Results 71 to 80 of about 72,827 (301)
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction
Advanced Science, EarlyView.This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng +12 more
wiley +1 more source
Current Insights to Regulation and Role of Telomerase in Human Diseases
Antioxidants, 2017 The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells.
Mert Burak Ozturk +2 more
doaj +1 more source
SMN and coilin negatively regulate dyskerin association with telomerase RNA
Biology Open, 2016 Telomerase is a ribonucleoprotein comprising telomerase RNA and associated proteins. The formation of the telomerase holoenzyme takes place in the Cajal body (CB), a subnuclear domain that participates in the formation of ribonucleoproteins.
Aaron R. Poole, Michael D. Hebert
doaj +1 more source
Telomerase-immortalized esophageal fibroblast cell line characterization.
, 2016 (a) FEE4-T and BEF-T exhibit spindle-like morphology. (b) Growth curves of telomerase-immortalized fibroblasts and primary cultures.
Xi Zhang (83736) +9 more
core +1 more source
Telomeres, Telomerase, and Cancer [PDF]
New England Journal of Medicine, 2000 What accounts for the ability of cancer cells to proliferate in a manner that is out of control, whereas normal cells die after 40 to 60 cycles of replication?
openaire +3 more sources
Arthritis &Rheumatology, EarlyView.Objective Dermal systemic sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with long noncoding RNA (lncRNA) H19 highlighted as the most up‐regulated RNA in their cargo compared with healthy controls (HCs). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz +3 more
wiley +1 more source
Telomerase Regulation: A Role for Epigenetics [PDF]
, 2021 Telomerase was first described by Greider and Blackburn in 1984, a discovery ultimately recognized by the Nobel Prize committee in 2009. The three decades following on from its discovery have been accompanied by an increased understanding of the ...
core
IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis
Arthritis &Rheumatology, Accepted Article.Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay +3 more
wiley +1 more source
The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation.
Newbold, RF, Kirkpatrick, KL, Mokbel, K
core +1 more source