Results 121 to 130 of about 47,118 (266)

Biological age in the meta omics era: Integrating physical activity, sleep, and diet to reshape paths of healthy ageing

iMetaOmics, EarlyView.
Biological age provides a translational endpoint linking modifiable lifestyle behaviors—physical activity, sleep, and diet—to multi‐omics changes and downstream clinical outcomes. Integrating multiple ageing clocks with inflammatory, metabolic, and oxidative pathways supports reproducible, intervention‐ready strategies to slow ageing and extend ...
Yanwei You, Yicong Cui, Yuquan Chen, Jiarong He, Dongmin Wang, Danijela Gasevic, Xifeng Wu, Steve Horvath, Mingming Zhang, Xindong Ma   +9 more
wiley   +1 more source

Telomeres and telomere dysfunctions

Reviews in Biological and Biomedical Sciences, 2018
Elena Georgiana Dobre, Sorina Dinescu, Marieta Costache   +2 more
openaire   +1 more source

Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium

iMeta, EarlyView.
Bazi Bushen Capsule (BZBS) mitigates age‐related endometrial dysfunction by activating AMPK − SIRT3 signaling. Luteolin, a key bioactive component, restores mitochondrial homeostasis via PINK1/Parkin−mediated mitophagy and Drp1 inhibition, improving endometrial function and fertility potential.
Shangqi Li, Feng Deng, Hongjuan Niu, Meng Li, Zeyang Lin, Jiayi Ma, Yue Wang, Yueqi Leng, Yunlong Hou, Wenwen Cui, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +13 more
wiley   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Half a Century of Per‐ and Polyfluoroalkyl Substances in Northern Gannet Eggs: Impact of Regulations

Journal of Applied Toxicology, EarlyView.
ABSTRACT Per‐ and polyfluoroalkyl substances (PFAS), known as “forever chemicals”, are persistent organic pollutants that have been widely used in the industry across the globe for many decades. Their chemical stability, bioaccumulation, and toxicity pose major environmental and health risks. This study examines temporal trends in the concentrations of
Anaïs Fournier, Anaïs Kerric, Raphaël A. Lavoie   +2 more
wiley   +1 more source

Nail Disorders in Systemic Conditions

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail findings in children can be indicative of an underlying systemic disease. Many of these findings are seen in multiple entities and are not specific to one disease. The importance of specifically examining for these nail changes cannot be overstated.
Jane Sanders Bellet
wiley   +1 more source

Addendum: Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1. [PDF]

Nat Commun
Smoom R, May CL, Ortiz V, Tigue M, Kolev HM, Rowe M, Reizel Y, Morgan A, Egyes N, Lichtental D, Skordalakes E, Kaestner KH, Tzfati Y.   +12 more
europepmc   +1 more source

Nail Lichen Planus in Children ‐ Epidemiology, Pathogenesis, Clinical Presentation, and Treatment

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail lichen planus (NLP) is a chronic inflammatory disorder that, while rare in children compared to adults, represents a significant cause of pediatric nail dystrophy that requires early recognition to prevent permanent scarring and nail loss.
Francesca Pampaloni, Matilde Iorizzo
wiley   +1 more source

Telomere-driven dysfunctional changes in gynecological cancers: mechanistic insights, biomarker potential, and therapeutic targeting. [PDF]

Front Cell Dev Biol
Afolabi OA, Alade TA, Olaniyi KS, Adeyemi MO, Oladepo S, Gbadero JO, Oyedokun MD, Olayemi SB, Akindele BM, Oladipo AA, Adegbola CA, Oghenetega OB, Akinsanya SY, Sotunsa J, Ogunleye OD, Lasisi-Sholola AS, Owolabi VP, Adewale O, Adewale J, Oke DA, Adelani Abdur-Rahman H, Oyedokun PA.   +21 more
europepmc   +1 more source