Results 71 to 80 of about 66,266 (300)

Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene [PDF]

, 2003
Leishmania parasites (order Kinetoplastida, family Trypanosomatidae) cause a spectrum of human diseases ranging from asymptomatic to lethal. The approximately 33.6 Mb genome is distributed among 36 chromosome pairs that range in size from approximately 0.
Fu, Guoliang, Schnaufer, Achim; id_orcid, Sisk, Ellen, Martinez-Calvillo, Santiago, Ivens, Alasdair C, Hixson, Greg, Aggarwal, Gautam, Fazelinia, Gholam, Fong, Chris, Sunkin, Susan M, Worthey, E A, Salavati, Reza, Hassebrock, Melissa, Marsolini, Felicia, Rickell, Erica, Kiser, Patti, Stuart, Kenneth D, Cawthra, Jason, Rickel, Erika, Myler, Peter J   +19 more
core   +1 more source

Effect Modification of Cigarette Smoking on the Relationship Between Posttraumatic Stress Disorder, Other Mental Health Conditions, and Rheumatoid Arthritis Risk: A Large Case‐Control Study in US Veterans

Arthritis Care &Research, EarlyView.
Objective We examined associations of posttraumatic stress disorder (PTSD) and other mental health disorders (OMH) with rheumatoid arthritis (RA), accounting for effects of smoking. Methods We conducted a matched case‐control study, identifying incident RA cases and controls using national Veterans Health Administration data (2006–2019).
Kelsey Coziahr, Harlan Sayles, Tate M. Johnson, Joshua F. Baker, Punyasha Roul, Grant W. Cannon, Gary A. Kunkel, Katherine D. Wysham, Gail S. Kerr, Amir A. Razmjou, Isaac Smith, Jennifer L. Barton, Maria I. Danila, Jonathan S. Richards, Bryant R. England, Ted R. Mikuls   +15 more
wiley   +1 more source

Long Telomeres Do Not Affect Cellular Fitness in Yeast

mBio, 2017
Telomeres, the ends of the eukaryotic chromosomes, help to maintain the genome’s integrity and thus play important roles in aging and cancer. Telomere length is strictly controlled in all organisms.
Yaniv Harari, Shira Zadok-Laviel, Martin Kupiec   +2 more
doaj   +1 more source

The Mph1 helicase can promote telomere uncapping and premature senescence in budding yeast. [PDF]

PLoS ONE, 2012
Double strand breaks (DSBs) can be repaired via either Non-Homologous End Joining (NHEJ) or Homology directed Repair (HR). Telomeres, which resemble DSBs, are refractory to repair events in order to prevent chromosome end fusions and genomic instability.
Sarah Luke-Glaser, Brian Luke
doaj   +1 more source

Telomere Length and Physical Performance at Older Ages: An Individual Participant Meta-Analysis [PDF]

, 2013
Background Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence ...
Hardy, R, John M. Starr (107707), Cooper, R, Rachel Cooper, von Zglinicki, Thomas, Halcyon study team, Parsons, Sam, Martin-Ruiz, C., Lennox, Alison, Kuh, D., Murray, Emily, Yoav Ben-Shlomo, Aihie Sayer, Avan, Shiels, Paul G, Thomas von Zglinicki, Martin, Richard, Carmen Martin-Ruiz (126509), Cooper Cyrus, Hardy, R., Hardy, Rachel, Deary, Ian, Gardner, M.P., Team, HS, Cooper, Cryus, von Zglinicki, T., Sayer Avan Aihie, John M Starr, Shiels, P.G., Ben-Shlomo, Yoav, Ian J. Deary (107724), Harris, Sarah E, Gardner, Michael, Sayer, AA, Day, Ian, team, Halcyon study, Sarah E Harris, Ian J Deary, Gallacher, J., Aucott, Paula, Harris, Sarah, Martin-Ruiz, C, Paul G Shiels, Gardner, MP, Southall, Humphrey, Kuh, Diana, Rebecca Hardy (188906), von Zglinicki Thomas, Deary, Ian J, Michael P. Gardner (381155), Goodwin, James, Michael P Gardner, Thomas von Zglinicki (73277), Yoav Ben-Shlomo (95286), Alfred, Tamuno, Cooper, C., Diana Kuh, Gallacher John, Ben-Shlomo, Y., Starr John M., Deary Ian J., Elliott, Jane, Cooper, C, Starr, J.M., Shiels, Paul G., Shiels, Paul, Rachel Cooper (188902), Shiels, PG, Harris Sarah E., Kuh Diana, Gallacher, John, Gardner, Michael P., Craig, Leone, Richards, Marcus, Starr, John M., John Gallacher, Mulla, Zeinab, Starr, John M, Gale, Catherine, Ben-Shlomo, Y, Carmen Martin-Ruiz, Demakakos, Panos, Gardner, Mike P, Cyrus Cooper (141250), Cooper, R., John Gallacher (196569), Sayer, A.A., Cyrus Cooper, Harris, S.E., Hardy, Rebecca, McNeill, Geraldine, Starr, JM, Harris, SE, ?, ?, Avan Aihie Sayer, Cooper, Rachel, Deary, IJ, Cooper Rachel, Gardner, Michael P, Avan Aihie Sayer (188916), Rebecca Hardy, Whalley, Lawrence, Shiels Paul G., Martin-Ruiz Carmen, Hardy Rebecca, Martin-Ruiz, Carmen, Deary, Ian J., Tilling, Kate, Harris, Sarah E., Gardner Michael P., Cooper, Cyrus, Power, Chris, Paul G. Shiels (125083), Sayer, Avan Aihie, Gallacher, J, Mishra, Gita, von Zglinicki, T, Kuh, D, von, Zglinicki T, Steptoe, Andrew, Ben-Shlomo Yoav, Sarah E. Harris (107676), Diana Kuh (188923), Starr, John, Deary, I.J.   +123 more
core   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae" [PDF]

, 2007
Protein phosphorylation mediated by checkpoint kinases is crucial for the cellular response to DNA damage. The sensor kinases Mec1 and Tel1 initiate the checkpoint signaling cascade by directly activating the checkpoint effector kinase Rad53.
Schleker, Thomas Andreas
core   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +2 more sources

Telomerase Repairs Collapsed Replication Forks at Telomeres

Cell Reports, 2020
Summary: Telomeres are difficult-to-replicate sites whereby replication itself may threaten telomere integrity. We investigate, in fission yeast, telomere replication dynamics in telomerase-negative cells to unmask problems associated with telomere ...
Samah Matmati, Sarah Lambert, Vincent Géli, Stéphane Coulon   +3 more
doaj   +1 more source