Results 81 to 90 of about 66,266 (300)
Exercise, Telomeres, and Cancer: “The Exercise-Telomere Hypothesis” [PDF]
Frontiers in Physiology, 2018 Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both, shorter TL and cancer are related
Nikitas N. Nomikos +6 more
openaire +5 more sources
Advanced Science, EarlyView.Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu +7 more
wiley +1 more source
TERRA, hnRNP A1 and DNA-PKcs interactions at human telomeres
Frontiers in Oncology, 2013 Maintenance of telomeres, repetitive elements at eukaryotic chromosomal termini, and the end-capping structure and function they provide, are imperative for preserving genome integrity and stability.
Phuong N. Le +4 more
doaj +1 more source
Telomere Length and Distribution in Three Developmental Stages [PDF]
, 2014 Telomeres are specialised nucleoprotein structures present at the ends of each chromatid that function to maintain genome stability. It is well established that a gradual decline in telomere length is associated with the process of cellular ageing, and ...
Digital Scientific, Turner, Kara Jane
core
Advanced Science, EarlyView.Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao +25 more
wiley +1 more source
Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly
Cell Reports, 2012 Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse confocal microscopy allowed us to evaluate the spatial distribution of telomeres within the ...
Laure Crabbe +4 more
doaj +1 more source
Genome assembly in the telomere-to-telomere era
Nature Reviews GeneticsDe novo assembly is the process of reconstructing the genome sequence of an organism from sequencing reads. Genome sequences are essential to biology, and assembly has been a central problem in bioinformatics for four decades. Until recently, genomes were typically assembled into fragments of a few megabases at best but technological advances in long ...
Heng Li, Richard Durbin
openaire +4 more sources
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells
Nature Communications, 2021 Telomeres can be maintained by a telomerase-independent mechanism called an alternative lengthening of telomeres (ALT). Here the authors use mouse Terc (telomerase RNA) knockout embryonic cells and provide longitudinal analysis of ALT telomeres ...
Chuna Kim +13 more
doaj +1 more source
, 2022 International audienceAlthough the impact of telomeres on physiology stands well established, a question remains: how do telomeres impact cellular functions at a molecular level?
Vinayagamurthy, Soujanya +3 more
core +1 more source