Results 31 to 40 of about 130,112 (263)

Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant TERT promoter methylation, but not hot-spot mutations

Epigenetics, 2019
Telomere maintenance is a critical requirement for enabling replicative immortality and tumour development. Here, telomerase expression and activity, telomere length (TL) and potential regulatory factors that can underlie telomerase machinery alterations
Omid Fotouhi, Mehran Ghaderi, Na Wang, Jan Zedenius, Magnus Kjellman, Dawei Xu, C. Christofer Juhlin, Catharina Larsson   +7 more
doaj   +1 more source

Hyperpolarized δ-[1- 13C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma

Scientific Reports, 2023
TERT promoter mutations are a hallmark of glioblastoma (GBM). Accordingly, TERT and GABPB1, a subunit of the upstream mutant TERT promoter transcription factor GABP, are being considered as promising therapeutic targets in GBM.
Noriaki Minami, Donghyun Hong, Celine Taglang, Georgios Batsios, Anne Marie Gillespie, Pavithra Viswanath, Nicholas Stevers, Carter J. Barger, Joseph F. Costello, Sabrina M. Ronen   +9 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The Role of ATRX and TERT Expressions in Determining Aggressiveness of Neuroblastoma

Journal of Behçet Uz Children's Hospital
Objective: Neuroblastoma (NB) is a common childhood tumour, affecting telomerase enzyme activity. Expression of telomerase reverse transcriptase (TERT) protein is crucial for the fuınctioning of telomerase activity, but its association with risk ...
Murat Tuncel, Selen Kum Özşengezer, Gamze Sanlav, Deniz Kızmazoğlu, Safiye Aktaş, Zekiye Altun, Tekincan Çağrı Aktaş, Erdener Özer, Nur Olgun   +8 more
doaj   +1 more source

Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers

Molecular Oncology, 2020
Telomerase reverse transcriptase (TERT) is pathologically expressed in the vast majority of human cancers, but the epigenetic regulation of its expression is only beginning to be understood.
Teisha J. Rowland, Andrew J. Bonham, Thomas R. Cech   +2 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma

Cell Death and Disease, 2020
Hepatocellular carcinoma (HCC) has a high mortality rate and lacks an effective therapeutic target. Elevated expression of human telomerase reverse transcriptase (TERT) is an important hallmark in cancers, but the mechanism by which TERT is activated ...
Wenbin Li, Yue Yan, Zongheng Zheng, Qiaohua Zhu, Qian Long, Silei Sui, Meihua Luo, Miao Chen, Yizhuo Li, Yijun Hua, Wuguo Deng, Renchun Lai, Liren Li   +12 more
doaj   +1 more source

Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness

Molecular Oncology, 2021
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described.
Manuel Bernabé‐García, Elena Martínez‐Balsalobre, Diana García‐Moreno, Jesús García‐Castillo, Beatriz Revilla‐Nuin, Elena Blanco‐Alcaina, Victoriano Mulero, Francisca Alcaraz‐Pérez, María L. Cayuela   +8 more
doaj   +1 more source

Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions

Advanced Functional Materials, EarlyView.
This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian, Jingkai Lin, Zhihao Tian, Selusiwe Ncube, Huayang Zhang, Emiliano Cortés, Hongqi Sun, Shaobin Wang   +7 more
wiley   +1 more source

A telomerase with novel non-canonical roles: TERT controls cellular aggregation and tissue size in Dictyostelium.

PLoS Genetics, 2019
Telomerase, particularly its main subunit, the reverse transcriptase, TERT, prevents DNA erosion during eukaryotic chromosomal replication, but also has poorly understood non-canonical functions. Here, in the model social amoeba Dictyostelium discoideum,
Nasna Nassir, Geoffrey J Hyde, Ramamurthy Baskar   +2 more
doaj   +1 more source