Results 31 to 40 of about 66,266 (300)
The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. [PDF]
PLoS Genetics, 2015 Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB).
Jane A Phillips +3 more
doaj +1 more source
XPF activates break-induced telomere synthesis
Nature Communications, 2022 Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend ...
Chia-Yu Guh +15 more
doaj +1 more source
Defective Artemis causes mild telomere dysfunction [PDF]
, 2010 This article has been made available through the Brunel Open Access Publishing Fund.Background: Repair of DNA double strand breaks by non-homologous end joining (NHEJ) requires several proteins including Ku, DNA-PKcs, Artemis, XRCC4, Ligase IV and XLF ...
Slijepcevic, P +3 more
core +1 more source
Cytogenetic and Genome Research, 2013 In fishes, as in other vertebrate species, the DNA component of the telomeres consists of the tandemly repeated TTAGGG motif. The length of the telomeric arrays in fishes ranges from 2 to 25 kb and shortens with age in some of the species. To date, chromosomal distribution of the telomeric DNA sequences has been examined in approximately 80 fish ...
openaire +2 more sources
Multiple cancer pathways regulate telomere protection
EMBO Molecular Medicine, 2019 Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cancer. In addition,
Leire Bejarano +9 more
doaj +1 more source
Haematologica, 2015 Aplastic anemia is a rare but life-threatening disorder characterized by cytopenia in at least two of the three blood lineages. A frequent feature of patients with aplastic anemia is that they have shorter telomeres than those of age-matched controls ...
Christian Bär +3 more
doaj +1 more source
Genes, 2022 Telomeres are essential structures formed from satellite DNA repeats at the ends of chromosomes in most eukaryotes. Satellite DNA repeat sequences are useful markers for karyotyping, but have a more enigmatic role in the eukaryotic cell. Much work has been done to investigate the structure and arrangement of repetitive DNA elements in classical models ...
Leon P. Jenner +3 more
openaire +2 more sources
The Rate of Increase of Short Telomeres Predicts Longevity in Mammals
Cell Reports, 2012 Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telomere maintenance. Normal populations of humans and mice present high interindividual variation in telomere length, but it is unknown whether this is ...
Elsa Vera +4 more
doaj +1 more source
Structural basis for Rap1-Rif1-Rif2 assembly : insights into budding yeast telomere architecture and functions [PDF]
, 2012 Telomeres form the ends of eukaryotic linear chromosomes and are composed of specialized nucleoprotein complexes. They have been the subject of intense investigation over several decades, as telomere dysfunction has been associated with genome ...
Tianlai, Shi
core +1 more source
EMBO Molecular Medicine, 2012 A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity.
Bruno Bernardes de Jesus +6 more
doaj +1 more source