Results 181 to 190 of about 72,827 (301)

Biogenesis and Regulation of Telomerase during Development and Cancer. [PDF]

Cold Spring Harb Perspect Biol
Chen L, Batista LFZ.
europepmc   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Telomerase-Associated Genes as Prognostic Markers in High-Grade Serous Ovarian Cancer. [PDF]

Med Sci Monit
Wang X, Han S, Wang X, Guo Y.
europepmc   +1 more source

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

Telomerase-related gene EHHADH drives lung cancer progression and shapes the immunosuppressive tumor microenvironment. [PDF]

Transl Oncol
Wei W, Wang Y, Abudukeremu D, Luo J, Du M.   +4 more
europepmc   +1 more source

Preoperative Co‐Mutation of BRAFV600E and TERT Promoter Predicts Tumor Aggressiveness and Recurrence‐Free Survival in Papillary Thyroid Carcinoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background The individual prognostic impacts of BRAFV600E and TERT promoter mutations in papillary thyroid carcinoma (PTC) are established, but the clinical significance of their co‐occurrence, especially when assessed preoperatively, requires further elucidation.
Chang Deng, Yijia Cao, Yuping Deng, Lin Chun, Su Xinliang   +4 more
wiley   +1 more source

Tumor habitat analysis using multiparametric MRI as a noninvasive correlate of longitudinal changes in telomerase activity in recurrent IDH-wildtype glioblastoma. [PDF]

Sci Rep
Jeong SY, Lee J, Choi Y, Choi M, Yu HJ, Kim HJ, Pae C, Choi SH, Park SH, Park CK, Choi KS.   +10 more
europepmc   +1 more source

Early‐Onset Mucocutaneous Findings and Isolated Progressive Thrombocytopenia in a Child With a DKC1 A353V Variant

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Dyskeratosis congenita (DC) is a rare telomere biology disorder characterized by mucocutaneous abnormalities and progressive bone marrow failure. We report a 10‐year‐old boy with a hemizygous DKC1 c.1058C > T (p.Ala353Val) variant who presented with unusually early mucocutaneous findings, including oral leukoplakia at 2 years of age, followed ...
Harun Kasapoğlu, Aslı Turgutoğlu Yılmaz, Berkin Berk Akbeyaz, Neslihan Çalışkan, Yılmaz Ay   +4 more
wiley   +1 more source

Cryo-electron microscopy structure of the budding yeast telomerase holoenzyme. [PDF]

Science
Hu H, Neumann H, Teplitz GM, Franco-Echevarría E, Chartrand P, Wellinger RJ, Nguyen THD.   +6 more
europepmc   +1 more source

MicroRNA‐Triggered Intracellular Self‐Assembly of Fluorescent Probes for Cancer Diagnosis and Therapy

ChemPhotoChem, Volume 10, Issue 6, June 2026.
We describe a self‐assembling DNA probe that integrates fluorescent miR‐21 sensing with innate immune activation. The enzyme‐free hybridization chain reaction generates long double‐stranded DNA that separates quenched TO dyes for a bright signal and acts as a cyclic GMP–AMP synthase agonist to activate stimulator of interferon gene, thereby inducing ...
Yunsong Xu, Kunihiko Morihiro, Rui Cong, Shuichiro Koga, Chae‐Eun Kim, Chan‐Gi Pack, Akimitsu Okamoto   +6 more
wiley   +1 more source