Results 101 to 110 of about 66,266 (300)
Advanced Intelligent Systems, EarlyView.Cancer cells progressively spread over intermediate epithelial‐to‐mesenchymal transition states that cause nuclear enlargement and circular redistribution of filamentous vimentin are classified by deformability cytometry coupled to a multi‐region deep learning model with convolutional feature extraction and attention‐based regional aggregation.
Javad Jarmoshti +8 more
wiley +1 more source
EMBO Molecular Medicine, 2015 Telomeres are considered anti‐cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer‐prone mouse models, however, only decreased tumor growth after several mouse generations when ...
María García‐Beccaria +12 more
doaj +1 more source
Telomeres and telomerase in the clinical management of colorectal cancer
, 2017 Colorectal cancer (CRC) is the third most common cancer worldwide. Our aim is to describe the state of the art about the role of telomeres and telomerase in the clinical management of CRC and its potential utility as prognostic and diagnostic biomarkers ...
Viñas-Salas, J. +3 more
core +1 more source
Advanced NanoBiomed Research, EarlyView.Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang +12 more
wiley +1 more source
Cell Reports, 2014 The conserved protein Rap1 functions at telomeres in fungi, protozoa, and vertebrates. Like yeast Rap1, human Rap1 has been implicated in telomere length regulation and repression of nonhomologous end-joining (NHEJ) at telomeres. However, mouse telomeres
Shaheen Kabir +2 more
doaj +1 more source
Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin.
, 2014 Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric ...
Episkopou, Charikleia +1 more
core
The EMBO Journal, 2009 The telomeres of most eukaryotes are characterized by guanine-rich repeats synthesized by the reverse transcriptase telomerase. Complete loss of telomerase is tolerated for several generations in most species, but modestly reduced telomerase levels in human beings are implicated in bone marrow failure, pulmonary fibrosis and a spectrum of other ...
openaire +2 more sources
Modulation of telomere protection by the PI3K/AKT pathway
Nature Communications, 2017 Regulation of telomeres and the insulin/PI3K pathway both have roles in aging and cancer development but have not been functionally linked. Here the authors demonstrate that PI3K, via downstream targets, regulates TRF1 via phosphorylation.
Marinela Méndez-Pertuz +10 more
doaj +1 more source
Telomeres: the silence is broken
, 2008 The ends of linear eukaryotic chromosomes, telomeres, distinguish natural chromosome ends from DNA double stranded breaks and thus promote genome stability.
Azzalin, C. M. +5 more
core +1 more source
Mammalian telomeres and their partnership with lamins [PDF]
, 2016 Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA +5 more
core +1 more source