Results 191 to 200 of about 57,792 (238)
A novel polymorphism in the TERT gene is associated with lower survival in male patients with melanoma. [PDF]
Mol MedRocca MS +7 more
europepmc +1 more source
Shelterin Component TPP1 Drives Tumor Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma. [PDF]
BiomedicinesJang JE +9 more
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Der Hautarzt, 1997
Telomerase is an enzyme that elongates telomeric repeats, the specialized structures at the ends of chromosomes that provide genomic stability and compensate for the physiologic process of telomere shortening. It has been implicated in cellular senescence, immortalization, and carcinogenesis.
J, Lübbe, H, Nakazawa, G, Burg
openaire +2 more sources
Telomerase is an enzyme that elongates telomeric repeats, the specialized structures at the ends of chromosomes that provide genomic stability and compensate for the physiologic process of telomere shortening. It has been implicated in cellular senescence, immortalization, and carcinogenesis.
J, Lübbe, H, Nakazawa, G, Burg
openaire +2 more sources
Current Opinion in Structural Biology, 1999
Telomerases are RNA-dependent polymerases that catalyse the synthesis of the telomeric DNA at the tips of eukaryotic chromosomes. The recent identification of the catalytic subunit of telomerases from several different species suggests that the core of the telomerase is conserved.
M, O'Reilly, S A, Teichmann, D, Rhodes
openaire +2 more sources
Telomerases are RNA-dependent polymerases that catalyse the synthesis of the telomeric DNA at the tips of eukaryotic chromosomes. The recent identification of the catalytic subunit of telomerases from several different species suggests that the core of the telomerase is conserved.
M, O'Reilly, S A, Teichmann, D, Rhodes
openaire +2 more sources
Telomerase, Telomerase Inhibition, and Cancer
Journal of Anti-Aging Medicine, 2003Telomeres, located at the ends of eukaryotic chromosomes, are synthesized by the enzyme telomerase and are responsible for maintaining chromosome length. The absence of telomerase in most somatic cells has been associated with telomere shortening and aging of these cells. In contrast, high levels of telomerase activity are observed in over 90% of human
Ali, Ahmed, Trygve O, Tollefsbol
openaire +2 more sources
Trends in Biotechnology, 2001
There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the ...
Jerry W Shay +2 more
exaly +3 more sources
There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the ...
Jerry W Shay +2 more
exaly +3 more sources
Cancer Letters, 2003
The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
openaire +2 more sources
The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
openaire +2 more sources
Rejuvenation Research, 2006
Given the constitutive expression of telomerase in the majority of human tumors, telomerase inhibition is an attractive, broad-spectrum therapeutic target for cancer treatment. Therapeutic strategies for inhibiting telomerase activity have included both targeting components of telomerase (the protein component, TERT, or the RNA component, TERC) or by ...
Aisha, Siddiqa +2 more
openaire +2 more sources
Given the constitutive expression of telomerase in the majority of human tumors, telomerase inhibition is an attractive, broad-spectrum therapeutic target for cancer treatment. Therapeutic strategies for inhibiting telomerase activity have included both targeting components of telomerase (the protein component, TERT, or the RNA component, TERC) or by ...
Aisha, Siddiqa +2 more
openaire +2 more sources
Science, 1995
The ribonucleoprotein enzyme telomerase synthesizes telomeric DNA by copying an internal RNA template sequence. The telomerase activities of the yeasts Saccharomyces castellii and Saccharomyces cerevisiae —with regular and irregular telomeric sequences, respectively—have now been identified ...
M, Cohn, E H, Blackburn
openaire +2 more sources
The ribonucleoprotein enzyme telomerase synthesizes telomeric DNA by copying an internal RNA template sequence. The telomerase activities of the yeasts Saccharomyces castellii and Saccharomyces cerevisiae —with regular and irregular telomeric sequences, respectively—have now been identified ...
M, Cohn, E H, Blackburn
openaire +2 more sources