building blocks within minutes at room temperature.
Johannes Markhart +2 more
wiley +1 more source
Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development
Stem Cell Reports, 2017 Summary: The molecular mechanism of memory formation remains a mystery. Here, we show that TERT, the catalytic subunit of telomerase, gene knockout (Tert−/−) causes extremely poor ability in spatial memory formation.
Qi-Gang Zhou +17 more
doaj +1 more source
, 2020 P-tert-butyldihomooxacalix[4]arene is a well-known calix[4]arene analog in which one CH2 bridge is replaced by one -O- group. Thus, dihomooxacalix[4]arene has a slightly larger cavity than that of calix[4]arene and usually possesses a more flexible cone ...
Runmiao Zhang (7023848) +4 more
core +1 more source
Programmable Carrier‐Free All‐Enzyme Beads for Modular Continuous‐Flow Biocatalysis
Advanced Materials, EarlyView.Genetically encoded enzyme building blocks self‐assemble into monodisperse, carrier‐free protein beads via a droplet‐based formulation strategy. These programmable catalytic particles enable modular continuous‐flow biocatalysis, from single‐enzyme reactions to multi‐enzyme cascades and bead–bead coupled reactor systems.
Jennifer Kühne +12 more
wiley +1 more source