Results 31 to 40 of about 203,484 (292)
Jurnal Medik VeterinerHepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide, while currently available first-line therapies are often constrained by systemic toxicity, resistance, and limited single-target mechanisms.
Aulanni'am Aulanni'am +10 more
doaj +1 more source
Архивъ внутренней медициныGiven their ubiquitous progressive nature and unfavorable prognosis, interstitial lung diseases (ILD), especially such common variants as idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP), rightly attract considerable attention ...
E. E. Arkhangelskaya +5 more
doaj +1 more source
Expression of telomerase reverse transcriptase in peripheral T‐cell lymphoma
Cancer Medicine, 2021 Telomere length is maintained by the activation of telomerase, which causes continuous cell division and proliferation in many carcinomas. A catalytic reverse transcriptase protein (TERT) encoded by the TERT gene plays a critical role in the activation ...
Fumiko Arakawa +13 more
doaj +1 more source
Frontiers in Bioscience-LandmarkBackground: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li +7 more
doaj +1 more source
Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract
Journal of Experimental Pharmacology, 2021 Agung H Karsono,1 Olivia M Tandrasasmita,1 Guntur Berlian,1 Raymond R Tjandrawinata2,3 1Section of Molecular Pharmacology, Research Innovation and Invention, Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Cikarang, West Java 17550, Indonesia ...
Karsono AH +3 more
doaj
, 2017 Introduction: Mutation in the core promoter of the telomerase reverse transcriptase (TERT) gene was determined to be a frequent event in malignant melanoma and other cancers. However, the role of TERT promoter mutation in hepatocellular carcinomas (HCCs)
許輝吉;鄭永銘;袁瑞晃;賴寶蓮 +1 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Role of ATRX and TERT Expressions in Determining Aggressiveness of Neuroblastoma
Journal of Behçet Uz Children's HospitalObjective: Neuroblastoma (NB) is a common childhood tumour, affecting telomerase enzyme activity. Expression of telomerase reverse transcriptase (TERT) protein is crucial for the fuınctioning of telomerase activity, but its association with risk ...
Murat Tuncel +8 more
doaj +1 more source
Mutations in Non–Small Cell Lung Cancer: Clinicopathologic Features and Prognostic Implications
Clinical Medicine Insights: Oncology, 2023 Introduction: The associations between the clinical characteristics of non–small cell lung cancer (NSCLC) and mutations in telomerase reverse transcriptase ( TERT ) gene remain unclear.
Liu Yang +8 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source