Results 11 to 20 of about 66,266 (300)
Current Opinion in Cell Biology, 1991 Telomeres are essential for chromosome stability and replication. Maintaining a balance between telomere shortening and lengthening is essential for cell viability.
Greider, C. W.
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Telomeric RNAs are essential to maintain telomeres [PDF]
Nature Communications, 2016 The telomeric long-non coding RNA, TERRA, has been proposed in the past to modulate different telomeric functions based on in vitrostudies. Here the authors show, using a genetic deletion approach, that TERRA is transcribed from the 20q subtelomere and ...
Juan José Montero +3 more
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Telomeric recombination induced by dysfunctional telomeres
Molecular Biology of the Cell, 2011 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets.
Chantal Autexier, Marie Eve Brault
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Long telomeres: too much of a good thing [PDF]
Biomolecular Concepts, 2012 Telomeres, the physical ends of linear eukaryotic chromosomes, protect chromosome ends from end fusions and degradation. Telomere length is tightly regulated to ensure that telomeres are neither too short nor too long.
Chang Michael
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Telomeres, a Busy Platform for Cell Signaling [PDF]
Frontiers in Oncology, 2013 Telomeres are the terminal structures at the ends of linear chromosomes that represent a solution to the end replication problem. Specific binding of the six-protein subunit complex shelterin to telomeric, repetitive TTAGGG DNA sequences contributes to ...
Laura eGardano +4 more
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Retrotransposons and Telomeres
Biochemistry (Moscow), 2023 Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle.
Alla I, Kalmykova, Olesya A, Sokolova
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A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs [PDF]
The EMBO Journal, 2009 Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it has become apparent that epigenetic regulation of the telomeric chromatin template critically impacts on telomere function and telomere-length homeostasis from yeast to man.
SCHOEFTNER, Stefan, Blasco Maria, A.
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Telomeres and Telomere Length: A General Overview [PDF]
Cancers, 2020 Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas +2 more
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The Tail of the Telomere [PDF]
Journal of the American Chemical Society, 2008 The structure of a higher-order G-quadruplex structure for human telomeric DNA is presented. The structure was determined by a novel integrated approach in which molecular dynamics simulations were used to produce a stable structure, from which specific experimentally accessible properties were predicted.
PETRACCONE, LUIGI +2 more
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Telomeres in Evolution and Development from Biosemiotic Perspective [PDF]
, 2007 Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
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