Results 91 to 100 of about 78,599 (266)
Telomeres, Telomerase, and Cancer [PDF]
New England Journal of Medicine, 2000 What accounts for the ability of cancer cells to proliferate in a manner that is out of control, whereas normal cells die after 40 to 60 cycles of replication?
openaire +3 more sources
Effect of chemotherapeutic drugs on telomere length and telomerase activity [PDF]
, 2020 Telomeres are specialized nucleoproteic complexes localized at the ends of eukaryotic chromosomes, that maintain their stability and integrity. They protect chromosome ends from fusion and from being recognized as sites of DNA damage, i.e., they ...
Bolzán, Alejandro Daniel
core
The womb as the cradle of longevity: Perinatal origins of biological aging
International Journal of Gynecology &Obstetrics, EarlyView.Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley +1 more source
, 2017 Telomerase activity in cancer cells is commonly analyzed by a polymerase chain reaction (PCR)-based assay termed the telomeric repeat amplification protocol (TRAP).
Chen, Ying-Chieh;Huang, Fong-Chun;Lin, Jing-Jer +1 more
core +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi +11 more
wiley +1 more source
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
Telomerase-immortalized esophageal fibroblast cell line characterization.
, 2016 (a) FEE4-T and BEF-T exhibit spindle-like morphology. (b) Growth curves of telomerase-immortalized fibroblasts and primary cultures.
Xi Zhang (83736) +9 more
core +1 more source
Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma
The Laryngoscope, EarlyView.We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano +3 more
wiley +1 more source
DiseasesWith each replication cycle, telomeres shorten. Telomerase can slow or reverse the rate of telomere shortening. In the era of cancer immunotherapy, telomerase is a promising tumor-associated antigen due to its widespread and specific expression in cancer
Stella Baliou +9 more
doaj +1 more source