Results 21 to 30 of about 66,266 (300)

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]

, 2012
© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Marija Guc-Scekic, Juan P Trujillo, Maja Zivkovic, Gordana Joksic, Predrag Slijepcevic, Slijepcevic, P, Trujillo, JP, Petrovic, S, Zivkovic, Maja, Joksic, I, Trujillo Quintero, Juan Pablo, Joksic, G, Jordi Surralles, Aleksandra Stankovic, Vujic, D, Zivkovic, M, Vujic, Dragana, Joksic, Gordana, Andreja Leskovac, Joksic, Ivana, Surralles, J, Guc-Scekic, Marija, Maryam Ojani, Ojani, M, Ojani, Maryam, Dragana Vujic, Slijepcevic, Pedrag, Petrovic, Sandra, Sandra Petrovic, Guc-Scekic, M, Stankovic, A, Stankovic, Aleksandra, Leskovac, Andreja, Ivana Joksic, Leskovac, A, Surralles, Jordi   +35 more
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Analysis of telomere maintenance in artemis defective human cell lines [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomeres are physical ends of chromosomes consisting of (TTAGGG)n DNA sequence and a specialized set of proteins that protect chromosomal ends from ...
Yasaei, Hemad
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TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. [PDF]

, 2011
Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to ...
Tomlinson, IP, A M Jones, Beggs, A. D., Jones, A. M., M Walker, Jones, A.M., Dunlop, MG, Beggs, A.D., Tenesa, A., A D Beggs, Kerr, D, A Zauber, A Tenesa, Hodgson, S. V., Walker, M., M Bertagnolli, R Midgley, Carvajal-Carmona, L, Dunlop, Malcolm, Tenesa, Albert, Tenesa, A, Kerr, D., Jones, AM, Beggs, AD, M G Dunlop, Jones, A M, Tomlinson, IPM, Carvajal-Carmona, L., Campbell, H.; id_orcid, Tomlinson, I P M, S Ballereau, Tomlinson, I. P. M., Zauber, A., S V Hodgson, Campbell, H, H Campbell, Farrington, S., Hodgson, SV, Ballereau, S., Campbell, H., Walker, M, S Farrington, I P M Tomlinson, Dunlop, M G, K Howarth, Farrington, S.; id_orcid, Howarth, K., Ballereau, S, Hodgson, S.V., Bertagnolli, M., Tomlinson, I.P., Beggs, A D; id_orcid, Midgley, R., D Kerr, Bertagnolli, M, L Carvajal-Carmona, Hodgson, S V, Dunlop, M. G., Midgley, R, Zauber, A, Howarth, K, Farrington, S   +61 more
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The human telomeric proteome during telomere replication [PDF]

Nucleic Acids Research, 2020
Abstract Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of ...
Chih-Yi Gabriela Lin, Anna Christina Näger, Thomas Lunardi, Aleksandra Vančevska, Gérald Lossaint, Joachim Lingner   +5 more
openaire   +3 more sources

Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells [PDF]

, 2011
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Sapir et al.Background: Recent studies suggest that BRCA2 affects telomere maintenance.
Slijepcevic, P, Yaghoub Gozaly-Chianea, Sainu Ravindran, Ravindran, S, Yasaei, H, Ester Sapir, Predrag Slijepcevic, Suliman Al-Wahiby, Hemad Yasaei, Gozaly-Chianea, Y, Sapir, E, Al-Wahiby, S   +11 more
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Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]

, 2010
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
J. Rai, Rai, J., S. Turner, Wong, H. P., Hartshorne, Geraldine M., Turner, S., H. P. Wong, G. M. Hartshorne   +7 more
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TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]

, 2012
Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Giraud-Panis, Marie-Josèphe, Marie-Josèphe Giraud-Panis, Giraud-Panis Marie-Josèphe, Giraud-Panis, M.J., Maria Savino (169324), Pinte, Sébastien, Maria Savino, Eric Gilson (139222), Colasanti, Valentina, Bauwens, Serge, Valentina Colasanti (169302), Pusch, Miriam Caroline, Stefano Cacchione, Bauwens Serge, Frédérique Magdinier (169297), Colasanti Valentina, Pinte Sébastien, Magdinier, Frédérique, Miriam Caroline Pusch, Gilson, Eric, Alessandra Galati, Pusch Miriam Caroline, Savino Maria, Ruggero Ricordy (169313), Gilson Eric, Serge Bauwens, M. J. Giraud Panis, Cacchione Stefano, Stefano Cacchione (169328), Magdinier Frédérique, Ruggero Ricordy, Eric Gilson, Frederique Magdinier, Sébastien Pinte (169308), Galati, Alessandra, Cacchione, Stefano, Sebastien Pinte, Marie-Josèphe Giraud-Panis (169317), Galati Alessandra, Savino, Maria, Miriam Caroline Pusch (169321), Valentina Colasanti, Ricordy, Ruggero, Ricordy Ruggero, Alessandra Galati (169293), Serge Bauwens (169304)   +45 more
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Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]

, 2011
Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco, Maria A Blasco, Marión, Rosa M., Ortega Sagrario, Marión Rosa M., Schotta Gunnar, Blasco Maria A., Schotta, Gunnar, Rosa M. Marión, Blasco, Maria A., Gunnar Schotta, Sagrario Ortega, Rosa M Marión, Ortega, Sagrario   +13 more
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Mice with hyper-long telomeres show less metabolic aging and longer lifespans

Nature Communications, 2019
Telomere shortening is associated with aging. Here the authors analyze mice with hyperlong telomeres and demonstrate that longer telomeres than normal have beneficial effects such as delayed metabolic aging, increased longevity and less incidence of ...
Miguel A. Muñoz-Lorente, Alba C. Cano-Martin, Maria A. Blasco   +2 more
doaj   +1 more source

Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases [version 1; referees: 4 approved]

F1000Research, 2016
Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging.
Christian Bär, Maria A. Blasco
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