Results 21 to 30 of about 114,134 (356)
Nature Communications, 2016 Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing ...
Elisa Varela +4 more
doaj +1 more source
Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease [PDF]
, 2014 © 2014 John Wiley & Sons Ltd. Defining the prognosis of individual cancer sufferers remains a significant clinical challenge. Here we assessed the ability of high-resolution single telomere length analysis (STELA), combined with an experimentally ...
Allan, James M. +14 more
core +1 more source
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]
, 2012 Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Bauwens, Serge +10 more
core +9 more sources
Mice with hyper-long telomeres show less metabolic aging and longer lifespans
Nature Communications, 2019 Telomere shortening is associated with aging. Here the authors analyze mice with hyperlong telomeres and demonstrate that longer telomeres than normal have beneficial effects such as delayed metabolic aging, increased longevity and less incidence of ...
Miguel A. Muñoz-Lorente +2 more
doaj +1 more source
F1000Research, 2016 Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging.
Christian Bär, Maria A. Blasco
doaj +1 more source
The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. [PDF]
PLoS Genetics, 2015 Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB).
Jane A Phillips +3 more
doaj +1 more source
Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids. [PDF]
, 2017 DNA:RNA hybrids, nucleic acid structures with diverse physiological functions, can disrupt genome integrity when dysregulated. Human telomeres were shown to form hybrids with the lncRNA TERRA, yet the formation and distribution of these hybrids among ...
Chédin, Frédéric +9 more
core +1 more source
Testing three hypotheses about effects of sensitive-insensitive parenting on telomeres. [PDF]
, 2020 Telomeres are the protective DNA-protein sequences appearing at the ends of chromosomes; they shorten with each cell division and are considered a biomarker of aging.
Beijers, Roseriet +6 more
core +1 more source
XPF activates break-induced telomere synthesis
Nature Communications, 2022 Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend ...
Chia-Yu Guh +15 more
doaj +1 more source
Telomere-driven diseases and telomere-targeting therapies [PDF]
Journal of Cell Biology, 2017 Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short telomeres block the proliferative capacity of stem cells, affecting their potential to regenerate tissues, and trigger the development of age-associated diseases. Mutations in
Paula Martínez, Maria A. Blasco
openaire +3 more sources