Results 161 to 170 of about 80,065 (270)

Research Progress on Telomerase Activity Assays: From Traditional Methods to Novel Technologies. [PDF]

ACS Omega
He S, Zhang M, Cheng J, Xu Y, Zhong X.
europepmc   +1 more source

Preparation of Extracellular Matrices and Cell/Matrix Functional Units Produced by Cultured and Primary Fibroblasts

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract Fibroblast‐derived matrices (FDMs) provide a biologically relevant in vitro alternative to conventional two‐dimensional (2D) substrates by enabling fibroblasts to assemble and organize their own extracellular matrix (ECM) environment, closely mimicking the physiological stromal microenvironment.
Aleksandr Dolskii, Janusz Franco‐Barraza, Mariia Dmitrieva, Tiffany Luong, Olivia C. Williams, Sérgio A. Alcantara dos Santos, Yash Chhabra, Brooke A. Pereira, Michael Miano, Julia Hoopman, Lu Chen, Caneta Brown, Edna Cukierman   +12 more
wiley   +1 more source

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha, Richa Gill, Sergio Crovella, Haissam Abou‐Saleh, Sahar Isa Da'as   +4 more
wiley   +1 more source

Beyond End Protection: Shelterin, POT1 Dysfunction, and Telomere Replication Stress in Cancer. [PDF]

Biomolecules
Matsumoto T, Takaori-Kondo A.
europepmc   +1 more source

Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture conditions (static ...
Elifsu Polatlı, Burak Kahveci, Çağla Kiser, Nurhan Özlü, Gökhan Karakülah, Şermin Genç, Sinan Güven   +6 more
wiley   +1 more source

The impact of chronic exposure to cigarette and waterpipe smoke extracts on telomeres, telomerase, and cancer progression. [PDF]

Front Genet
Azar D, Kabbani D, Abdel Karim C, Akika R, Melki P, El Hourani M, Salman R, Nassar FJ, Shihadeh A, Ghantous A, Nasr R, Khoueiry-Zgheib N.   +11 more
europepmc   +1 more source

Telomerase targeting in cancer treatment:new developments

, 1999
Telomerase, a ribonucleoprotein expressed in 85% of advanced cancers but not in most somatic cells, compensates for telomeric DNA erosion and as such stabilizes cell immortality. Telomerase inhibition might restore mortality in tumor cells.
van der Zee, AGJ, de Jong, S; id_orcid, de Vries, EGE; id_orcid, de Jong, S, de Vries, EGE, Helder, MN   +5 more
core  

Identification of SORT1 as a Key Regulator of Antigen Presentation in CD16+ Monocytes During Septic Shock via Multi‐Omics and In Silico Gene Knockout Analysis

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Objective This study aimed to screen and identify hub genes correlated with septic shock through integrative analyses of bulk transcriptomics, machine learning, weighted gene co‐expression network analysis (WGCNA), single‐cell transcriptomics, and in silico gene knockout, and further dissect their underlying immunoregulatory mechanisms ...
Shulu Wu, Jiaying Zhang, Shiqi Guo, Yuting Hu, Hui Shen, Yingjie Xu, Bining Yang   +6 more
wiley   +1 more source

Alternative lengthening of telomeres is dependent on RAD52 and RAD51 gene function in the budding yeast Naumovozyma castellii. [PDF]

G3 (Bethesda)
Itriago H, Cohn M.
europepmc   +1 more source

Antibodi Telomerase Hasil Induksi Telomerase Mouse Peptide Pada Kelinci Mampu Mengikat Telomerase Pada Kultur Sel Kanker Leher Rahim

, 2014
Sel kanker leher rahim dan sel kanker lainnya bersifat immortal karena adanya protein telomerase yang berperan dalam memperpanjang telomer dengan cara melindungi proses pemendekan telomer yang terjadi setiap pembelahan normal.
Restantin, RirisLinda
core