Results 131 to 140 of about 72,827 (301)
circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer
Cancer Science, EarlyView.circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang +4 more
wiley +1 more source
Diagnosis of Bladder Cancer Using Telomerase Activity in Voided Urine
, 2009 Background and purpose: Telomerase is an essential enzyme for cellular immortality and tumorigenesis. Reactivation of telomerase is associated with many primary cancers.
CHUEH, SHIH-CHIEH, 闕士傑
core
Imetelstat (GRN163L)--telomerase-based cancer therapy
, 2009 Telomeres and telomerase play essential roles in the regulation of the lifespan of human cells. While normal human somatic cells do not or only transiently express telomerase and therefore shorten their telomeres with each cell division, most human ...
Gabriela M. Baerlocher +5 more
core +1 more source
A Proposed Clinical Diagnostic Framework for Short Telomere Syndrome
Clinical Genetics, EarlyView.We propose a phenotype‐based diagnostic framework for short telomere syndrome that integrates age‐adjusted telomere length, phenotypic manifestations, and genetic findings, where available. The framework is intended to guide clinical evaluation, longitudinal surveillance, and individualized management while acknowledging limitations in current telomere
Andrew Courtwright +8 more
wiley +1 more source
The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics
Clinical Genetics, EarlyView.The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree +18 more
wiley +1 more source
Recent progress in human telomerase structure and its therapeutic targeting
Frontiers in Molecular BiosciencesMost cancer and stem cells activate telomerase to preserve critical genetic material during cell division. Telomerase is a reverse transcriptase ribonucleoprotein that adds telomeric repeats to chromosome ends, thus overcoming the end-replication problem.
Muaath Ebrahim Almansoori +5 more
doaj +1 more source
The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation
Scientific Reports, 2017 Telomerase activity is not readily detected in resting human T lymphocytes, however upon antigen presentation, telomerase is transiently upregulated. Presently, it is not known if telomerase activation is necessary for the proliferation of T cells or for
Ejun (Elijah) Huang +7 more
doaj +1 more source
To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy
European Journal of Haematology, EarlyView.ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino +16 more
wiley +1 more source
Telomeres and telomerase in endometrial cancer and hyperplasia
Introduction The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer. Material and methods Total RNA and DNA were isolated from endometrium samples of 117 patients.
Anna Pańczyszyn +4 more
core +1 more source
The FEBS Journal, EarlyView.Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong +6 more
wiley +1 more source