Results 21 to 30 of about 203,484 (292)

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression [PDF]

open access: yes, 2013
Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the ...
Hayes, R B   +361 more
core   +2 more sources

Expression of tert Prevents ALT in Zebrafish Brain Tumors

open access: yesFrontiers in Cell and Developmental Biology, 2020
The activation of a telomere maintenance mechanism (TMM) is an essential step in cancer progression to escape replicative senescence and apoptosis.
Aurora Irene Idilli   +7 more
doaj   +1 more source

Di-μ-tert-butanolato-bis[bis(η5-cyclopentadienyl) erbium(III)] [PDF]

open access: yes, 2008
In the centrosymmetric title compound, [Er2(C5H5)4(C4H9O)2], each Er atom is in a distorted tetrahedral coordination environment, coordinated by two cyclopentadienyl rings and two tert-butoxy groups, forming a dimeric complex bridged through the tert ...
Sandro Pagano   +3 more
core   +1 more source

Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk. [PDF]

open access: yes, 2014
Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT and CLPTM1L, but no such association has been reported with endometrial cancer.
Olson, J.E.   +479 more
core   +2 more sources

tert-Butylaminium phosphite [PDF]

open access: yesActa Crystallographica Section E Structure Reports Online, 2009
In the title compound, C(4)H(12)N(+)·H(2)PO(3) (-), the components are linked by inter-molecular N-H⋯O and O-H⋯O hydrogen bonds, resulting in a two-dimensional framework.
Jian, Fang-Fang, Zhang, Jun-Li
openaire   +3 more sources

Translational practice of fluorescence in situ hybridisation to identify neuroblastic tumours with TERT rearrangements

open access: yesThe Journal of Pathology: Clinical Research, 2023
Recently, telomerase reverse transcriptase (TERT) gene rearrangements have been identified in neuroblastoma (NB), the typical pathological type of neuroblastic tumours (NTs); however, the prevalence of TERT rearrangements in other types of NT remains ...
Yongbo Yu   +12 more
doaj   +1 more source

TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities.

open access: yesPLoS ONE, 2023
Telomerase reverse transcriptase (TERT) promoter mutations occur frequently in cancer, have been associated with increased TERT expression and cell proliferation, and could potentially influence therapeutic regimens for melanoma.
Christina Katharina Kuhn   +10 more
doaj   +1 more source

Histoprognostic classification and grading of meningiomas in the era of precision medicine. Routine applicability for the Algerian pathologist and therapeutic implications. [PDF]

open access: yesBatna Journal of Medical Sciences
Meningiomas are the most common primary tumors of the central nervous system (CNS). Their histopathological classification and prognostic stratification have undergone major revisions following the introduction of the first molecular biomarkers—TERT ...
Mohamed GUERMI   +2 more
doaj   +1 more source

Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review

open access: yesFrontiers in Endocrinology, 2020
Telomerase reverse transcriptase (TERT) is the catalytic subunit of the enzyme telomerase and is essential for telomerase activity. Upregulation of TERT expression and resulting telomerase activity occurs in the large majority of malignancies, including ...
Brittany A. McKelvey   +5 more
doaj   +1 more source

In vitro Differentiation of Human TERT-Transfected Multi-Lineage Progenitor Cells (MLPC) into Immortalized Hepatocyte-Like Cells

open access: yesHepatic Medicine: Evidence and Research, 2020
Daniel P Collins, 1 Joel H Hapke, 1 Rajagopal N Aravalli, 2 Clifford J Steer 3, 4 1Cytomedical Design Group, LLC, Saint Paul, MN 55127, USA; 2Department of Electrical and Computer Engineering, College of Science and Engineering, University of Minnesota,
Collins DP   +3 more
doaj  

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