Results 1 to 10 of about 114,134 (356)
At short telomeres Tel1 directs early replication and phosphorylates Rif1. [PDF]
PLoS Genetics, 2014 The replication time of Saccharomyces cerevisiae telomeres responds to TG1-3 repeat length, with telomeres of normal length replicating late during S phase and short telomeres replicating early.
Akila Sridhar +2 more
doaj +14 more sources
Early differential responses elicited by BRAFV600E in adult mouse models
Cell Death and Disease, 2022 The BRAF gene is frequently mutated in cancer. The most common genetic mutation is a single nucleotide transition which gives rise to a constitutively active BRAF kinase (BRAFV600E) which in turn sustains continuous cell proliferation.
Giuseppe Bosso +5 more
doaj +1 more source
Nature Communications, 2022 Telomere dysfunction induced by TRF1 depletion in fibroblasts, club and basal cells did not lead to interstitial lung fibrosis, underscoring alveolar type II cells as the relevant cell type in pulmonary fibrosis.
Sergio Piñeiro-Hermida +7 more
doaj +1 more source
The analysis of pendolino (peo) mutants reveals differences in the fusigenic potential among Drosophila telomeres [PDF]
, 2015 Drosophila telomeres are sequence-independent structures that are maintained by transposition to chromosome ends of three specialized retroelements (HeT-A, TART and TAHRE; collectively designated as HTT) rather than telomerase activity. Fly telomeres are
Burla, Romina +8 more
core +7 more sources
Behind Base J: The Roles of JBP1 and JBP2 on Trypanosomatids
Pathogens, 2023 β-D-glucopyranosyloxymethiluracil (Base J) is a modified thymidine base found in kinetoplastids and some related organisms. Interestingly, Base J distribution into the genome can vary depending on the organism and its life stage. Base J is reported to be
Luiz Henrique de Castro Assis +2 more
doaj +1 more source
Cell Cycle, Telomeres, and Telomerase in Leishmania spp.: What Do We Know So Far?
Cells, 2021 Leishmaniases belong to the inglorious group of neglected tropical diseases, presenting different degrees of manifestations severity. It is caused by the transmission of more than 20 species of parasites of the Leishmania genus. Nevertheless, the disease
Luiz H. C. Assis +10 more
doaj +1 more source
The mTOR pathway is necessary for survival of mice with short telomeres
Nature Communications, 2020 Telomerase deficiency leads to age-related diseases and shortened lifespan, while inhibition of the mTOR pathway delays aging. Here, the authors show that inhibition of mTORC1 signaling shortens the lifespan of telomerase deficient mice.
Iole Ferrara-Romeo +10 more
doaj +1 more source
Mammalian telomeres and their partnership with lamins [PDF]
, 2016 Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA +2 more
core +1 more source
eLife, 2019 The mechanisms that regulate pluripotency are still largely unknown. Here, we show that Telomere Repeat Binding Factor 1 (TRF1), a component of the shelterin complex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to
Rosa María Marión +7 more
doaj +1 more source
Assessing the Epigenetic Status of Human Telomeres [PDF]
, 2019 The epigenetic modifications of human telomeres play a relevant role in telomere functions and cell proliferation. Therefore, their study is becoming an issue of major interest.
Vaquero Sedas, María Isabel +1 more
core +1 more source