Results 131 to 140 of about 66,266 (300)

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source

Garter snake telomeres and condition

, 2017
Garter snake telomeres and ...
Nicky Rollings (3818977), Waye, Heather, Friesen, Christopher, Randolf Krohmer (3818986), Krohmer, Randolf, Robert Mason (3269031), Christopher Friesen (3321645), Uhrig, Emily, Mats Olsson (351776), Mason, Robert, Whittington, Camilla, Rollings, Nicky, Olsson, Mats, Emily Uhrig (3321648), Heather Waye (3818980), Camilla Whittington (3818983)   +15 more
core   +1 more source

Cytotoxic and Genotoxic Effects in Buccal Cells of Sandstone Quarry Workers

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mineral extraction poses significant occupational health risks, particularly from respirable crystalline silica exposure. Sandstone quarrying generates substantial dust, yet evidence of its genotoxic effects remains limited. This study investigated cytogenotoxic damage in sandstone quarry workers from southern Brazil using the buccal ...
Ana Carolina de Quadros Duarte, Maria Isabela Toniazzo, Rayne Vallada da Luz, Cleisson Guimarães Bueno, Daniela Müller de Quevedo, Luciano Basso da Silva, Daiane Bolzan Berlese   +6 more
wiley   +1 more source

Telomeres [PDF]

Current Biology, 2001
openaire   +2 more sources

Sex‐Specific Early Life Corticosterone Stress‐Coping Capacity Is Linked to Mitochondrial Content and Telomere Maintenance

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Glucocorticoids are upregulated during acute challenges, contributing to maintenance of energy balance. However, if this upregulation exceeds a threshold or becomes chronic, it can lead to harmful effects. Investigating the factors behind between‐individual variation in the magnitude of the response to acute stress and how effectively ...
Mauricio Guillen‐Parra, Alberto Velando, Bibiana Montoya, Roxana Torres   +3 more
wiley   +1 more source

Sex Differences in Telomere Length in a Bat With Female‐Biased Longevity

Ecology and Evolution
Telomeres, protective caps at the ends of linear chromosomes, are frequently found to shorten with age. Telomere length is commonly measured in wild populations to investigate age‐related changes in somatic integrity and is considered a hallmark of ...
Jack G. Rayner, Abigail Marshall, Danielle M. Adams, Jillian Kaiser, Katherine Armenta, Gerald S. Wilkinson   +5 more
doaj   +1 more source

Vedolizumab use for severe chronic enterocolitis in a child with Hoyeraal–Hreidarsson syndrome: A case report

JPGN Reports, EarlyView.
Abstract We report a patient with Hoyeraal–Hreidarsson syndrome (HHS), a telomere biology disorder, who developed severe chronic enterocolitis with inflammatory bowel disease‐like features. Vedolizumab led to improvement in stool frequency, reduced fecal calprotectin, and clinical remission without infectious complications.
Yasutaka Chiba, Manabu Takahashi, Taro Yoshida, Seiya Tagane, Takeshi Shiohata, Shoko Miura, Manami Akasaka   +6 more
wiley   +1 more source

Telomeres and atherosclerosis.

Cardiovascular journal of Africa, 2012
In humans and other multicellular organisms that have an extended lifespan, the leading causes of death are atherosclerotic cardiovascular disease and cancer. Experimental and clinical evidence indicates that these age-related disorders are linked through dysregulation of telomere homeostasis.
Khan, Sajidah, NAIDOO, DATSHANA P, Chuturgoon, Anil A   +2 more
openaire   +2 more sources

Nail Disorders in Systemic Conditions

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley   +1 more source

ALTered telomeres in response to telomere dysfunction [PDF]

Cell Cycle, 2011
Marie Eve, Brault, Chantal, Autexier
openaire   +2 more sources