Results 181 to 190 of about 80,065 (270)

To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy

European Journal of Haematology, Volume 117, Issue 4, Page 750-766, October 2026.
ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino, Santino Caserta, Ernesto Vigna, Giovanna Cutrona, Antonella Bruzzese, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Nicola Amodio, Franco Fais, Antonino Neri, Manlio Ferrarini, Valter Gattei, Fortunato Morabito, Massimo Gentile   +16 more
wiley   +1 more source

Virotherapy for Spinal and Spinal Cord Tumors: Current Evidence and Future Perspectives. [PDF]

Microorganisms
Uotani K, Fujiwara T, Takatori R, Yamashita K, Matsumoto K, Oda Y, Shinohara K, Tazawa H, Fujiwara T, Ozaki T.   +9 more
europepmc   +1 more source

The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma

Immunology &Cell Biology, Volume 104, Issue 9, Page 881-895, October 2026.
(Left)The identification and elimination of tumour cells is enabled by the infiltration of functional innate and adaptive immune effectors into the TME, such as natural killer cells (NK cells) and cytotoxic T cells (CD8 T cells). Effective innate and adaptive immune responses facilitate immunological control of malignant outgrowth.
Sarah J. MacDonald, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Terence J. O'Brien, Rosalind L. Jeffree, Mastura Monif   +6 more
wiley   +1 more source

La1: an evolutionarily conserved player in the Arabidopsis telomerase complex. [PDF]

Plant Cell Rep
Phadke C, Mishra SK, Song J, Holtsclaw R, Gonzalez CC, Kundel I, Marcotte EM, Papoulas O, Shippen DE.   +8 more
europepmc   +1 more source

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi‐component, multi‐target, and multi‐pathway ...
Chenrong Jin, Ding Du, Xiaorui Yu, Xiaoyan Ji, Xiuyun Zhang, Anning Li, Shuang Zu, Bo Qu, Daqing Zhao, Dianpeng Wu, Meichen Liu   +10 more
wiley   +1 more source

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1744-1758, October 2026.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao, Xiaohui Zhang, Peng Lu, Qiang Wang   +3 more
wiley   +1 more source

Repurposing MK0873 as a non-covalent hTERT-Targeting compound: a proof of concept study. [PDF]

Front Aging
Ansari M, Wali A, Rasul M, Gemzell Danielsson K, Alkasalias T, Mushtaq M.   +5 more
europepmc   +1 more source

Estrous Sheep Serum‐Derived Extracellular Vesicles Deliver Proteins That Modulate Sperm Motility in Sheep

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Sperm capacitation requires signals from the female reproductive environment, although the molecular mechanisms governing this process remain poorly understood. Estrous sheep serum (ESS) is widely used in in vitro fertilization of small ruminants, contributing to mimic the female reproductive fluids.
Clara Vidal‐Garcia, Marta Neila‐Montero, Eva Díaz‐Hernández, Paula Bóveda, Carmen María Picazo‐Córdoba, Vidal Montoro, Olga García‐Álvarez, José Julián Garde, Ana Josefa Soler, María Iniesta‐Cuerda   +9 more
wiley   +1 more source

Conditional Senescence and Longevity Mechanisms in Early-Branching Metazoans: Insights from <i>Hydra</i>. [PDF]

Curr Issues Mol Biol
Russo V, Udroiu I, Cianfanelli V, D'Ezio V, Proietti R, Sgura A, Persichini T, Colasanti M.   +7 more
europepmc   +1 more source

Evaluation of <i>Vamana</i> and <i>Virechana</i> as Interventions to Decelerate the Aging Process in Healthy Adult Volunteers: Protocol for an Exploratory Single-Arm Clinical Trial. [PDF]

JMIR Res Protoc
Soman D, Nv R, Nk P.
europepmc   +1 more source