Results 51 to 60 of about 59,567 (314)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Alternative lengthening of telomeres (ALT) is characterized by reduced compaction of telomeric chromatin.

, 2014
Proper telomeric chromatin configuration is thought to be essential for telomere homeostasis and stability. Previous studies in mouse suggested that loss of heterochromatin marks at telomeres might favor onset of Alternative Lengthening of Telomeres (ALT)
Gobin, Matthieu, Episkopou, Harikleia, Decottignies, Anabelle, Draskovic, Irena, Mattiussi, Marina, Episkopou, Charikleia, Londono-Vallejo, Arturo, Van Beneden, Amandine, Tilman, Gaëlle, Arnoult, Nausica, Telomeres, Telomerase and Disease   +10 more
core   +1 more source

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

Nature Communications, 2018
Long non-coding RNA TERRAs are essential for telomere protection and telomere length maintenance. Here the authors report a role for TERRAs in telomeric heterochromatin formation by recruiting Polycomb Repressive Complex 2 to telomeres.
Juan J. Montero, Isabel López-Silanes, Diego Megías, Mario F. Fraga, Álvaro Castells-García, Maria A. Blasco   +5 more
doaj   +1 more source

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

Cell Reports, 2015
Idiopathic pulmonary fibrosis (IPF) is a degenerative disease of the lungs with an average survival post-diagnosis of 2–3 years. New therapeutic targets and treatments are necessary.
Juan M. Povedano, Paula Martinez, Juana M. Flores, Francisca Mulero, Maria A. Blasco   +4 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Telomeres in Space

Aging Cell
ABSTRACTRecent studies have reported that the spaceflight environment lengthens leukocyte telomeres. We propose that this baffling finding reflects changes in the composition of leukocyte subsets rather than an actual increase in telomere length within individual leukocytes.
Abraham Aviv, Simon Verhulst
openaire   +2 more sources

Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae" [PDF]

, 2007
Protein phosphorylation mediated by checkpoint kinases is crucial for the cellular response to DNA damage. The sensor kinases Mec1 and Tel1 initiate the checkpoint signaling cascade by directly activating the checkpoint effector kinase Rad53.
Schleker, Thomas Andreas
core   +1 more source

Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cells

Cell Discovery, 2023
Telomeres, at the ends of chromosomes, protect chromosomes from fusion and preserve genomic stability. However, the molecular mechanisms underlying telomere attrition-induced genome instability remain to be understood.
Nannan Zhao, Guoxing Yin, Chun Liu, Weiyu Zhang, Yang Shen, Dan Wang, Zhenzhen Lin, Jiao Yang, Jian Mao, Renpeng Guo, Yongwang Zhang, Feng Wang, Zhe Liu, Xinyi Lu, Lin Liu   +14 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Telomeres and telomerase [PDF]

Genes & Development, 1999
Telomeres are in the spotlight of modern biology. Whether the subject at hand is cancer, gene regulation, organismal aging, or the cloning of mammals, much seems to depend on what happens at the ends of chromosomes. Because glamorous hypotheses often persist without experimental support, it is important to ask ourselves what we really know about ...
M A, Blasco, S M, Gasser, J, Lingner
openaire   +2 more sources