Results 211 to 220 of about 72,827 (301)

Rapid loss of viability in acute myeloid leukemia cells upon telomerase inactivation. [PDF]

Blood Adv
Aquilanti E, Kageler L, Bozinov V, Meyerson M.   +3 more
europepmc   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

Noncanonical chromosomal-end-specific telomeric repeat arrays in naturally telomerase-negative yeasts. [PDF]

Nucleic Acids Res
Brejová B, Hodorová V, Lichancová H, Gafurov A, Bujna D, Brázdovič F, Červenák F, Petrík T, Hegedűsová E, Forgáčová Jakúbková M, Neboháčová M, Tomáška Ľ, Sipiczki M, Vinař T, Nosek J.   +14 more
europepmc   +1 more source

Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective

Med Research, Volume 2, Issue 2, Page 204-213, June 2026.
ABSTRACT Molecular diagnostics have become an important adjunct to ultrasonography and fine‐needle aspiration (FNA) for thyroid nodules, especially in Bethesda III/IV cytology where malignancy risk is uncertain. This narrative review summarizes the diagnostic and prognostic value of key genomic drivers (BRAF V600E, RAS, RET, TERT, and selected fusions)
Guohui Xiao, Min Ding, Zhixue Min, Yihan Dong, Xuanye Cao, Qiang Lu, Cong Chen, Yahui Wu, Xin Guo, Zhen Wu, Jing Xie, Dan Xu, Haizhen Chen, Rongli Xie, Jian Fei   +14 more
wiley   +1 more source

Autophagy, telomerase, and endothelial dysfunction in COVID-19-induced cardiac injury: an evidence-graded genetic and epigenetic synthesis. [PDF]

Front Cardiovasc Med
Singh H, Tripathi G, Khan AA, Verma A, Singh A.   +4 more
europepmc   +1 more source

Telomerase [PDF]

, 2020
openaire   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Association of TERT promoter mutation and MGMT methylation with MRI features and overall survival in glioblastoma, IDH-wildtype. [PDF]

Quant Imaging Med Surg
Zhong Y, Ma X, Cheng G, Yu X, Zhang J, Liu G, Lyu J, Hu J, Bian X, Zhang J, Zhou S, Lou X.   +11 more
europepmc   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Highly mutagenic copying of telomeric circles promotes ALT establishment. [PDF]

Nat Commun
Tsai MC, Wells JM, Renninger KA, Musmaker K, Pellow R, Malkov A, Comeron JM, Malkova A.   +7 more
europepmc   +1 more source