Results 141 to 150 of about 59,567 (314)
Telomeres and telomerase in endometrial cancer and hyperplasia
Introduction The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer. Material and methods Total RNA and DNA were isolated from endometrium samples of 117 patients.
Anna Pańczyszyn +4 more
core +1 more source
Food Bioengineering, EarlyView.ABSTRACT This study rigorously assessed the impact of folic acid‐fortified whole wheat products on mitigating mild liver injury caused by prolonged excessive folic acid consumption, improving folic acid bioavailability, and enhancing spatial cognitive functions in mice over a 48‐day intervention period.
Yan Qi +3 more
wiley +1 more source
Advanced Genetics, Volume 6, Issue 1, March 2025.This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley +1 more source
Journal of Cell Science, 2012 The linearity of chromosomes creates two major problems for eukaryotic cells: the end-replication problem and the end-protection problem. The end-replication problem stems from the inherent inability of the replication machinery to fully duplicate linear templates.
openaire +3 more sources
High prevalence of short telomeres in idiopathic porto-sinusoidal vascular disorder. [PDF]
BACKGROUND Telomeres prevent damage to coding DNA as end-nucleotides are lost during mitosis. Mutations in telomere maintenance genes cause excessive telomere shortening, a condition known as short telomere syndrome (STS).
Coukos, Alexander +25 more
core +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
ALTered telomeres in response to telomere dysfunction [PDF]
Cell Cycle, 2011 Marie Eve, Brault, Chantal, Autexier
openaire +2 more sources
Telomere and Telomerase Biology
, 2014 Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special structures that cap chromosome ends to prevent degradation by nucleolytic attack and to distinguish chromosome termini from DNA double-strand breaks.
Calado, R. T. +15 more
core +1 more source
International Journal of Cancer, EarlyView.Acute myeloid leukemia adult cases often appear cytogenetically normal when analyzed with conventional karyotyping. However, acquired structural variants may escape routine detection. Here, optical genome mapping detected diverse genomic alterations in nearly half of the analyzed cytogenetically normal cases.
Tuuni Turtinen +7 more
wiley +1 more source