Results 51 to 60 of about 72,827 (301)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction
Cell Reports, 2015 Idiopathic pulmonary fibrosis (IPF) is a degenerative disease of the lungs with an average survival post-diagnosis of 2–3 years. New therapeutic targets and treatments are necessary.
Juan M. Povedano +4 more
doaj +1 more source
How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript
Biomedicines, 2022 Telomerase RNA has been uncovered as a component of the telomerase enzyme, which acts as a reverse transcriptase and maintains the length of telomeres in proliferated eukaryotic cells.
Maria Rubtsova, Olga Dontsova
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Nature Communications, 2018 Long non-coding RNA TERRAs are essential for telomere protection and telomere length maintenance. Here the authors report a role for TERRAs in telomeric heterochromatin formation by recruiting Polycomb Repressive Complex 2 to telomeres.
Juan J. Montero +5 more
doaj +1 more source
Human Telomerase RNA: Telomerase Component or More?
Biomolecules, 2020 Telomerase is a ribonucleoprotein complex that maintains the lengths of telomeres. Most studies of telomerase function have focused on the involvement of telomerase activation in the immortalization of cancer cells and cellular rejuvenation.
Maria Rubtsova, Olga Dontsova
doaj +1 more source
Cell proliferation in the presence of telomerase. [PDF]
PLoS ONE, 2009 BACKGROUND: Telomerase, which is active early in development and later in stem and germline cells, is also active in the majority of human cancers. One of the known functions of telomerase is to extend the ends of linear chromosomes, countering their ...
Krastan B Blagoev
doaj +1 more source
CRISPR-based m6A modification and its potential applications in telomerase regulation
Frontiers in Cell and Developmental Biology, 2023 Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m6A epigenetic modification plays an important role in the regulation of telomerase activity.
Mingliang Yi +9 more
doaj +1 more source
Effect of chemotherapeutic drugs on telomere length and telomerase activity [PDF]
, 2020 Telomeres are specialized nucleoproteic complexes localized at the ends of eukaryotic chromosomes, that maintain their stability and integrity. They protect chromosome ends from fusion and from being recognized as sites of DNA damage, i.e., they ...
Bolzán, Alejandro Daniel
core
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source