Results 81 to 90 of about 59,567 (314)
Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene [PDF]
, 2003 Leishmania parasites (order Kinetoplastida, family Trypanosomatidae) cause a spectrum of human diseases ranging from asymptomatic to lethal. The approximately 33.6 Mb genome is distributed among 36 chromosome pairs that range in size from approximately 0.
Fu, Guoliang +19 more
core +1 more source
TERRA, hnRNP A1 and DNA-PKcs interactions at human telomeres
Frontiers in Oncology, 2013 Maintenance of telomeres, repetitive elements at eukaryotic chromosomal termini, and the end-capping structure and function they provide, are imperative for preserving genome integrity and stability.
Phuong N. Le +4 more
doaj +1 more source
Advanced Science, EarlyView.SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu +11 more
wiley +1 more source
F1000 Medicine Reports, 2012 Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects in them result in various diseases. This review examines recent advances in understanding these diseases, particularly at a molecular level, and in relating telomere dysfunction to clinical diseases.
Calado, Rodrigo, Young, Neal
openaire +2 more sources
Telomere Length and Distribution in Three Developmental Stages [PDF]
, 2014 Telomeres are specialised nucleoprotein structures present at the ends of each chromatid that function to maintain genome stability. It is well established that a gradual decline in telomere length is associated with the process of cellular ageing, and ...
Digital Scientific, Turner, Kara Jane
core
Mechanozyme: An Artificial Enzyme With a Mechanophore Framework
Advanced Science, EarlyView.Mechanical destabilization of a G‐quadruplex mechanophore in a DNAzyme markedly boosts its catalytic activity, demonstrating “mechanozymes” as artificial enzymes whose functions are modulated by mechanical stress exerted by ultrasonication. This mechanozyme principle is broadly applicable to control biomolecular activities.
Jiahao Ji +7 more
wiley +1 more source
The Ruminant Telomere-to-Telomere (RT2T) Consortium
Nature GeneticsTelomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies ...
Kalbfleisch, Theodore +77 more
openaire +3 more sources
Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly
Cell Reports, 2012 Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse confocal microscopy allowed us to evaluate the spatial distribution of telomeres within the ...
Laure Crabbe +4 more
doaj +1 more source
Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells
Nature Communications, 2021 Telomeres can be maintained by a telomerase-independent mechanism called an alternative lengthening of telomeres (ALT). Here the authors use mouse Terc (telomerase RNA) knockout embryonic cells and provide longitudinal analysis of ALT telomeres ...
Chuna Kim +13 more
doaj +1 more source