Results 51 to 60 of about 65,288 (296)
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Nature Communications, 2018 Long non-coding RNA TERRAs are essential for telomere protection and telomere length maintenance. Here the authors report a role for TERRAs in telomeric heterochromatin formation by recruiting Polycomb Repressive Complex 2 to telomeres.
Juan J. Montero +5 more
doaj +1 more source
Cell Discovery, 2023 Telomeres, at the ends of chromosomes, protect chromosomes from fusion and preserve genomic stability. However, the molecular mechanisms underlying telomere attrition-induced genome instability remain to be understood.
Nannan Zhao +14 more
doaj +1 more source
Senescence, Telomere Shortening and Telomere Maintenance [PDF]
Cancer Biology & Therapy, 2002 No Abstract Available Commentary to: Title: Telomerase Protects Cancer-Prone Human Cells from Chromosomal Instability and Spontaneous Immortalization Authors: Lynne W. Elmore, Kristi C. Turner, Lauren S. Gollahon, Melissa R. Landon, Colleen K. Jackson-Cook and Shawn E.
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Role of Telomeres and Telomerase in Human Aging and Aging Associated Diseases
مجلة جامعة الزيتونة, 2022 An expanding confirmation for the existence of an imperative association between telomeres and cellular aging. With each cell division ordinary human cells dynamically lose telomeres until many telomeres become uncapped driving the cells to risk ...
Haowa Madi
doaj +2 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Long telomeres: too much of a good thing
Biomolecular Concepts, 2012 Telomeres, the physical ends of linear eukaryotic chromosomes, protect chromosome ends from end fusions and degradation. Telomere length is tightly regulated to ensure that telomeres are neither too short nor too long.
Chang Michael
doaj +1 more source
An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity. [PDF]
PLoS ONE, 2016 Telomeres are capped at the ends of eukaryotic chromosomes and are composed of TTAGGG repeats bound to the shelterin complex. Here we report that a replication-dependent histone H2A isotype, H2ac, was associated with telomeres in human cells and co ...
Chia-Hsin Su +4 more
doaj +1 more source
Aging CellABSTRACTRecent studies have reported that the spaceflight environment lengthens leukocyte telomeres. We propose that this baffling finding reflects changes in the composition of leukocyte subsets rather than an actual increase in telomere length within individual leukocytes.
Abraham Aviv, Simon Verhulst
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