Prognostic value of somatic mutation testing and different methods of treatment of low-risk differentiated thyroid cancer [PDF]
Эндокринная хирургия, 2019 Background: Using molecular testing for prediction the course of the disease could possibly help doctors in making therapeutic decisions about the management of patients, because it remains controversial issues in low-risk differentiated thyroid cancer ...
Vera A. Kachko +2 more
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tert-Butylaminium phosphite [PDF]
Acta Crystallographica Section E Structure Reports Online, 2009 In the title compound, C(4)H(12)N(+)·H(2)PO(3) (-), the components are linked by inter-molecular N-H⋯O and O-H⋯O hydrogen bonds, resulting in a two-dimensional framework.
Jian, Fang-Fang, Zhang, Jun-Li
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Mechanisms of Reactivation and Its Interaction with [PDF]
Endocrinology and Metabolism, 2020 The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations.
Young Shin Song, Young Joo Park
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Somatic mutation testing: the role in differential diagnosis of thyroid neoplasms [PDF]
Эндокринная хирургия, 2019 Background: In the preoperative diagnosis of thyroid tumors the cytological examination of the material of fine needle aspiration biopsy is the gold standard and serves as the basis for planning of treatment strategy.
Vera A. Kachko +5 more
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Expression of tert Prevents ALT in Zebrafish Brain Tumors
Frontiers in Cell and Developmental Biology, 2020 The activation of a telomere maintenance mechanism (TMM) is an essential step in cancer progression to escape replicative senescence and apoptosis.
Aurora Irene Idilli +7 more
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Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells [PDF]
, 2016 open7siBesides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions.
Celeghin, Andrea +6 more
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Cancer-associated TERT promoter mutations abrogate telomerase silencing. [PDF]
, 2015 Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established.
Boyle, John +5 more
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Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications [PDF]
, 2018 The Epstein-Barr virus (EBV) is a ubiquitous human \u3b3-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies.
Celeghin, Andrea +4 more
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Synthesis of Enantiopure tert-Butanesulfinamide from tert-Butanesulfinyloxazolidinone [PDF]
The Journal of Organic Chemistry, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Qin, Yong +4 more
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The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients [PDF]
, 2018 Background: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable.
A Celeghin +62 more
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