Results 11 to 20 of about 114,134 (356)
Telomeric RNAs are essential to maintain telomeres [PDF]
Nature Communications, 2016 The telomeric long-non coding RNA, TERRA, has been proposed in the past to modulate different telomeric functions based on in vitrostudies. Here the authors show, using a genetic deletion approach, that TERRA is transcribed from the 20q subtelomere and ...
Juan José Montero +3 more
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The human telomeric proteome during telomere replication [PDF]
Nucleic Acids Research, 2020 Abstract Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of ...
Chih-Yi Gabriela Lin +5 more
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EMBO reports, 2002 Telomeres are protein–DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric
Daniela, Rhodes +4 more
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A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs [PDF]
The EMBO Journal, 2009 Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it has become apparent that epigenetic regulation of the telomeric chromatin template critically impacts on telomere function and telomere-length homeostasis from yeast to man.
SCHOEFTNER, Stefan, Blasco Maria, A.
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Retrotransposons and Telomeres
Biochemistry (Moscow), 2023 Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle. Piwi proteins and Piwi-interacting RNAs (piRNAs) are key elements of the anti-transposon
Alla I, Kalmykova, Olesya A, Sokolova
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DNA methylation at tobacco telomeric sequences [PDF]
, 2011 Majerová et al. (Plant Mol Biol, 2011) have recently reported that a considerable fraction of cytosines at tobacco telomeres is methylated. Although the data presented in this report indicate that tobacco telomeric sequences undergo certain levels of DNA
Vaquero Sedas, María Isabel +1 more
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Telomeres and Telomere Length: A General Overview [PDF]
Cancers, 2020 Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas +2 more
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Increase in short telomeres during the third trimester in human placenta
PLoS ONE, 2022 An increase in telomere shortening in gestational tissues has been proposed as a mechanism involved in the timing for the initiation of parturition. An increase in very short telomeres with increasing gestational age has been observed in mice; this study
Paula K. Edelson +5 more
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Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation
Cell Reports, 2014 Sox4 expression is restricted in mammals to embryonic structures and some adult tissues, such as lymphoid organs, pancreas, intestine, and skin. During embryogenesis, Sox4 regulates mesenchymal and neural progenitor survival, as well as lymphocyte and ...
Miguel Foronda +7 more
doaj +1 more source
The relationship of telomere length to baseline corticosterone levels in nestlings of an altricial passerine bird in natural populations. [PDF]
, 2016 BackgroundEnvironmental stressors increase the secretion of glucocorticoids that in turn can shorten telomeres via oxidative damage. Modification of telomere length, as a result of adversity faced early in life, can modify an individual's phenotype ...
Guerrero, Claudia Jimena +4 more
core +6 more sources