Results 21 to 30 of about 367,883 (311)

Structural basis of template-boundary definition in Tetrahymena telomerase. [PDF]

, 2015
Telomerase is required to maintain repetitive G-rich telomeric DNA sequences at chromosome ends. To do so, the telomerase reverse transcriptase (TERT) subunit reiteratively uses a small region of the integral telomerase RNA (TER) as a template.
Akiyama, Ben M, Jansson, Linnea I, Lu, Cheng, Ooms, Alexandra, Rubin, Seth M, Stone, Michael D   +5 more
core   +2 more sources

Translational practice of fluorescence in situ hybridisation to identify neuroblastic tumours with TERT rearrangements

The Journal of Pathology: Clinical Research, 2023
Recently, telomerase reverse transcriptase (TERT) gene rearrangements have been identified in neuroblastoma (NB), the typical pathological type of neuroblastic tumours (NTs); however, the prevalence of TERT rearrangements in other types of NT remains ...
Yongbo Yu, Meng Zhang, Xingfeng Yao, Xiaoxing Guan, Chao Jia, Ping Chu, Ruqian Zhang, Yeran Yang, Yaqiong Jin, Huanmin Wang, Xin Ni, Lejian He, Yongli Guo   +12 more
doaj   +1 more source

Synthesis and Structure of 1,2-Dimethylene[2.10]metacyclophane and Its Conversion into Chiral [10]Benzenometacyclophanes: Synthesis and Structure of 1,2-Dimethylene[2.10]metacyclophane and Its Conversion into Chiral [10]Benzenometacyclophanes [PDF]

, 2017
Bromination of 5,21-di-tert-butyl-8,24-dimethoxy-1,2-dimethyl[2.10]metacyclophan-1-ene (MCP-1-ene; 1) with benzyltrimethylammonium tribromide exclusively afforded 1,2-bis(bromomethyl)-5,21-di-tert-butyl-8,24-dimethoxy[2.10]MCP-1-ene (2). Debromination of
Akther, Thamina, Islam, Md Monarul, Islam, Md. Monarul, Matsumoto, Taisuke, Redshaw, Carl, Tanaka, Junji, Thuery, Pierre, Thuéry, Pierre, Yamato, Takehiko   +8 more
core   +3 more sources

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter. [PDF]

, 2016
Telomere and Telomerase have recently been explored as anti-aging and anti-cancer drug targets with only limited success. Previously we showed that the Chinese herbal medicine Tianshengyuan-1 (TSY-1), an agent used to treat bone marrow deficiency, has a ...
Chow, Michelle, Jin, Yusheng, Li, Yawei, Qin, Xiaotian, Rao, Jianyu, Santiskulvong, Chintda, Vu, Victor, Yu, Weibo, Zeng, Gang, Zhang, Zuofeng   +9 more
core   +2 more sources

Three protected tetrapeptides [PDF]

, 1996
The structures of three protected tetrapeptides, containing the Boc-Gly-Gly-Phe-X-OMe chain, tert-butoxycarbonyl-glycy-glycl-phenylalanine-leucine methyl ester dihydrate, Boc-Gly-Gly-L-Phe-D-Leu-OMe, C25H38N4O7·2H2O, tert-butoxycarbonyl-glycy-glycl ...
Casalone, Gianluigi, Fenude, Emma
core   +1 more source

Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review

Frontiers in Endocrinology, 2020
Telomerase reverse transcriptase (TERT) is the catalytic subunit of the enzyme telomerase and is essential for telomerase activity. Upregulation of TERT expression and resulting telomerase activity occurs in the large majority of malignancies, including ...
Brittany A. McKelvey, Brittany A. McKelvey, Christopher B. Umbricht, Christopher B. Umbricht, Christopher B. Umbricht, Martha A. Zeiger   +5 more
doaj   +1 more source

Mitochondrial TERT enhances mitochondria functions in vivo by protecting mitochondrial DNA integrity from oxidative damage : meeting abstract [PDF]

, 2009
Mitochondria are essential for respiration and oxidative phosphorylation. Mitochondrial dysfunction due to aging processes is involved in pathologies and pathogenesis of a series of cardiovascular disorders. New results accumulate showing that the enzyme
Altschmied, Joachim, Brandt, Ulrich, Büchner, Nicole, Dröse, Stefan, Haendeler, Judith, Jakob, Sascha   +5 more
core   +1 more source

TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities.

PLoS ONE, 2023
Telomerase reverse transcriptase (TERT) promoter mutations occur frequently in cancer, have been associated with increased TERT expression and cell proliferation, and could potentially influence therapeutic regimens for melanoma.
Christina Katharina Kuhn, Jaroslawna Meister, Sophia Kreft, Mathias Stiller, Sven-Holger Puppel, Anne Zaremba, Björn Scheffler, Vivien Ullrich, Torsten Schöneberg, Dirk Schadendorf, Susanne Horn   +10 more
doaj   +1 more source

Vanadium(v) phenolate complexes for ring opening homo- and co-polymerisation of ε-caprolactone, L-lactide and rac-lactide [PDF]

, 2015
The vanadyl complexes [VO(OtBu)L¹ ] (1) and {[VO(OiPr)]₂ (μ-p-L²ᵖ)} (2) {[VO(OR)]₂ (μ-p-L²ᵐ )} (R = iPr 3, tBu 4) have been prepared from [VO(OR)₃ ] (R = nPr, iPr or tBu) and the respective phenol, namely 2,2′-ethylidenebis(4,6-di-tert-butylphenol) (L¹ ...
Al-Khafaji, Yahya, Dan, Yi, Elsegood, Mark R. J., Ge, Feijie, Jiang, Long, Prior, Timothy J., Redshaw, Carl   +6 more
core   +2 more sources

(R)-N-{2-tert-Butyl-2-[(R)-tert-butylsulfonamido]ethylidene}-tert-butanesulfonamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
The title compound, C(14)H(30)N(2)O(2)S(2), is the product of the monoaddition reaction of tert-butyl magnesium chloride with bis-[(R)-N-tert-butanesulfinyl]ethanediimine. There are two almost identical mol-ecules in the asymmetric unit, the mol-ecular conformation of which is stabilized by an intra-molecular N-H⋯N hydrogen bond.
Cong-Bin Fan, Xiao-Xia Sun, Yu Hu
openaire   +3 more sources