Results 41 to 50 of about 47,118 (266)
Aging CellABSTRACTRecent studies have reported that the spaceflight environment lengthens leukocyte telomeres. We propose that this baffling finding reflects changes in the composition of leukocyte subsets rather than an actual increase in telomere length within individual leukocytes.
Abraham Aviv, Simon Verhulst
openaire +2 more sources
Senescence, Telomere Shortening and Telomere Maintenance [PDF]
Cancer Biology & Therapy, 2002 No Abstract Available Commentary to: Title: Telomerase Protects Cancer-Prone Human Cells from Chromosomal Instability and Spontaneous Immortalization Authors: Lynne W. Elmore, Kristi C. Turner, Lauren S. Gollahon, Melissa R. Landon, Colleen K. Jackson-Cook and Shawn E.
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity. [PDF]
PLoS ONE, 2016 Telomeres are capped at the ends of eukaryotic chromosomes and are composed of TTAGGG repeats bound to the shelterin complex. Here we report that a replication-dependent histone H2A isotype, H2ac, was associated with telomeres in human cells and co ...
Chia-Hsin Su +4 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The Role of Telomeres and Telomerase in Human Aging and Aging Associated Diseases
مجلة جامعة الزيتونة, 2022 An expanding confirmation for the existence of an imperative association between telomeres and cellular aging. With each cell division ordinary human cells dynamically lose telomeres until many telomeres become uncapped driving the cells to risk ...
Haowa Madi
doaj +2 more sources
Long telomeres: too much of a good thing
Biomolecular Concepts, 2012 Telomeres, the physical ends of linear eukaryotic chromosomes, protect chromosome ends from end fusions and degradation. Telomere length is tightly regulated to ensure that telomeres are neither too short nor too long.
Chang Michael
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Long Telomeres Do Not Affect Cellular Fitness in Yeast
mBio, 2017 Telomeres, the ends of the eukaryotic chromosomes, help to maintain the genome’s integrity and thus play important roles in aging and cancer. Telomere length is strictly controlled in all organisms.
Yaniv Harari +2 more
doaj +1 more source
Telomeres and telomerase [PDF]
Genes & Development, 1999 Telomeres are in the spotlight of modern biology. Whether the subject at hand is cancer, gene regulation, organismal aging, or the cloning of mammals, much seems to depend on what happens at the ends of chromosomes. Because glamorous hypotheses often persist without experimental support, it is important to ask ourselves what we really know about ...
Blasco, M. A. +2 more
openaire +2 more sources