Results 61 to 70 of about 66,266 (300)
The Role of Telomeres and Telomerase in Human Aging and Aging Associated Diseases
مجلة جامعة الزيتونة, 2022 An expanding confirmation for the existence of an imperative association between telomeres and cellular aging. With each cell division ordinary human cells dynamically lose telomeres until many telomeres become uncapped driving the cells to risk ...
Haowa Madi
doaj +2 more sources
Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks
, 2018 Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear chromosomes, or those at DNA double-strand breaks (DSBs). In eukaryotes, DNA ends at chromosomal termini are packaged into proteinaceous structures called
Ulrich Rass (5755565) +12 more
core +1 more source
Epiphenomenon of telomere lengths : lessons from ulcerative colitis [PDF]
, 2012 We read with great interest the article by Jones et al detailing TERC polymorphisms, longer telomeres and increased risk of colorectal cancer (CRC).1 Indeed, it is accepted that shorter telomere lengths (measured from peripheral leucocytes) have been ...
Arasaradnam, Ramesh P. +1 more
core +1 more source
Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali +4 more
wiley +1 more source
At short telomeres Tel1 directs early replication and phosphorylates Rif1.
PLoS Genetics, 2014 The replication time of Saccharomyces cerevisiae telomeres responds to TG1-3 repeat length, with telomeres of normal length replicating late during S phase and short telomeres replicating early.
Akila Sridhar +2 more
doaj +1 more source
Cell Discovery, 2023 Telomeres, at the ends of chromosomes, protect chromosomes from fusion and preserve genomic stability. However, the molecular mechanisms underlying telomere attrition-induced genome instability remain to be understood.
Nannan Zhao +14 more
doaj +1 more source
The EMBO Reports, 2002 Telomeres are protein-DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric
Daniela, Rhodes +4 more
openaire +2 more sources
Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini +9 more
wiley +1 more source
Investigation of telomere maintenance in BRCA2 defective mammalian cell lines [PDF]
, 2014 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityBRCA2 is a highly penetrant breast cancer predisposing gene.
Gozaly Chianea, Yaghoub
core +3 more sources
An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity. [PDF]
PLoS ONE, 2016 Telomeres are capped at the ends of eukaryotic chromosomes and are composed of TTAGGG repeats bound to the shelterin complex. Here we report that a replication-dependent histone H2A isotype, H2ac, was associated with telomeres in human cells and co ...
Chia-Hsin Su +4 more
doaj +1 more source