Results 21 to 30 of about 65,288 (296)

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]

, 2012
© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Marija Guc-Scekic, Juan P Trujillo, Maja Zivkovic, Gordana Joksic, Predrag Slijepcevic, Slijepcevic, P, Trujillo, JP, Petrovic, S, Zivkovic, Maja, Joksic, I, Trujillo Quintero, Juan Pablo, Joksic, G, Jordi Surralles, Aleksandra Stankovic, Vujic, D, Zivkovic, M, Vujic, Dragana, Joksic, Gordana, Andreja Leskovac, Joksic, Ivana, Surralles, J, Guc-Scekic, Marija, Maryam Ojani, Ojani, M, Ojani, Maryam, Dragana Vujic, Slijepcevic, Pedrag, Petrovic, Sandra, Sandra Petrovic, Guc-Scekic, M, Stankovic, A, Stankovic, Aleksandra, Leskovac, Andreja, Ivana Joksic, Leskovac, A, Surralles, Jordi   +35 more
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The human telomeric proteome during telomere replication [PDF]

Nucleic Acids Research, 2020
Abstract Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of ...
Chih-Yi Gabriela Lin, Anna Christina Näger, Thomas Lunardi, Aleksandra Vančevska, Gérald Lossaint, Joachim Lingner   +5 more
openaire   +3 more sources

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. [PDF]

, 2011
Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to ...
Tomlinson, IP, A M Jones, Beggs, A. D., Jones, A. M., M Walker, Jones, A.M., Dunlop, MG, Beggs, A.D., Tenesa, A., A D Beggs, Kerr, D, A Zauber, A Tenesa, Hodgson, S. V., Walker, M., M Bertagnolli, R Midgley, Carvajal-Carmona, L, Dunlop, Malcolm, Tenesa, Albert, Tenesa, A, Kerr, D., Jones, AM, Beggs, AD, M G Dunlop, Kerr, David, Jones, A M, Tomlinson, IPM, Carvajal-Carmona, L., Campbell, H.; id_orcid, Tomlinson, I P M, S Ballereau, Tomlinson, I. P. M., Zauber, A., S V Hodgson, Campbell, H, H Campbell, Farrington, S., Hodgson, SV, Ballereau, S., Campbell, H., Midgley, Rachel, Walker, M, S Farrington, I P M Tomlinson, Dunlop, M G, K Howarth, Farrington, S.; id_orcid, Howarth, K., Ballereau, S, Hodgson, S.V., Bertagnolli, M., Tomlinson, I.P., Beggs, A D; id_orcid, Midgley, R., D Kerr, Bertagnolli, M, L Carvajal-Carmona, Hodgson, S V, Dunlop, M. G., Midgley, R, Zauber, A, Howarth, K, Farrington, S   +63 more
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Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells [PDF]

, 2011
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Sapir et al.Background: Recent studies suggest that BRCA2 affects telomere maintenance.
Slijepcevic, P, Yaghoub Gozaly-Chianea, Sainu Ravindran, Ravindran, S, Yasaei, H, Ester Sapir, Predrag Slijepcevic, Suliman Al-Wahiby, Hemad Yasaei, Gozaly-Chianea, Y, Sapir, E, Al-Wahiby, S   +11 more
core   +1 more source

TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]

, 2012
Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Giraud-Panis, Marie-Josèphe, Marie-Josèphe Giraud-Panis, Giraud-Panis Marie-Josèphe, Giraud-Panis, M.J., Maria Savino (169324), Pinte, Sébastien, Maria Savino, Eric Gilson (139222), Colasanti, Valentina, Bauwens, Serge, Valentina Colasanti (169302), Pusch, Miriam Caroline, Stefano Cacchione, Bauwens Serge, Frédérique Magdinier (169297), Colasanti Valentina, Pinte Sébastien, Magdinier, Frédérique, Miriam Caroline Pusch, Gilson, Eric, Alessandra Galati, Pusch Miriam Caroline, Savino Maria, Ruggero Ricordy (169313), Gilson Eric, Serge Bauwens, M. J. Giraud Panis, Cacchione Stefano, Stefano Cacchione (169328), Magdinier Frédérique, Ruggero Ricordy, Eric Gilson, Frederique Magdinier, Sébastien Pinte (169308), Galati, Alessandra, Cacchione, Stefano, Sebastien Pinte, Marie-Josèphe Giraud-Panis (169317), Galati Alessandra, Savino, Maria, Miriam Caroline Pusch (169321), Valentina Colasanti, Ricordy, Ruggero, Ricordy Ruggero, Alessandra Galati (169293), Serge Bauwens (169304)   +45 more
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Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]

, 2010
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
J. Rai, Rai, J., S. Turner, Wong, H. P., Hartshorne, Geraldine M., Turner, S., H. P. Wong, G. M. Hartshorne   +7 more
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Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]

, 2011
Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco, Maria A Blasco, Marión, Rosa M., Ortega Sagrario, Marión Rosa M., Schotta Gunnar, Blasco Maria A., Schotta, Gunnar, Rosa M. Marión, Blasco, Maria A., Gunnar Schotta, Sagrario Ortega, Rosa M Marión, Ortega, Sagrario   +13 more
core   +1 more source

Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases [version 1; referees: 4 approved]

F1000Research, 2016
Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging.
Christian Bär, Maria A. Blasco
doaj   +1 more source

The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. [PDF]

PLoS Genetics, 2015
Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB).
Jane A Phillips, Angela Chan, Katrin Paeschke, Virginia A Zakian   +3 more
doaj   +1 more source

XPF activates break-induced telomere synthesis

Nature Communications, 2022
Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend ...
Chia-Yu Guh, Hong-Jhih Shen, Liv WeiChien Chen, Pei-Chen Chiu, I-Hsin Liao, Chen-Chia Lo, Yunfei Chen, Yu-Hung Hsieh, Ting-Chia Chang, Chien-Ping Yen, Yi-Yun Chen, Tom Wei-Wu Chen, Liuh-Yow Chen, Ching-Shyi Wu, Jean-Marc Egly, Hsueh-Ping Catherine Chu   +15 more
doaj   +1 more source