Results 91 to 100 of about 80,065 (270)

The womb as the cradle of longevity: Perinatal origins of biological aging

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley   +1 more source

The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase

BMC Cancer, 2002
Background The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catalytic subunit of telomerase.
Schulze Wolfgang, Schostak Martin, Straub Bernd, Krause Hans, Müller Markus, Burger Angelika M, Schrader Mark, Lauke Heidrun, Miller Kurt   +8 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Relationship between Dyskerin Expression and Telomerase Activity in Human Breast Cancer

Cellular Oncology, 2008
The nucleolar protein dyskerin is involved in the modification of specific uridine residues to pseudouridine on ribosomal and small nuclear RNAs and in the stabilization of the telomerase RNA component (TERC).
Lorenzo Montanaro, Maria Calienni, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Stefano Pileri, Davide Treré, Massimo Derenzini   +7 more
doaj   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source

Targeting Telomerase in Cancer: Vaccine-Based Strategies, Clinical Evidence, and Synergy with Immunotherapy

Diseases
With each replication cycle, telomeres shorten. Telomerase can slow or reverse the rate of telomere shortening. In the era of cancer immunotherapy, telomerase is a promising tumor-associated antigen due to its widespread and specific expression in cancer
Stella Baliou, Manolis N. Tzatzarakis, Andreas G. Tsantes, Elena Vakonaki, Petros Ioannou, Michalis Kyriakakis, Eleftheria Hatzidaki, Iordanis Pelagiadis, Eftichia Stiakaki, Aristides Tsatsakis   +9 more
doaj   +1 more source

hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer [PDF]

Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization.
Kefah Mokbel, Mitchell, B, حسینی اصل, سید سعید, Morteza Atri, Blake, JRS, Elkak, AE, Meligonis, G, مدرسی, محمد حسین, مهدی پور, پروین, Parvin Mehdipour, عطری, مرتضی, سلحاب, محمد, Salhab, M, Newbold, RF, مکبل, کفاه, Mokbel, K, Mohamed Salhab, Saied Hosseini-Asl, Mohammad H Modarressi   +18 more
core   +1 more source

Sex‐Specific Early Life Corticosterone Stress‐Coping Capacity Is Linked to Mitochondrial Content and Telomere Maintenance

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Glucocorticoids are upregulated during acute challenges, contributing to maintenance of energy balance. However, if this upregulation exceeds a threshold or becomes chronic, it can lead to harmful effects. Investigating the factors behind between‐individual variation in the magnitude of the response to acute stress and how effectively ...
Mauricio Guillen‐Parra, Alberto Velando, Bibiana Montoya, Roxana Torres   +3 more
wiley   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma

The Laryngoscope, EarlyView.
We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano, Satoshi Kiyama, Takayuki Kyutoku, Masaru Yamashita   +3 more
wiley   +1 more source