Results 101 to 110 of about 114,134 (356)

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source

AI Powered Biobanks From Static Archives to Dynamic Discovery Engines

Advanced Intelligent Discovery, EarlyView.
Large language models (LLMs) provide a potential framework for transforming biobanks from static data repositories into intelligent discovery engines. By enabling unified representation and analysis of multimodal biomedical data, LLM‐based systems facilitate dynamic risk prediction, biomarker identification, and mechanistic interpretation, thereby ...
Wenzhen Yin, Yutian Feng, Wenrui Ma, Yuxin Su, Li Min, Juan Liu   +5 more
wiley   +1 more source

Aging and Immortality in a Cell Proliferation Model

, 2008
We investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres ...
Abramowitz, Bailey, Bailey, Bryan, Campisi, Campisi, Campisi, Carey, Fleming, Gikhman, Gradshteyn, Harley, Hasenmaile, Hayflick, Henson, K.B. Blagoev, Karlin, Nisbet, Olovnikov, Reddel, Redner, S. Redner, S.A. Trugman, Steinsaltz, T. Antal, Watson, Weitz   +26 more
core   +1 more source

Dna2 Helicase/Nuclease Causes Replicative Fork Stalling and Double-strand Breaks in the Ribosomal DNA of Saccharomyces cerevisiae [PDF]

, 2003
We have proposed that faulty processing of arrested replication forks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae and contributes to the shortened lifespan of dna2 mutants. Now we use the ribosomal DNA locus,
Budd, Martin, Campbell, Judith L., Mays Hoopes, Laura L., Weitao, Tao   +3 more
core   +2 more sources

Biodegradable and Bioinspired UV Light Recognition via Sustainable Synaptic Transistors for Artificial Intelligence Vision Systems

Advanced Intelligent Systems, EarlyView.
We report a biodegradable electrolyte‐gated synaptic phototransistor that combines low‐power UV sensing with memory functionality, offering a sustainable platform for AI vision systems and health‐monitoring technologies. Presented here is a biodegradable, bioinspired synaptic phototransistor (SPT) based on an electrolyte‐gated field‐effect transistor ...
Theodoros Serghiou, Rogério Morais, Douglas Henrique Vieira, Neri Alves, Roghaieh Parvizi, Jeff Kettle   +5 more
wiley   +1 more source

mTert induction in p21-positive cells counteracts capillary rarefaction and pulmonary emphysema

EMBO Reports
Lung diseases develop when telomeres shorten beyond a critical point. We constructed a mouse model in which the catalytic subunit of telomerase (mTert), or its catalytically inactive form (mTertCI), is expressed from the p21Cdkn1a locus.
Larissa Lipskaia, Marielle Breau, Christelle Cayrou, Dmitri Churikov, Laura Braud, Juliette Jacquet, Emmanuelle Born, Charles Fouillade, Sandra Curras-Alonso, Serge Bauwens, Frederic Jourquin, Frederic Fiore, Rémy Castellano, Emmanuelle Josselin, Carlota Sánchez-Ferrer, Giovanna Giovinazzo, Christophe Lachaud, Eric Gilson, Ignacio Flores, Arturo Londono-Vallejo, Serge Adnot, Vincent Géli   +21 more
doaj   +1 more source

Therapeutic inhibition of TRF1 impairs the growth of p53‐deficient K‐RasG12V‐induced lung cancer by induction of telomeric DNA damage

EMBO Molecular Medicine, 2015
Telomeres are considered anti‐cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer‐prone mouse models, however, only decreased tumor growth after several mouse generations when ...
María García‐Beccaria, Paula Martínez, Marinela Méndez‐Pertuz, Sonia Martínez, Carmen Blanco‐Aparicio, Marta Cañamero, Francisca Mulero, Chiara Ambrogio, Juana M Flores, Diego Megias, Mariano Barbacid, Joaquín Pastor, Maria A Blasco   +12 more
doaj   +1 more source

Pathogenic PF4/Polyanion ELISA‐Negative Antibodies in HIT

American Journal of Hematology, EarlyView.
ABSTRACT Background Platelet factor 4‐polyanion enzyme‐linked immunosorbent assays (ELISAs) are considered highly sensitive for diagnosing heparin‐induced thrombocytopenia (HIT), such that current practice guidelines recommend use of ELISA‐negative results to exclude HIT.
Adam J. Kanack, Noah P. Splinter, Emily E. Mauch, Leben Tefera, Morayma Reyes Gil, Sakshi Jasra, Andrew Goodwin, Kristi J. Smock, Hadiyah Ahmad, Aneel Ashrani, Nathaniel L. Robinson, Ana I. Casanegra, Curtis G. Jones, Shannon M. Pechauer, Erin Yttre, Richard H. Aster, Mindy C. Kohlhagen, Rachel R. Leger, Gretchen Johns, David L. Murray, Lu Zhou, Demin Wang, Renren Wen, Dong Chen, Rajiv K. Pruthi, Anand Padmanabhan   +25 more
wiley   +1 more source

Repeated stressors in adulthood increase the rate of biological ageing [PDF]

, 2015
Background Individuals of the same age can differ substantially in the degree to which they have accumulated tissue damage, akin to bodily wear and tear, from past experiences.
Adelman, James S., Costantini, David, Greives, Timothy J., Hau, Michaela, Haussmann, Mark F., Matlack, Christa, Miranda, Ana Catarina, Partecke, Jesko, Quetting, Michael   +8 more
core   +2 more sources

De Novo Complex Genomic Rearrangement Spanning 2q31.1 in a Proband With Congenital Malformations: Genotype–Phenotype Correlation and Development of a CGR Detection Pipeline

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The 2q31 region is commonly associated with pathogenic alleles of the HOXD cluster leading to various clinical phenotypes related to skeletal development. We present a proband with tetralogy of Fallot and multiple congenital anomalies. Genomic variant screening including an in‐house CGR detection pipeline pairing genome sequencing (GS ...
Katherine Helle, Jesse D. Bengtsson, Mira Gandhi, Christopher M. Grochowski, Ming Yin Lun, Neha Sudhir, Shalini N. Jhangiani, Fritz J. Sedlazeck, Seema R. Lalani, Neil A. Hanchard, Claudia M. B. Carvalho   +10 more
wiley   +1 more source