Results 111 to 120 of about 57,792 (238)
Nature CommunicationsMost cancers upregulate the telomere lengthening enzyme telomerase to achieve unlimited cell division. How chemotherapeutic nucleoside 6-thio-2’-deoxyguanosine (6-thio-dG) targets telomerase to inhibit telomere maintenance in cancer cells and tumors was ...
Samantha L. Sanford +13 more
doaj +1 more source
Israel Journal of Chemistry, Volume 66, Issue 5, September 2026.Bamboo‐derived cellulose suspensions were processed by high‐pressure homogenization and fabricated into porous scaffolds by directional freezing followed by freeze‐drying. Rheological characterization preceded scaffold fabrication, followed by mechanical testing and cell seeding evaluation.
Yarden Munish +8 more
wiley +1 more source
Telomere, telomerase and telomerase inhibitors
Bioorganic and Medicinal Chemistry Reports, 2020 Rahime Simsek, Yusuf Ataker
openaire +1 more source
Beraprost Attenuates Starvation‐Induced Apoptosis and Protects Feline Endothelial Cells
Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.This study established a feline endothelial cell starvation model to test the anti‐apoptotic effects of beraprost and its stereoisomers. Beraprost and beraprost‐314d reduced starvation‐induced apoptosis by inhibiting caspase‐3/7 activity and modulating Bax expression, while beraprost‐315d was less potent.
Takumi Matsuura +2 more
wiley +1 more source
The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics
Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree +18 more
wiley +1 more source
Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 568-577, September 2026.ABSTRACT Gene expression profiling (GEP) is being used with increasing frequency to characterise canine tumours, but canine samples are often not collected in a medium to preserve RNA. Cytology samples from human tumours have been shown to provide adequate RNA for GEP using NanoString nCounter technology, suggesting a similar approach might be viable ...
McKenzie Olsen +5 more
wiley +1 more source
Cuprous Ions Binding to Cytosine and Guanine Oligonucleotides
ChemBioChem, Volume 27, Issue 15, 14 August 2026.Using a comprehensive set of nucleic acid‐related molecules, from individual nucleobases to oligonucleotides, we demonstrate the selective binding of Cu+ to cytosine‐containing oligonucleotides. Contrary to guanine‐containing oligonucleotides, cytosine‐rich oligonucleotides form a Cu+‐complex with a clear near‐UV signature and are able to stop redox ...
Joana Pereira +3 more
wiley +1 more source
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, Volume 101, Issue 4, Page 1877-1903, August 2026.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Patient‐derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR‐based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function.
Julianne du Plessis, Aadilah Omar
wiley +1 more source