Results 11 to 20 of about 59,567 (314)

Telomeric RNAs are essential to maintain telomeres [PDF]

Nature Communications, 2016
The telomeric long-non coding RNA, TERRA, has been proposed in the past to modulate different telomeric functions based on in vitrostudies. Here the authors show, using a genetic deletion approach, that TERRA is transcribed from the 20q subtelomere and ...
Juan José Montero, Isabel López de Silanes, Osvaldo Graña, Maria A. Blasco   +3 more
doaj   +4 more sources

Telomeres

Current Opinion in Cell Biology, 1991
Telomeres are essential for chromosome stability and replication. Maintaining a balance between telomere shortening and lengthening is essential for cell viability. Recent work on telomeres from yeast, Drosophila and mammals, and on telomerase has provided insight into the mechanisms of both the shortening and lengthening processes.
Greider, C. W.
openaire   +3 more sources

Long telomeres: too much of a good thing [PDF]

Biomolecular Concepts, 2012
Telomeres, the physical ends of linear eukaryotic chromosomes, protect chromosome ends from end fusions and degradation. Telomere length is tightly regulated to ensure that telomeres are neither too short nor too long.
Chang Michael
doaj   +2 more sources

Retrotransposons and Telomeres

Biochemistry (Moscow), 2023
Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle.
Alla I, Kalmykova, Olesya A, Sokolova
openaire   +2 more sources

A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs [PDF]

The EMBO Journal, 2009
Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it has become apparent that epigenetic regulation of the telomeric chromatin template critically impacts on telomere function and telomere-length homeostasis from yeast to man.
SCHOEFTNER, Stefan, Blasco Maria, A.
openaire   +4 more sources

Telomeres and Telomere Length: A General Overview [PDF]

Cancers, 2020
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas, Sivaramakrishna Rachakonda, Rajiv Kumar   +2 more
openaire   +2 more sources

The Tail of the Telomere [PDF]

Journal of the American Chemical Society, 2008
The structure of a higher-order G-quadruplex structure for human telomeric DNA is presented. The structure was determined by a novel integrated approach in which molecular dynamics simulations were used to produce a stable structure, from which specific experimentally accessible properties were predicted.
PETRACCONE, LUIGI, John O. Trent, Jonathan B. Chaires   +2 more
openaire   +4 more sources

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]

, 2012
© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Marija Guc-Scekic, Juan P Trujillo, Maja Zivkovic, Gordana Joksic, Predrag Slijepcevic, Slijepcevic, P, Trujillo, JP, Surrallés i Calonge, Jordi, Petrovic, S, Zivkovic, Maja, Joksic, I, Trujillo Quintero, Juan Pablo, Joksic, G, Jordi Surralles, Aleksandra Stankovic, Vujic, D, Zivkovic, M, Vujic, Dragana, Joksic, Gordana, Andreja Leskovac, Joksic, Ivana, Surralles, J, Guc-Scekic, Marija, Maryam Ojani, Ojani, M, Ojani, Maryam, Dragana Vujic, Slijepcevic, Pedrag, Petrovic, Sandra, Sandra Petrovic, Guc-Scekic, M, Stankovic, A, Stankovic, Aleksandra, Leskovac, Andreja, Ivana Joksic, Leskovac, A   +35 more
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TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. [PDF]

, 2011
Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to ...
Tomlinson, IP, A M Jones, Beggs, A. D., Jones, A. M., M Walker, Jones, A.M., Dunlop, MG, Beggs, A.D., Tenesa, A., A D Beggs, Kerr, D, A Zauber, A Tenesa, Hodgson, S. V., Walker, M., M Bertagnolli, R Midgley, Carvajal-Carmona, L, Dunlop, Malcolm, Tenesa, Albert, Tenesa, A, Kerr, D., Jones, AM, Beggs, AD, M G Dunlop, Kerr, David, Jones, A M, Tomlinson, IPM, Carvajal-Carmona, L., Campbell, H.; id_orcid, Tomlinson, I P M, S Ballereau, Tomlinson, I. P. M., Zauber, A., S V Hodgson, Campbell, H, H Campbell, Farrington, S., Hodgson, SV, Ballereau, S., Campbell, H., Midgley, Rachel, Walker, M, S Farrington, I P M Tomlinson, Dunlop, M G, K Howarth, Farrington, S.; id_orcid, Howarth, K., Ballereau, S, Hodgson, S.V., Bertagnolli, M., Tomlinson, I.P., Beggs, A D; id_orcid, Midgley, R., D Kerr, Bertagnolli, M, L Carvajal-Carmona, Hodgson, S V, Dunlop, M. G., Midgley, R, Zauber, A, Howarth, K, Farrington, S   +63 more
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Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]

, 2011
Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco, Maria A Blasco, Marión, Rosa M., Ortega Sagrario, Marión Rosa M., Schotta Gunnar, Blasco Maria A., Schotta, Gunnar, Rosa M. Marión, Blasco, Maria A., Gunnar Schotta, Sagrario Ortega, Rosa M Marión, Ortega, Sagrario   +13 more
core   +1 more source