Results 41 to 50 of about 80,065 (270)
Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng +10 more
wiley +2 more sources
EMBO Molecular Medicine, 2012 A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity.
Bruno Bernardes de Jesus +6 more
doaj +1 more source
Telomerase RNA function in recombinant Tetrahymena telomerase [PDF]
Genes & Development, 1999 Telomerase is a ribonucleoprotein reverse transcriptase specialized for use of a sequence within its integral RNA component as the template for DNA synthesis. Telomerase adds telomeric simple sequence repeats to single-stranded primers in vitro or chromosome ends in vivo.
J D, Licht, K, Collins
openaire +2 more sources
The association between telomerase activity and expression of its RNA component (hTR) in breast cancer patients: the importance of DNase treatment [PDF]
Telomerase is a ribonucleoprotein enzyme that compensates for the telomere length shortening which occurs during the cell cycle. Telomerase activity has been detected in most tumours but not in somatic cells.
حسینی اصل, سید سعید +5 more
core +1 more source
eLife, 2018 Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. We show here that telomerase expression using AAV9
Juan Manuel Povedano +8 more
doaj +1 more source
A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase [PDF]
Nature Structural & Molecular Biology, 2005 Telomerase maintains the simple sequence repeats at chromosome ends, protecting cells from genomic rearrangement, proliferative senescence and death. The telomerase reverse transcriptase (TERT) and telomerase RNA (TER) alone can assemble into active enzyme in a heterologous cell extract, but the physiological process of telomerase biogenesis is more ...
Ramadevi, Prathapam +3 more
openaire +2 more sources
Stem Cell Reports, 2014 The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency.
Maria Luigia De Bonis +2 more
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How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript
Biomedicines, 2022 Telomerase RNA has been uncovered as a component of the telomerase enzyme, which acts as a reverse transcriptase and maintains the length of telomeres in proliferated eukaryotic cells.
Maria Rubtsova, Olga Dontsova
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The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action
Cell Reports, 2018 Summary: Telomerase recruitment to telomeres and enzymatic processivity are mediated by TPP1, an essential component of telomere integrity and telomerase function.
Sherilyn Grill +2 more
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source