Results 71 to 80 of about 367,883 (311)

BRAFV600E and TERT promoter mutations and their impact on recurrent papillary thyroid carcinoma progression

Endocrine Connections
Papillary thyroid carcinoma (PTC) is the most prevalent histological subtype of thyroid cancer. However, it remains unclear whether BRAFV600E, TERT promoter (TERT-p), and certain pathological markers, such as loss of polarity/loss of cell cohesiveness ...
Nguyen Thi Nhung, Van Dong Hoang, Zhanna Mussazhanova, Hirokazu Kurohama, Le Ngoc Ha, Katsuya Matsuda, Van Phu Thang Nguyen, Ngo Thi Minh Hanh, Thi Ngoc Anh Nguyen, Masahiro Nakashima   +9 more
doaj   +1 more source

Thyroid carcinoma‐featured telomerase activation and telomere maintenance: Biology and translational/clinical significance

Clinical and Translational Medicine, 2022
Background Telomerase is a ribonucleoprotein complex consisting of a catalytic component telomerase reverse transcriptase (TERT), internal RNA template and other co‐factors, and its essential function is to synthesize telomeric DNA, repetitive TTAGGG ...
Xiaotian Yuan, Huiyang Yuan, Ning Zhang, Tiantian Liu, Dawei Xu   +4 more
doaj   +1 more source

Functionalization of Pyrene To Prepare Luminescent Materials—Typical Examples of Synthetic Methodology [PDF]

, 2016
Pyrene-based π-conjugated materials are considered to be an ideal organic electro-luminescence material for application in semiconductor devices, such as organic light-emitting diodes (OLEDs), organic field-effect transistors (OFETs) and organic ...
Ajami, Alfonso, Baldo, Barton, Batsanov, Beaupré, Beller, Bernhardt, Bolm, Cao, Caronna, Caronna, Casas-Solvas, Cerfontain, Chang, Chen, Chen, Cheng, Chercka, Coventry, Crawford, Dewar, Duong, Eliseeva, Espinosa, Feng, Feng, Feng, Feng, Feng, Feng, Feng, Figueira-Duarte, Figueira-Duarte, Figueira-Duarte, Fihri, Fuchibe, Gao, García, Gonell, Grandbois, Hashmi, Hong, Hu, Hu, Hu, Hu, Hu, Hu, Hu, Hu, Hu, Hu, Ibáñez, Inoue, Irvine, Ito, Iwasaki, Jeon, Ji, Ji, Jiang, Jiao, Kamtekar, Katz, Kawano, Keller, Kim, Kim, King, Klauk, Kohl, Kulisic, Kumar, Lambert, Lee, Lee, Letizia, Li, Li, Liu, Malashikhin, Marco, Mateo-Alonso, Miyasaka, Miyaura, Miyaura, Miyazawa, Miyazawa, Mkhalid, Moorthy, More, More, Moulin, Ni, Niko, Oberender, Olah, Olah, Paul, Qiao, Rajca, Rajca, Rathore, Reineke, Schmidt-Mende, Sonar, Sun, Sun, Szaciłowski, Tan, Tanaka, Tang, Tao, Tashiro, Thomas, Trattnig, Trattnig, Valdés, Venkataramana, Verbiest, Verbiest, Visbal, Vollmann, Xiao, Xu, Yamato, Yamato, Yamato, Yamato, Yamato, Yua, Zak, Zhang, Zhang, Zhao, Zwijnenburg, Zöphel, Zöphel, Zöphel   +139 more
core   +2 more sources

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation

, 2014
A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3–sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step.
Despiau, Carole F., Dominey, Andrew P., Harrowven, David C., Linclau, Bruno   +3 more
core   +2 more sources

In Situ Constructed Magnetic Core‐Shell Hydrogen‐Bonded Organic Framework‐on‐Metal–Organic Framework Structure: an Efficient Catalyst for Peroxymonosulfate Activation

Advanced Functional Materials, EarlyView.
In this work, a magnetic core‐shell catalyst (HOF‐on‐Fe3O4/ZIF‐67) is successfully synthesized, consisting of a metal–organic framework (ZIF‐67) with magnetic Fe3O4 as the core and a porous hydrogen‐bonded organic framework (HOF) as the shell. The catalyst efficiently activated peroxymonosulfate, resulting in rapid and effective removal of water ...
Yingying Du, Chenhui Ding, Chao Deng, Susanta Banerjee, Seema Agarwal   +4 more
wiley   +1 more source

Accumulation of TERT in mitochondria exerts two opposing effects on apoptosis

FEBS Open Bio, 2023
Telomerase reverse transcriptase (TERT) is a protein that catalyzes the reverse transcription of telomere elongation. TERT is also expected to play a non‐canonical role beyond telomere lengthening since it localizes not only in the nucleus but also in ...
Hiroshi Ebata, Tomohiro Shima, Ryo Iizuka, Sotaro Uemura   +3 more
doaj   +1 more source

Synthesis and biological evaluation of novel PDMP analogues [PDF]

, 2006
A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward ...
Boldin-Adamsky, Swetlana, Busson, Roger, Futerman, Anthony H, Hillaert, Ulrik, Rozenski, Jef, Van Calenbergh, Serge   +5 more
core   +1 more source

Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions

Advanced Functional Materials, EarlyView.
This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian, Jingkai Lin, Zhihao Tian, Selusiwe Ncube, Huayang Zhang, Emiliano Cortés, Hongqi Sun, Shaobin Wang   +7 more
wiley   +1 more source

Oncolytic Adenovirus RCA-TERT-Ad35 Carrying Human Telomerase Reverse Transcriptase Promoter Targets Breast Cancer Stem Cells

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the role of oncolytic adenovirus RCA-TERT-Ad35 carrying human telomerase reverse transcriptase promoter in targeting breast cancer stem cells.
WANG Weichuan, CHEN Lulu, QUAN Xianglan, LI Ying, JIN Yongmin, JIN Wenbiao, YU Kexin, ZHANG Songnan   +7 more
doaj   +1 more source