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Exercise, Telomeres, and Cancer: “The Exercise-Telomere Hypothesis” [PDF]
Frontiers in Physiology, 2018 Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both, shorter TL and cancer are related
Nikitas N. Nomikos +6 more
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Genes, 2022 Telomeres are essential structures formed from satellite DNA repeats at the ends of chromosomes in most eukaryotes. Satellite DNA repeat sequences are useful markers for karyotyping, but have a more enigmatic role in the eukaryotic cell. Much work has been done to investigate the structure and arrangement of repetitive DNA elements in classical models ...
Leon P. Jenner +3 more
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Multiple cancer pathways regulate telomere protection
EMBO Molecular Medicine, 2019 Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cancer. In addition,
Leire Bejarano +9 more
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Haematologica, 2015 Aplastic anemia is a rare but life-threatening disorder characterized by cytopenia in at least two of the three blood lineages. A frequent feature of patients with aplastic anemia is that they have shorter telomeres than those of age-matched controls ...
Christian Bär +3 more
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The Rate of Increase of Short Telomeres Predicts Longevity in Mammals
Cell Reports, 2012 Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telomere maintenance. Normal populations of humans and mice present high interindividual variation in telomere length, but it is unknown whether this is ...
Elsa Vera +4 more
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The EMBO Reports, 2002 Telomeres are protein-DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric
Daniela, Rhodes +4 more
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EMBO Molecular Medicine, 2012 A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity.
Bruno Bernardes de Jesus +6 more
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iScience, 2019 Summary: Telomeres are considered potential anti-cancer targets. Most studies have focused on telomerase inhibition, but this strategy has largely failed in clinical trials.
Leire Bejarano +5 more
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Telomeric recombination induced by dysfunctional telomeres
Molecular Biology of the Cell, 2011 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that ...
Brault, Marie Eve, Autexier, Chantal
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eLife, 2018 Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. We show here that telomerase expression using AAV9
Juan Manuel Povedano +8 more
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