Chromatin features of plant telomeric sequences at terminal versus internal positions
Frontiers in Plant Science, 2014 Epigenetic mechanisms are involved in regulation of crucial cellular processes in eukaryotic organisms. Data on the epigenetic features of plant telomeres and their epigenetic regulation were published mostly for Arabidopsis thaliana, in which the ...
Eva eMajerová +7 more
doaj +1 more source
Early-life adversity accelerates cellular ageing and affects adult inflammation: experimental evidence from the European starling [PDF]
, 2017 Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter ...
Andrews, Clare +8 more
core +4 more sources
A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants
Applications in Plant Sciences, EarlyView.Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk +6 more
wiley +1 more source
Acacetin and Chrysin, Two Polyphenolic Compounds, Alleviate Telomeric Position Effect in Human Cells
Molecular Therapy: Nucleic Acids, 2013 We took advantage of the ability of human telomeres to silence neighboring genes (telomere position effect or TPE) to design a high-throughput screening assay for drugs altering telomeres.
Amina Boussouar +11 more
doaj +1 more source
Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]
, 1990 The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Barry, J D +3 more
core +1 more source
Animal Research and One Health, EarlyView.Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri +8 more
wiley +1 more source
Highly Aggressive Metastatic Melanoma Cells Unable to Maintain Telomere Length
Cell Reports, 2017 Summary: Unlimited replicative potential is one of the hallmarks of cancer cells. In melanoma, hTERT (telomerase reverse transcriptase) is frequently overexpressed because of activating mutations in its promoter, suggesting that telomerase is necessary ...
Nikenza Viceconte +6 more
doaj +1 more source
Is socioeconomic status associated with biological aging as measured by telomere length? [PDF]
, 2012 It has been hypothesized that one way in which lower socioeconomic status (SES) affects health is by increasing the rate of biological aging. A widely used marker of biological aging is telomere length. Telomeres are structures at the ends of chromosomes
Adams +46 more
core +3 more sources
RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity [PDF]
, 2012 Jean‐Baptiste Vannier +4 more
openalex +1 more source