Results 21 to 30 of about 130,112 (263)

TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities.

PLoS ONE, 2023
Telomerase reverse transcriptase (TERT) promoter mutations occur frequently in cancer, have been associated with increased TERT expression and cell proliferation, and could potentially influence therapeutic regimens for melanoma.
Christina Katharina Kuhn, Jaroslawna Meister, Sophia Kreft, Mathias Stiller, Sven-Holger Puppel, Anne Zaremba, Björn Scheffler, Vivien Ullrich, Torsten Schöneberg, Dirk Schadendorf, Susanne Horn   +10 more
doaj   +1 more source

Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review

Frontiers in Endocrinology, 2020
Telomerase reverse transcriptase (TERT) is the catalytic subunit of the enzyme telomerase and is essential for telomerase activity. Upregulation of TERT expression and resulting telomerase activity occurs in the large majority of malignancies, including ...
Brittany A. McKelvey, Brittany A. McKelvey, Christopher B. Umbricht, Christopher B. Umbricht, Christopher B. Umbricht, Martha A. Zeiger   +5 more
doaj   +1 more source

Expression of telomerase reverse transcriptase in peripheral T‐cell lymphoma

Cancer Medicine, 2021
Telomere length is maintained by the activation of telomerase, which causes continuous cell division and proliferation in many carcinomas. A catalytic reverse transcriptase protein (TERT) encoded by the TERT gene plays a critical role in the activation ...
Fumiko Arakawa, Hiroaki Miyoshi, Noriaki Yoshida, Kazutaka Nakashima, Yosaku Watatani, Takuya Furuta, Kyohei Yamada, Mayuko Moritsubo, Mai Takeuchi, Eriko Yanagida, Yasumasa Shimasaki, Kei Kohno, Keisuke Kataoka, Koichi Ohshima   +13 more
doaj   +1 more source

In vitro Differentiation of Human TERT-Transfected Multi-Lineage Progenitor Cells (MLPC) into Immortalized Hepatocyte-Like Cells

Hepatic Medicine: Evidence and Research, 2020
Daniel P Collins, 1 Joel H Hapke, 1 Rajagopal N Aravalli, 2 Clifford J Steer 3, 4 1Cytomedical Design Group, LLC, Saint Paul, MN 55127, USA; 2Department of Electrical and Computer Engineering, College of Science and Engineering, University of Minnesota,
Collins DP, Hapke JH, Aravalli RN, Steer CJ   +3 more
doaj  

Mutations in Non–Small Cell Lung Cancer: Clinicopathologic Features and Prognostic Implications

Clinical Medicine Insights: Oncology, 2023
Introduction: The associations between the clinical characteristics of non–small cell lung cancer (NSCLC) and mutations in telomerase reverse transcriptase ( TERT ) gene remain unclear.
Liu Yang, Meng Wang, Na Li, Lu-Da Yan, Wen Zhou, Zhi-Qiong Yu, Xiao-Chun Peng, Jun Cai, Yong-Hua Yang   +8 more
doaj   +1 more source

Idiopathic Pulmonary Fibrosis and Hypersensitive Pneumonitis: A Fresh View on The Role of Genetic and Epigenetic Factors in The Development and Course of Diseases

Архивъ внутренней медицины
Given their ubiquitous progressive nature and unfavorable prognosis, interstitial lung diseases (ILD), especially such common variants as idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP), rightly attract considerable attention ...
E. E. Arkhangelskaya, S. V. Lyamina, E. O. Kozhevnikova, I. V. Kozlova, T. G. Shapovalova, G. L. Yurenev   +5 more
doaj   +1 more source

Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract

Journal of Experimental Pharmacology, 2021
Agung H Karsono,1 Olivia M Tandrasasmita,1 Guntur Berlian,1 Raymond R Tjandrawinata2,3 1Section of Molecular Pharmacology, Research Innovation and Invention, Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Cikarang, West Java 17550, Indonesia ...
Karsono AH, Tandrasasmita OM, Berlian G, Tjandrawinata RR   +3 more
doaj  

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms. [PDF]

PLoS Computational Biology, 2014
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though
Alan E Bilsland, Katrina Stevenson, Yu Liu, Stacey Hoare, Claire J Cairney, Jon Roffey, W Nicol Keith   +6 more
doaj   +1 more source

Downregulated METTL3 Accumulates TERT Expression that Promote the Progression of Ovarian Endometriosis

Frontiers in Bioscience-Landmark
Background: Endometriosis is a complicated and enigmatic disease that significantly diminishes the quality of life for women affected by this condition.
Fang Li, Hua Tao, Yini Wei, Ru Meng, Yushan Li, Lifang Nie, Yu Zhang, Jinjun Chang   +7 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source