Results 81 to 90 of about 72,827 (301)

Hydroxyapatite promotes superior adhesion and proliferation of telomerase transformed keratocytes in comparison with inert plastic skirt materials used in leading contemporary keratoprostheses [PDF]

, 2005
Aim: Published clinical series suggest the osteoodontokeratoprosthesis (OOKP) may have a lower extrusion rate than current synthetic keratoprostheses. The OOKP is anchored in the eye wall by autologous tooth.
Futter, C., Futter, C.E., Sandeman, Susan; id_orcid, Mehta, J., Sandeman, S.R., Hing, K.A., Tanner, K.E., Allen, B.D.S., Faragher, Richard, Faragher, R.G.A.F., Allan, B.D.S, Mehta, J.S.   +11 more
core   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer [PDF]

Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization.
Kefah Mokbel, Mitchell, B, حسینی اصل, سید سعید, Morteza Atri, Blake, JRS, Elkak, AE, Meligonis, G, مدرسی, محمد حسین, مهدی پور, پروین, Parvin Mehdipour, عطری, مرتضی, سلحاب, محمد, Salhab, M, Newbold, RF, مکبل, کفاه, Mokbel, K, Mohamed Salhab, Saied Hosseini-Asl, Mohammad H Modarressi   +18 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces

eLife, 2016
Tightly controlled recruitment of telomerase, a low-abundance enzyme, to telomeres is essential for regulated telomere synthesis. Recent studies in human cells revealed that a patch of amino acids in the shelterin component TPP1, called the TEL-patch, is
Xichan Hu, Jinqiang Liu, Hyun-IK Jun, Jin-Kwang Kim, Feng Qiao   +4 more
doaj   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Renal fibroblasts are involved in fibrogenic changes in kidney fibrosis associated with dysfunctional telomeres

Experimental and Molecular Medicine
Tubulointerstitial fibrosis associated with chronic kidney disease (CKD) represents a global health care problem. We previously reported that short and dysfunctional telomeres lead to interstitial renal fibrosis; however, the cell-of-origin of kidney ...
Sarita Saraswati, Paula Martínez, Rosa Serrano, Diego Mejías, Osvaldo Graña-Castro, Ruth Álvarez Díaz, Maria A. Blasco   +6 more
doaj   +1 more source

The Regulation of Telomerase in Oncogenesis

Acta Naturae, 2009
The influence that the expression of the human (glial-derived neurotrophic factor (GDNF)) neurotrophic factor has on the morphology and proliferative activity of embryonic stem cells (SC) of a mouse with R1 lineage, as well as their ability to form embroid bodies (EB), has been studied.
Skvortzov, D., Rubzova, M., Zvereva, M., Kiselev, F., Donzova, O.   +4 more
openaire   +3 more sources

Characterization of the Interaction of Known G‐quadruplex Ligands With a Minimal i‐Motif Structure

Chemistry – A European Journal, EarlyView.
The destabilization of a minimal i‐Motif (iM) structure by TMPyP4 is driven by ligand recognition of one terminal iM structural domain. ABSTRACT Peculiar genomic regions are prone to evolve transiently from double‐helix DNA to noncanonical secondary structures in response to physiological stress.
Davide Auricchio, Marko Trajkovski, Janez Plavec, Claudia Sissi   +3 more
wiley   +1 more source