Results 141 to 150 of about 80,065 (270)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

microRNA‐145‐5p regulates P‐glycoprotein and breast cancer resistance protein in primary human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye, Enrrico Bloise, Nikola Ivanovski, Lubna Nadeem, Christopher Casciaro, Stephen G. Matthews   +5 more
wiley   +1 more source

ESTROGEN RECEPTOR BETA MEDIATES INDUCTION OF TELOMERASE ACTIVITY IN HUMAN PROSTATE CANCER.

, 2001
Signaling by steroid hormone receptor plays a pivotal role in all stages of prostate carcinogenesis. The characteristic age-related decrease in the ratio of androgens to estrogens in men may represent a contributing factor in prostate cancer development.
S Nanni, A Farsetti, M Narducci, F Moretti, A Grasselli, A Sacchi, L Della Pietra, A Pontecorvi   +7 more
core  

Telomere, telomerase and telomerase inhibitors

Bioorganic and Medicinal Chemistry Reports, 2020
Rahime Simsek, Yusuf Ataker
openaire   +1 more source

Intratumoral and Peritumoral Functional Connectivity Reveals Network‐Level Signatures of Glioma

MedComm, Volume 7, Issue 11, November 2026.
Using resting‐state fMRI in 306 glioma patients, this study maps individualized intra‐ and peritumoral functional networks. Novel metrics (RIFR, RPTR) quantify tumor‐related network remodeling, correlating with pathology, structure, cognition, and survival. A prognostic model incorporating these network features achieves an AUC of 0.90.
Hongbo Bao, Yan Bai, Jie Hu, Wencai Ding, Jiacheng Lai, Andrew Zalesky, Ye Ella Tian, Yanmei Tie, Janet Mei, Shengyu Fang, Xing Fan, Licia P. Luna, Craig K. Jones, Jianxun Ren, Weigang Cui, Jiadong Yan, Zeya Yan, Zihan Wang, Renwu Zhang, Zhonghua Lv, Yihang Jiao, Tao Jiang, Peng Liang, Haris I. Sair, Yinyan Wang   +24 more
wiley   +1 more source

Dietary Echinacea purpurea Attenuates Oxidative Stress and Alters Cytokine Gene Expression Among Heat‐Stressed Broiler Chickens at High Altitude

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Dietary Echinacea purpurea (0.75%) alleviated oxidative stress (↓NO, ↓MDA) and selectively upregulated IL‐10 and IFN‐γ expression in heat‐stressed broilers at high altitude, shifting the cytokine balance toward an anti‐inflammatory state without affecting telomere length.
Shahab Bahadoran, Shadi Vaeznia, Hossein Hassanpour   +2 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, Volume 20, Issue 10, Page 2533-2566, October 2026.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity

BioEssays, Volume 48, Issue 10, October 2026.
The dynamics of PML body formation at telomeres in cancer cells using the alternative lengthening of telomeres (ALT) pathway for telomere elongation correlate with different degrees of ALT activity and might contribute to telomere length heterogeneity in ALT cancer cells.
Huaiying Zhang
wiley   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, Volume 101, Issue 5, Page 2265-2278, October 2026.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source