Results 101 to 110 of about 47,118 (266)
Sex Differences in Telomere Length in a Bat With Female‐Biased Longevity
Ecology and EvolutionTelomeres, protective caps at the ends of linear chromosomes, are frequently found to shorten with age. Telomere length is commonly measured in wild populations to investigate age‐related changes in somatic integrity and is considered a hallmark of ...
Jack G. Rayner +5 more
doaj +1 more source
AI Powered Biobanks From Static Archives to Dynamic Discovery Engines
Advanced Intelligent Discovery, EarlyView.Large language models (LLMs) provide a potential framework for transforming biobanks from static data repositories into intelligent discovery engines. By enabling unified representation and analysis of multimodal biomedical data, LLM‐based systems facilitate dynamic risk prediction, biomarker identification, and mechanistic interpretation, thereby ...
Wenzhen Yin +5 more
wiley +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent late‐onset neurodegenerative diseases worldwide. Both are influenced in part by genetic factors and are currently incurable. Tobacco and alcohol, the two most common substances used among the general adult population, are potential AD/PD risk factors and are also ...
Linda Wang +3 more
wiley +1 more source
Telomeres and atherosclerosis.
Cardiovascular journal of Africa, 2012 In humans and other multicellular organisms that have an extended lifespan, the leading causes of death are atherosclerotic cardiovascular disease and cancer. Experimental and clinical evidence indicates that these age-related disorders are linked through dysregulation of telomere homeostasis.
Khan, Sajidah +2 more
openaire +2 more sources
A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants
Applications in Plant Sciences, EarlyView.Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk +6 more
wiley +1 more source
Journal of Cell Science, 2012 The linearity of chromosomes creates two major problems for eukaryotic cells: the end-replication problem and the end-protection problem. The end-replication problem stems from the inherent inability of the replication machinery to fully duplicate linear templates.
openaire +3 more sources
BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
ALTered telomeres in response to telomere dysfunction [PDF]
Cell Cycle, 2011 Marie Eve, Brault, Chantal, Autexier
openaire +2 more sources
Oocyte–cumulus cell interaction: a key factor in early embryo development
Biological Reviews, EarlyView.ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido +2 more
wiley +1 more source